Expression of pigment epithelium-derived factor in psoriasis, verrucae, squamous cell carcinoma and normal skin: An immunohistochemical study

Elbalshy, Abd Ellatif M; El-Refaie, Asmaa M; Akl, E.M.

doi:10.4103/ijdvl.ijdvl_396_19

Cited by 4 publications

(2 citation statements)

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“…PEDF plays a crucial role in various processes, including keratinocyte differentiation, proliferation, skin angiogenesis, and inflammation-related diseases. The observed expression pattern of PEDF may serve as a valuable marker for keratinocyte differentiation [50].…”

Section: Pedf In Other Diseasesmentioning

confidence: 96%

The Various Roles of PEDF in Cancer

Elmi,

Dass,

Dass

2024

Cancers

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Pigment epithelium-derived factor (PEDF) is a natural immunomodulator, anti-inflammatory, anti-angiogenic, anti-tumour growth and anti-metastasis factor, which can enhance tumour response to PEDF but can also conversely have pro-cancerous effects. Inflammation is a major cause of cancer, and it has been proven that PEDF has anti-inflammatory properties. PEDF’s functional activity can be investigated through measuring metastatic and metabolic biomarkers that will be discussed in this review.

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Section: Pedf In Other Diseasesmentioning

confidence: 96%

The Various Roles of PEDF in Cancer

Elmi,

Dass,

Dass

2024

Cancers

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“…This dual therapeutic application suggests a potential common pathogenesis between cervical cancer and psoriasis ( 24 , 25 ). In addition, both psoriasis and cervical squamous cell carcinoma show hyperproliferation of squamous epithelial cells and both have angiogenic mechanisms ( 26 – 29 ). Several studies have suggested that prolonged immunosuppression in individuals with psoriasis hampers immune responses, elevating their vulnerability to tumorigenesis, including CESC ( 30 – 32 ).…”

Section: Introductionmentioning

confidence: 99%

Integrated bioinformatics combined with machine learning to analyze shared biomarkers and pathways in psoriasis and cervical squamous cell carcinoma

Liu,

Yin,

Yang

et al. 2024

Front. Immunol.

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BackgroundPsoriasis extends beyond its dermatological inflammatory manifestations, encompassing systemic inflammation. Existing studies have indicated a potential risk of cervical cancer among patients with psoriasis, suggesting a potential mechanism of co-morbidity. This study aims to explore the key genes, pathways, and immune cells that may link psoriasis and cervical squamous cell carcinoma (CESC).MethodsThe cervical squamous cell carcinoma dataset (GSE63514) was downloaded from the Gene Expression Omnibus (GEO). Two psoriasis-related datasets (GSE13355 and GSE14905) were merged into one comprehensive dataset after removing batch effects. Differentially expressed genes were identified using Limma and co-expression network analysis (WGCNA), and machine learning random forest algorithm (RF) was used to screen the hub genes. We analyzed relevant gene enrichment pathways using GO and KEGG, and immune cell infiltration in psoriasis and CESC samples using CIBERSORT. The miRNA-mRNA and TFs-mRNA regulatory networks were then constructed using Cytoscape, and the biomarkers for psoriasis and CESC were determined. Potential drug targets were obtained from the cMAP database, and biomarker expression levels in hela and psoriatic cell models were quantified by RT-qPCR.ResultsIn this study, we identified 27 key genes associated with psoriasis and cervical squamous cell carcinoma. NCAPH, UHRF1, CDCA2, CENPN and MELK were identified as hub genes using the Random Forest machine learning algorithm. Chromosome mitotic region segregation, nucleotide binding and DNA methylation are the major enrichment pathways for common DEGs in the mitotic cell cycle. Then we analyzed immune cell infiltration in psoriasis and cervical squamous cell carcinoma samples using CIBERSORT. Meanwhile, we used the cMAP database to identify ten small molecule compounds that interact with the central gene as drug candidates for treatment. By analyzing miRNA-mRNA and TFs-mRNA regulatory networks, we identified three miRNAs and nine transcription factors closely associated with five key genes and validated their expression in external validation datasets and clinical samples. Finally, we examined the diagnostic effects with ROC curves, and performed experimental validation in hela and psoriatic cell models.ConclusionsWe identified five biomarkers, NCAPH, UHRF1, CDCA2, CENPN, and MELK, which may play important roles in the common pathogenesis of psoriasis and cervical squamous cell carcinoma, furthermore predict potential therapeutic agents. These findings open up new perspectives for the diagnosis and treatment of psoriasis and squamous cell carcinoma of the cervix.

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