Expression of p53 in epithelial ovarian tumors

Amanullah, Nihad Abdul Razak; Poothiode, Usha; Vilasiniamma, Letha

doi:10.4103/ijpm.ijpm_526_19

Cited by 6 publications

(3 citation statements)

References 27 publications

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“…Other similar studies have shown variable ratios (38.46%-81.25%). 13,14 The reasons for this variation were unknown. However, possible causes for this variation may be the following:…”

Section: Discussionmentioning

confidence: 99%

Study of significance of p53 expression in primary ovarian tumour

Mohapatro,

Das,

Sahoo

2023

PJMS

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The purpose of the study was to understand the molecular changes that happen in human cancer, P53 gene mutation. Here, with respect to P53 immunohistochemical staining were taken into consideration as the surrogate for the mutational analysis. This was used for the diagnosis of ovarian cancer. The main aim of the study was to evaluate the immunohistochemical frequency of the P53 and to correlate its expression with the prognosis. In the current study 107 cases associated with ovarian cancer were studied. The samples received were hysterectomy as well as unilateral and bilateral salpingo-oophorectomy specimens, which were fixed in 10% neutral buffer formalin and processed routinely. 68.7% of the patients showed P53 malignant ovarian tumours. In the benign, it was considered as negative or in the position of borderline tumour. No statistically significant correlation was shown between the age and P53 expression. There was statistically significant difference between borderline, benign and the malignant tumors. It was also assessed that there was a statistically significant difference between P53 expression and serous carcinoma in the current study. The present study concludes that P53 tumor gene was found to be mutated in more than the 50% of the human cancer and was expressed as the aberrant form of protein. The study also concludes that in borderline tumor, P53 rarely mutates and is results in poor prognosis.

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“…Other similar studies have shown variable ratios (38.46%-81.25%). 13,14 The reasons for this variation were unknown. However, possible causes for this variation may be the following:…”

Section: Discussionmentioning

confidence: 99%

Study of significance of p53 expression in primary ovarian tumour

Mohapatro,

Das,

Sahoo

2023

PJMS

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“…Hence, choosing an antibody clone which detects both wild and mutant staining is mandatory for p53 IHC. Understanding of p53 staining patterns is mandatory to use it along with a panel of other antibodies for the correct classification and further research of morphologically confusing EOT [17].…”

Section: Discussionmentioning

confidence: 99%

Expression of mRNA (Bcl-2, p53, Caspase 9, Caspase 3 and NGX 6) on Ovarium Carcinoma

Kusumanto¹,

Prajadmo²,

Astuti³

et al. 2020

AJCEM

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Ovarian Cancer (OC) is a global health crisis and one of the deadly gynecological cancers among women worldwide. According to 2008-2012 U.S. cancer statistics, 12.7 per 100,000 women were newly diagnosed with ovarian cancer. During that same time period, the death rate was 7.7 per 100,000 women (Garcia et all, 2007, Wasana Sumanasekera et al 2018. Despite advances in medical and surgical treatment, attempts at early diagnosis, and a clearer picture of the etiology of this disease, increases in long-term survival have been small (Michael G et al, 1995). Because ovarian cancer is usually found at an advanced stage, the survival rate is lower than for other types of cancer (such as breast cancer) that are easier to detect at an early stage. If ovarian cancer is found early and treated, survival rates improve to more than 90%. (Janet M et al. 2011). Data from various immuno-hystochemical researchs, in epithelial ovarian carcinoma (EOC) showed that protein expresion is able to predict the level of progessivity and respond of chemotherapy. The aim of the study is to evaluate the relationship between protein expresion of Bcl-2 mRNA, p53 mRNA, Caspase-9 mRNA, Caspase-3 mRNA and NGX6 mRNA in various prognostic factors and respond of cysplatin based chemotherapy for ephithel ovarian cancer (EOC). Result showed there were positive relationship between Bcl-2 mRNA and P53 mRNA with the hystological type, Grade and clinical stage of EOC, however there was a negative relationship with Caspase-9 mRNA, Caspase-3 mRNA dan NGX6 mRNA, especially for Caspase-9 mRNA showed signicantly lower (p=0.024). The study demonstrated a negative relationship between NGX6 mRNA, BCl-2 mRNA and P53 mRNA expresion with the respond of Chemotherapy to EOC, however there was a positive relationship between Casp9 mRNA and Casp3 mRNA. Summeries Various level and grade of Ovarian carcinoma have positive relationship with the expresion of Bcl-2 mRNA, p53 mRNA, and negative relationship with Caspase-9 mRNA, Caspase-3 mRNA and NGX6 mRNA. The study demonstrated a negative relationship between NGX6 mRNA, Bcl-2 mRNA and P53 mRNA expresion with the respond of Chemotherapy to EOC, however there was a positive relationship between Casp9 mRNA and Casp3 mRNA.

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“…Additionally, Wang et al (13) reported that 40% of tumors were HGSC. Furthermore, Amanullah et al (30) 48.3% of tumors were classified as severe.…”

Section: G Smentioning

confidence: 98%

Value of Forkhead Box A1 (FOX A1) Immunohistochemical Expression in Epithelial Ovarian Carcinoma

Mohamed¹,

Mustafa²,

Harb³

et al. 2023

The Egyptian Journal of Hospital Medicine

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Background: Ovarian cancer is with the greatest fatality rate in the gynecological malignancy, with about two-thirds of patients receiving an advanced diagnosis because of late presentation. Additionally, 90% of patients experience recurrence and eventually develop chemo resistance. Finding new prognostic indicators and treatment targets tailored to that cancer is therefore highly desirable. It was discovered that FOX A1 plays a part in the growth and development of numerous tumours, including gliomas, breast, stomach, lung, and esophageal cancers, although its function in ovarian cancer has not been fully characterised. Aim: To assess the value of FOX A1 immunohistochemical expression in epithelial ovarian cancer and its relationship with clinicopathologic features. Materials and methods: This is a retrospective cohort study that was carried out in the Pathology department, Faculty of Medicine, Zagazig University, in the period from November 2021to November 2022. All cases of epithelial ovarian cancer of different; grades, stages and histopathological subtypes with complete clinical data were included in the study. Specimens of paraffin blocks were obtained by total abdominal hysterectomy with bilateral salpingoophorectomy (TAH+BSO) with omentectomy and lymph node dissection. They were examined by two independent pathologist for evaluation grade and stage. FOX A1 immunohistochemical staining was done for all specimens. Results: There was a statistically significant association between FOX A1 expression and patients' age, menopause, patients with bilateral lesions, ruptured capsule, positive peritoneal cytology, lymph node metastasis, omental deposits pathological grade and FIGO stage.-Conclusion: FOX A1 expression was related to poor prognostic predictors in EOC.

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Expression of p53 in epithelial ovarian tumors

Cited by 6 publications

References 27 publications

Study of significance of p53 expression in primary ovarian tumour

Study of significance of p53 expression in primary ovarian tumour

Expression of mRNA (Bcl-2, p53, Caspase 9, Caspase 3 and NGX 6) on Ovarium Carcinoma

Value of Forkhead Box A1 (FOX A1) Immunohistochemical Expression in Epithelial Ovarian Carcinoma

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