Expression of Nitrotyrosine and Oxidative Consequences in the Trabecular Meshwork of Patients with Primary Open-Angle Glaucoma

Fernández‐Durango, Raquel; Fernández-Martínez, Amalia; García‐Feijoó, Julián; Castillo, Alfredo; Casa, Jose Martinez de la; García‐Bueno, Borja; Perez‐Nievas, Beatriz Gomez; Fernández-Cruz, A; Leza, Juan C.

doi:10.1167/iovs.07-1363

Cited by 64 publications

(63 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, NO generated by NOS2 can contribute to RGC death seen in response to increased IOP: treatment of rats with chronically elevated IOP with an inhibitor of NOS2 prevented RGC loss (Neufeld et al, 1999, 2002). More clinically relevant, expression of NOS2 was increased in the TM of POAG patients and activity of NOS2 in the TM of patients with POAG was reported to be proportional to the observed visual field defects (Fernandez-Durango et al, 2008). Together, these data could be interpreted to suggest that inhibiting NOS activity may be useful for the treatment of glaucoma by protecting RGCs from stress (e.g., as associated with elevated IOP).…”

Section: No Modulates Rgc Viabilitymentioning

confidence: 99%

Regulation of intraocular pressure by soluble and membrane guanylate cyclases and their role in glaucoma

Buys

Potter

Pasquale

et al. 2014

Front. Mol. Neurosci.

View full text Add to dashboard Cite

Glaucoma is a progressive optic neuropathy characterized by visual field defects that ultimately lead to irreversible blindness (Alward, 2000; Anderson et al., 2006). By the year 2020, an estimated 80 million people will have glaucoma, 11 million of which will be bilaterally blind. Primary open-angle glaucoma (POAG) is the most common type of glaucoma. Elevated intraocular pressure (IOP) is currently the only risk factor amenable to treatment. How IOP is regulated and can be modulated remains a topic of active investigation. Available therapies, mostly geared toward lowering IOP, offer incomplete protection, and POAG often goes undetected until irreparable damage has been done, highlighting the need for novel therapeutic approaches, drug targets, and biomarkers (Heijl et al., 2002; Quigley, 2011). In this review, the role of soluble (nitric oxide (NO)-activated) and membrane-bound, natriuretic peptide (NP)-activated guanylate cyclases that generate the secondary signaling molecule cyclic guanosine monophosphate (cGMP) in the regulation of IOP and in the pathophysiology of POAG will be discussed.

show abstract

Section: No Modulates Rgc Viabilitymentioning

confidence: 99%

Regulation of intraocular pressure by soluble and membrane guanylate cyclases and their role in glaucoma

Buys

Potter

Pasquale

et al. 2014

Front. Mol. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Interestingly, the magnitude of the IOP decrease observed in such cases has sometimes been observed to be greater in patients with POAG than in patients with ocular normal-tension or in those with angle-closure glaucoma. In another study, the authors (115) hypothesized that in vivo iNOS overexpression in the chronic progress of POAG could contribute to TM cell damage, through protein nitration by reactive peroxynitrite. This process can be an important link in the chain of events leading to the oxidative damage observed in severe POAG (116,117) .…”

Section: Nitric Oxide Synthasementioning

confidence: 99%

“…This process can be an important link in the chain of events leading to the oxidative damage observed in severe POAG (116,117) . Furthermore, the increased nitrotyrosine in severe POAG may serve as a marker of oxidative stress in the progression of cell death in POAG (115) .…”

Section: Nitric Oxide Synthasementioning

confidence: 99%

Biomarkers in primary open angle glaucoma

Kokotas

Kroupis

Chiras

et al. 2012

Clinical Chemistry and Laboratory Medicine (CCLM)

View full text Add to dashboard Cite

Glaucoma, a leading cause of blindness worldwide, is currently defi ned as a disturbance of the structural or functional integrity of the optic nerve that causes characteristic atrophic changes in the optic nerve, which may lead to specifi c visual fi eld defects over time. This disturbance usually can be arrested or diminished by adequate lowering of intraocular pressure (IOP). Glaucoma can be divided roughly into two main categories, ' open angle ' and ' closed angle ' glaucoma. Open angle, chronic glaucoma tends to progress at a slower rate and patients may not notice loss of vision until the disease has progressed signifi cantly. Primary open angle glaucoma (POAG) is described distinctly as a multifactorial optic neuropathy that is chronic and progressive with a characteristic acquired loss of optic nerve fi bers. Such loss develops in the presence of open anterior chamber angles, characteristic visual fi eld abnormalities, and IOP that is too high for the healthy eye. It manifests by cupping and atrophy of the optic disc, in the absence of other known causes of glaucomatous disease. Several biological markers have been implicated with the disease. The purpose of this study was to summarize the current knowledge regarding the non-genetic molecular markers which have been predicted to have an association with POAG but have not yet been validated.

show abstract

“…Néanmoins, les mécanismes initiaux conduisant à l'apoptose trabécu-laire demeurent encore mal connus et seuls les effets du stress oxydant ont été largement étudiés [57][58][59]. Il a été ainsi observé qu'une surexpression des ROS au sein du trabéculum entraînait une perte de fonction trabéculaire associée à une élévation de la résistance à l'écoulement de l'humeur aqueuse et une hypertonie oculaire [60,61].…”

Section: La Cellule Trabéculaire : Une Cible Thérapeutique De Choix ?unclassified

Dégénérescences rétinienne et trabéculaire dans le glaucome : pathogenèse et perspectives thérapeutiques

Denoyer

Sapienza

Goazigo

et al. 2015

Journal Français d'Ophtalmologie

View full text Add to dashboard Cite

Expression of Nitrotyrosine and Oxidative Consequences in the Trabecular Meshwork of Patients with Primary Open-Angle Glaucoma

Abstract: The increased expression and activity of iNOS in the TM of patients with POAG are proportional to the visual field defect and could lead to the increased of nitrotyrosine levels which may serve as marker of oxidative stress in the progression of cell death of the TM in POAG.

Cited by 64 publications

References 40 publications

Regulation of intraocular pressure by soluble and membrane guanylate cyclases and their role in glaucoma

Regulation of intraocular pressure by soluble and membrane guanylate cyclases and their role in glaucoma

Biomarkers in primary open angle glaucoma

Dégénérescences rétinienne et trabéculaire dans le glaucome : pathogenèse et perspectives thérapeutiques

Contact Info

Product

Resources

About