Suppressive Effect of Herbal Medicine Saikokeishito on Acinar Cell Apoptosis in Rat Spontaneous Chronic Pancreatitis

Induced overexpression of CD44 associated with resistance to apoptosis on DNA damage response in human head and neck squamous cell carcinoma cells

“…Chinese herbal medicine is a mixture of many herbs following the theory of traditional Chinese medicine (11,12). Among these herbs, the main drugs that contain Scutellaria root are Shosaikoto (Xiao-Chai-Hu-Tang) (13), Daisaikoto (Da-Chai-Hu-Tang) (14), Saireito (Chai-Ling-Tang) (15), Saikokeishito (Chai-Hu-Gui-Zhi-Tang) (16), and Saikokaryukotsuboreito (Chai-Hu-Jia-Long-Gu-Mu-Li-Tang) (17). The medicinal effects of these medicines improve gastrointestinal, liver and breathing responses, targets immune function, and relieves inflammation (18).…”

A new method for treating chronic pancreatitis and preventing fibrosis using bioactive calcium silicate ion solution

“…53,54 This might be the main reason why these drugs could only be used to relieve CP symptoms. Unlike most organic drugs, which only regulated a single cell pathway, 55,56 CS ion solution systematically regulated the whole microenvironment of cells. 57 Our results in this study demonstrated that CS ion solution significantly regulated both NF-κB and Wnt/β-catenin signaling pathways in PACs simultaneously, which not only inhibited apoptosis of PACs but also promoted cell proliferation, which may contribute to its therapeutic effects on CP.…”

Kampo medicines for supportive care of patients with cancer: A brief review

“…The anti-inflammatory/regenerative properties of Kampo medicines 59 have also been explored in view of the anti-fibrotic, anti-oxidant and anti-apoptotic activity of saikokeishito. 60 , 61 , 62 , 63 Ginseng supplementation could reduce the serum levels of C-reactive protein in clinical trials. 64 …”