Expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in acute and chronic inflammation

Connor, E M; Eppihimer, Michael J.; Morise, Zenichi; Granger, D. Neil; Grisham, Matthew B.

doi:10.1002/jlb.65.3.349

Cited by 145 publications

(110 citation statements)

References 39 publications

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“…Studies have shown that vascular adhesion molecules are important for T cell migration into islets, and TNF-TNFR1 signaling is important for upregulating the expression of adhesion molecules (33,34). However, we did not find decreased expression of vascular adhesion molecules in TNFR1-deficient mice.…”

Section: Discussionmentioning

confidence: 99%

“…4A, 4B). TNF-TNFR1 signaling upregulates the expression of important adhesion molecules such as MAdCAM-1 and VCAM-1 (33). Previous studies have shown that blocking MAdCAM-1 and VCAM-1 in NOD mice prevents diabetes, demonstrating the importance of these adhesion molecules in T1D progression (34).…”

Section: Tnfr1 Deficiency Does Not Affect Priming Of Ag-specific T Cementioning

confidence: 97%

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TNF Receptor 1 Deficiency Increases Regulatory T Cell Function in Nonobese Diabetic Mice

Chee

Angstetra

Mariana

et al. 2011

The Journal of Immunology

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TNF has been implicated in the pathogenesis of type 1 diabetes. When administered early in life, TNF accelerates and increases diabetes in NOD mice. However, when administered late, TNF decreases diabetes incidence and delays onset. TNFR1-deficient NOD mice were fully protected from diabetes and only showed mild peri-insulitis. To further dissect how TNFR1 deficiency affects type 1 diabetes, these mice were crossed to β cell-specific, highly diabetogenic TCR transgenic I-Ag7–restricted NOD4.1 mice and Kd-restricted NOD8.3 mice. TNFR1-deficient NOD4.1 and NOD8.3 mice were protected from diabetes and had significantly less insulitis compared with wild type NOD4.1 and NOD8.3 controls. Diabetic NOD4.1 mice rejected TNFR1-deficient islet grafts as efficiently as control islets, confirming that TNFR1 signaling is not directly required for β cell destruction. Flow cytometric analysis showed a significant increase in the number of CD4+CD25+Foxp3+ T regulatory cells in TNFR1-deficient mice. TNFR1-deficient T regulatory cells were functionally better at suppressing effector cells than were wild type T regulatory cells both in vitro and in vivo. This study suggests that blocking TNF signaling may be beneficial in increasing the function of T regulatory cells and suppression of type 1 diabetes.

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Section: Discussionmentioning

confidence: 99%

Section: Tnfr1 Deficiency Does Not Affect Priming Of Ag-specific T Cementioning

confidence: 97%

TNF Receptor 1 Deficiency Increases Regulatory T Cell Function in Nonobese Diabetic Mice

Chee

Angstetra

Mariana

et al. 2011

The Journal of Immunology

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“…MAdCAM mRNA message has been detected in brain tissue 13 and pro-inflammatory cytokines can increase the expression of MAdCAM on brain-derived endothelial cells, 12 but most studies have not observed MAdCAM protein expression in the CNS. 10,11 In preclinical models, including experimental autoimmune encephalomyelitis, CNS MAdCAM expression has been observed 14 or reported to be absent 22,27,28 and the effects of blocking MAdCAM/␣ 4 ␤ 7 interactions on encephalomyelitis lesions have either been reported to be beneficial, [15][16][17] or without effect 22,23 and dependent on ␣ 4 ␤ 1 / VCAM interactions. In order, to address these contentions described in the preclinical literature and understand the potential role for MAdCAM in control and inflamed CNS tissue, we have characterized the protein expression of MAdCAM in human unaffected and MS brain tissue and compared this with that of VCAM.…”

Section: Discussionmentioning

confidence: 99%

CNS Elevation of Vascular and Not Mucosal Addressin Cell Adhesion Molecules in Patients with Multiple Sclerosis

Allavena

Andrews

et al. 2010

The American Journal of Pathology

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The mucosal addressin cell adhesion molecule (MAdCAM) and vascular cell adhesion molecule (VCAM) appear to play roles in the recruitment of leukocytes to specialized endothelium lining the gastrointestinal tract. The purpose of this study was to clarify the role of MAdCAM and VCAM in the central nervous system by comparing protein expression in patients with multiple sclerosis (MS) and control subjects by immunohistochemistry. Specific antibodies to human VCAM and MAdCAM were used to confirm expression in control and MS nervous system specimens by immunohistochemistry. VCAM immunoreactivity was detected in endothelial cells, perivascular tissue, and in some cases, leukocytes within the meninges, gray, and white matter, of both controls and MS patients. VCAM immunoreactivity was maximal in a patient with acute active plaques, but of lower intensity and reduced distribution in controls and those with chronic active or inactive MS plaques. In contrast, MAdCAM immunoreactivity could not be detected in brain tissue from unaffected or MS patients. Taken together, these data support a role of VCAM, but not MAdCAM in the development of MS. (Am J Pathol 2010,

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“…35,36 Studies have implicated endothelial cell ICAM-1 and MadCAM-1 along with leukocyte a 4 b 1 (VLA-4) and a 4 b 7 expression as primary mediators of leukocyte recruitment in colitis. [37][38][39][40] However, other reports have clearly documented increased expression of b 2 integrins, including LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18), in Crohn's disease and ulcerative colitis suggesting that these molecules may also play an important role in governing chronic inflammation of the bowel. [41][42][43][44] Few studies have directly examined the role of these molecules during experimental colitis with these reports documenting modification of trinitrobenzene sulfonic acid (TNBS) colitis with anti-CD18 or CD11b/ CD18 antibodies.…”

Section: Discussionmentioning

confidence: 99%

Regulation of dextran sodium sulfate induced colitis by leukocyte beta 2 integrins

Abdelbaqi

Chidlow

Matthews

et al. 2006

Laboratory Investigation

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Expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in acute and chronic inflammation

Cited by 145 publications

References 39 publications

TNF Receptor 1 Deficiency Increases Regulatory T Cell Function in Nonobese Diabetic Mice

TNF Receptor 1 Deficiency Increases Regulatory T Cell Function in Nonobese Diabetic Mice

CNS Elevation of Vascular and Not Mucosal Addressin Cell Adhesion Molecules in Patients with Multiple Sclerosis

Regulation of dextran sodium sulfate induced colitis by leukocyte beta 2 integrins

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