Expression of phosphatase of regenerating liver-3 in squamous cell carcinoma of the cervix

Abstract

To investigate the significance of PRL-3 expression in progression and metastasis of squamous cell carcinoma of the cervix (SCC). PRL-3 expression was detected by immunohistochemistry in 22 normal cervical epithelia, 30 moderate-severe dysplasia (CIN II-III) and 90 SCC cases. A total of 28 patients with SCC had lymph node metastasis, and PRL-3 expression of metastatic lymph node was detected. The association between PRL-3 expression and various clinical pathological variables in 90 patients with SCC was analyzed. Expression of PRL-3 in SCC was higher than that in normal and CINII-III, as well as higher in CINII-III than in normal (P<0.05 in all instances). PRL-3 expression was significantly different between different tumor sizes, lymph-vascular space invasion status and lymph node metastasis status (P<0.05 in all instances). PRL-3 expression in lymph node metastasis was significantly higher than that in primary SCC (P=0.049). In lymph node metastasis, the frequency of staining in cytoplasm predominantly was higher than that in matched primary cancers (P=0.001). PRL-3 may be involved in carcinogenesis of cervix and lymph node metastases of SCC and serves as an unfavorable prognostic factor in patients with SCC. PRL-3 localization in plasma may be related with cancer progress and metastasis.

Upregulation of Protein Tyrosine Phosphatase Type IVA Member 3 (PTP4A3/PRL-3) is Associated with Tumor Differentiation and a Poor Prognosis in Human Hepatocellular Carcinoma

“…Similar results have been reported by Zhao et al,22 suggesting that PRL-3 expression was correlated with angiogenesis and invasion through an upregulation of matrix metalloproteinases (MMPs) or a downregulation of E-cadherin by using limited HCC cases. PRL-3 expression has also been reported in colon, breast, ovarian, and gastric cancers, where its presence seems to have an important role in the acquisition of metastatic potential 11 , 15 – 21. In our studies, the clinical significance of PTP4A3/PRL-3 expression was noted and correlated significantly with poor tumor differentiation ( P  < 0.0001) and the OS and RFS of HCC patients (Fig.…”

“…It has been reported that PRL-3 was specifically overexpressed in liver metastases derived from colorectal cancer as well as invasive breast cancer, ovarian cancer, gastric cancer, esophageal squamous cell carcinoma, and squamous cell carcinoma of the cervix 10 – 13. Furthermore, PRL-3 was demonstrated to be a useful indicator for tumor recurrence and patient outcome in several human cancers 14 – 21. In HCC, PRL-3 was found to be overexpressed, and it was closely associated with tumor invasion and angiogenesis 22.…”

Phosphatase of regenerating liver: a novel target for cancer therapy

“…Up-regulated PRL-3 has been found in gastric carcinomas and was found to be significantly correlated to lymph node metastasis (25,26,27,28,29,30,31). Ovarian (32,33), liver (34,35), oral (36), cervical (37), esophageal (38), lung cancer (39,40), multiple myeloma (9,41), acute myeloid leukemia (AML) (42,43), and nasopharyngeal cancer (44) virtually all have been shown to exhibit high levels of PRL-3 expression. As with CRC, breast cancer, and gastric cancer, PRL-3 overexpression is overwhelmingly correlated with poor prognosis and progression to metastasis in all of the aforementioned cancer types (Table 1).…”

Phosphatase of regenerating liver-3 inhibits invasiveness and proliferation in non-small cell lung cancer by regulating the epithelial-mesenchymal transition

“…A number of studies have indicated that PRL-3 is highly expressed in several types of cancer [23–25] and is expressed to a greater extent in metastatic lesions than in primary cancers [25–27]. Nevertheless, there are few conflicting studies that have described the correlation between PRL-3 expression and lung cancer progression.…”