Expression of Pancreatitis-Associated Protein (PAP) in Rat Spontaneous Chronic Pancreatitis

Chronic pancreatitis: Evolving paradigms

“…These act as anti-apoptotic factors in acinar cell injury. Another earlier study by Su et al [31] showed that PAP mRNA is expressed in CP tissue even before appearance of histological changes and that this may reflect an early stage of ischemic change. The expression of PAP mRNA is induced by the cytokine IL-6.…”

“…It is a mixture of extracts from nine medicinal herbs with different pharmacological actions [81][82][83][84][85][86][87] ( table 2 ). Su et al [31] have shown that in spontaneous CP in rats this compound suppresses PAP, which is likely to be through regulation of cytokines. They also demonstrated a histopathological delay in the development of CP.…”

“…The expression of PAP mRNA is induced by the cytokine IL-6. Moreover, P8 expression is also associated with cell growth promotion, thereby implicating a regenerative role [31] . Therefore the balance between the pro-apoptotic and anti-apoptotic factors appears to be important in determining acinar cell death or survival and the severity of CP.…”

Suppressive Effect of Herbal Medicine Saikokeishito on Acinar Cell Apoptosis in Rat Spontaneous Chronic Pancreatitis

“…TJ-10 contains ingredients extracted by hot water from nine kinds of medicinal herbs [19] . The components and proportion of TJ-10 extract are Bupleuri radix 5.0 g, Cinnamomi cortex 2.0 g, Ginseng radix 2.0 g, Glycyrrhizae radix 2.0 g, Paeoniae radix 2.0 g, Pinelliae tuber 4.0 g, Scutellariae radix 2.0 g, Zingiberis rhizoma 1.0 g, Zizyphi fructus 2.0 g. The daily dosage of TJ-10 is 7.5 g, containing 4.0 g of extract.…”

“…Among etiologic factors, the amelioration rate due to TJ-10 in gallstone and idiopathic CP was higher than that in alcoholic CP [18] . We have provided evidence of the effectiveness of TJ-10 that includes an anti-inflammatory effect [19] and an anti-fibrosis effect [20] in spontaneous CP in the WBN/Kob rat. However, the mechanism is poorly understood how to prevent the occurrence of acinar destruction by suppressing acinar cell apoptosis in experimental CP.…”