Expression of p53 Breast Cancer in Kurdish Women in the West of Iran: a Reverse Correlation with Lymph Node Metastasis

Abstract

Background: In breast cancer (BC), it has been suggested that nuclear overexpression of p53 protein might be an indicator of poor prognosis. The aim of the current study was to evaluate the expression of p53 BC in Kurdish women from the West of Iran and its correlation with other clinicopathology figures. Materials and Methods: In the present retrospective study, 231 patients were investigated for estrogen receptor (ER) and progesterone receptor (PR) positivity, defined as ≥10% positive tumor cells with nuclear staining. A binary logistic regression model was selected using Akaike Information Criteria (AIC) in stepwise selection for determination of important factors. Results: ER, PR, the human epidermal growth factor receptor 2 (HER2) and p53 were positive in 58.4%, 55.4%, 59.7% and 45% of cases, respectively. Ki67 index was divided into two groups: 54.5% had Ki67<20% and 45.5% had Ki67 ≥20%. Of 214 patients, 137(64%) had lymph node metastasis and of 186 patients, 122(65.6%) had vascular invasion. Binary logistic regression analysis showed that there was inverse significant correlation between lymph node metastasis (P=0.008, OR 0.120 and 95%CI 0.025-0.574), ER status (P=0.006, OR 0.080, 95%CI 0.014-0.477) and a direct correlation between HER2 (P=005, OR 3.047, 95%CI 1.407-6.599) with the expression of p53. Conclusions: As in a number of studies, expression of p53 had a inverse correlation with lymph node metastasis and ER status and also a direct correlation with HER2 status. Also, p53-positivity is more likely in triple negative BC compared to other subtypes.

Ki67 and P53 expression in breast cancer and their correlation with clinicopathological parameters

“…Thus p53 expression was seen in 41.66% of the cases. This is comparable with the work of Madani et al, 12 Wang XZ et al, 10 Payandeh et al 13 and Kikuchi et al 11 There is a wide variation in the expression of p53 amongst different authors. These differences may be due to heterogenous group of population, different methods for assaying p53, or different cut offs to designate high or low p53 expression.…”

“…In the present study, 56.67% of the breast cancers were highly proliferative while 43.33% cases had low Ki 67 proliferative index which is similar to the studies done by Madani SH et al, 12 Wang XZ et al, 10 Payandeh et al 13 and Hassan I et al 14 Also the mean Ki LI was found to be 28 (±20.27) with a range of 2-80%. According to various literatures, the cut off for Ki-67 LI has varied from 5 to 30%.…”

Genetic and molecular biology of breast cancer among Iranian patients

“…It was shown that the TP53 16-bp INS/DEL polymorphism can be associated with risk of BC among a sub population of Iranian patients [54]. There was also significant correlations between p53 expression, lymph node involvement, age, and tumor grade in Kurdish BC patients in Western Iran [55]. The mitochondrial pathway of apoptosis process is associated with BCL-2 which is also a prognostic factor in BC for its relation with defence mechanisms against the genotoxic damages [56, 57].…”

Prognostic factors influencing prognosis in early breast cancer patients

“…Breast cancer (BC) is a heterogeneous disorder with different pathological and histological characteristics [1]. Based on the latest statistics from the International Agency for Research on Cancer (IARC), 1,677,000 women were diagnosed with BC in 2012 and 577,000 died [2].…”

“…BC can be classified into different subtypes based on the diagnosis of oestrogen receptor (OR), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) [1]. Recurrence risk in BC changes during the follow-up time [6].…”