Expression of prostate stem cell antigen is downregulated during flavonoid-induced cytotoxicity in prostate cancer cells

Zhang, Qiang; Cheng, Guangdong; Qiu, Hongbin; Wang, Yuexin; Wang, Jingtao; Xu, Hui; Zhang, Tao; Liu, Lixin; Tao, Ye; Ren, Zhongjuan

doi:10.3892/etm.2017.4638

Cited by 8 publications

(6 citation statements)

References 39 publications

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“…Quercetin decreases the viability and proliferation of MCF-7 breast cancer cells through apoptosis activation, via increasing the levels of Bcl-2-associated X protein (BAX) and caspase-3 expression and decreasing Bcl-2 expression. In addition, quercetin activates necroptosis, via increasing the levels of receptor-interacting serine/threonine-protein kinase 1 (RIPK1) and receptor-interacting serine/threonine-protein kinase 3 (RIPK3) expression [20,21]. Both luteolin and quercetin were tested in prostate cancer cells DU145, showing cell cycle arrest [21].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, quercetin activates necroptosis, via increasing the levels of receptor-interacting serine/threonine-protein kinase 1 (RIPK1) and receptor-interacting serine/threonine-protein kinase 3 (RIPK3) expression [20,21]. Both luteolin and quercetin were tested in prostate cancer cells DU145, showing cell cycle arrest [21]. Other compounds of Stevia pilosa and Stevia eupatoria include β-sitosterol and stigmasterol, which have an antiproliferative effect by activating the extracellular receptor kinase (ERK) 1/2 pathway, and apoptosis induction, decreasing Bcl-2 expression and increasing BAX expression in breast cancer cells MDA-MB-231 [22].…”

Section: Discussionmentioning

confidence: 99%

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Stevia Eupatoria and Stevia Pilosa Extracts Inhibit the Proliferation and Migration of Prostate Cancer Cells

et al. 2020

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Background and Objectives: Prostate cancer is the second most harmful disease in men worldwide and the number of cases is increasing. Therefore, new natural agents with anticancer potential should be examined and the response of existing therapeutic drugs must be enhanced. Stevia pilosa and Stevia eupatoria are two species that have been widely used in traditional medicine, but their effectiveness on cancer cells and their interaction with antineoplastic drugs have not been studied. The aim of this study was to evaluate the anticancer activity of Stevia pilosa methanolic root extract (SPME) and Stevia eupatoria methanolic root extract (SEME) and their effect, combined with enzalutamide, on prostate cancer cells. Materials and Methods: The study was conducted on a human fibroblast cell line, and on androgen-dependent (LNCaP) and androgen-independent (PC-3) prostate cancer cell lines. The cell viability was evaluated using a Trypan Blue exclusion test for 48 h, and the migration by a wound-healing assay for 24, 48, and 72 h. Results: The results indicate that SPME and SEME were not cytotoxic at concentrations less than 1000 μg/mL in the human fibroblasts. SPME and SEME significantly reduced the viability and migration of prostate cancer cells in all concentrations evaluated. The antiproliferative effect of the Stevia extracts was higher in cancer cells than in normal cells. The enzalutamide decreased the cell viability in all concentrations tested (10–50 µM). The combination of the Stevia extracts and enzalutamide produced a greater effect on the inhibition of the proliferation and migration of cancer cells than the Stevia extracts alone, but not of the enzalutamide alone. Conclusion: The results indicate that SPME and SEME have an inhibitory effect on the viability and migration of prostate cancer cells and do not interfere with the enzalutamide anticancer effect. The data suggest that Stevia extracts may be a potential source of molecules for cancer treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Stevia Eupatoria and Stevia Pilosa Extracts Inhibit the Proliferation and Migration of Prostate Cancer Cells

et al. 2020

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“…Elevated levels of prostate stem cell antigen (PSCA) has been observed in more than 80% of prostate cancer tissues and all cases of bone metastatic prostate cancer in patients. Importantly, the treatment with genistein together with other two flavonoids belonging to the class of flavones (luteolin) and flavonols (quercetin) inhibited the expression of PSCA at the mRNA and protein level in prostate cancer DU145 cells [ 100 ].…”

Section: Targeting Metastatic Cancermentioning

confidence: 99%

Flavonoids in Cancer Metastasis

Líšková

Koklesová

Samec

et al. 2020

Cancers

137

128

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Metastasis represents a serious complication in the treatment of cancer. Flavonoids are plant secondary metabolites exerting various health beneficiary effects. The effects of flavonoids against cancer are associated not only with early stages of the cancer process, but also with cancer progression and spread into distant sites. Flavonoids showed potent anti-cancer effects against various cancer models in vitro and in vivo, mediated via regulation of key signaling pathways involved in the migration and invasion of cancer cells and metastatic progression, including key regulators of epithelial-mesenchymal transition or regulatory molecules such as MMPs, uPA/uPAR, TGF-β and other contributors of the complex process of metastatic spread. Moreover, flavonoids modulated also the expression of genes associated with the progression of cancer and improved inflammatory status, a part of the complex process involved in the development of metastasis. Flavonoids also documented clear potential to improve the anti-cancer effectiveness of conventional chemotherapeutic agents. Most importantly, flavonoids represent environmentally-friendly and cost-effective substances; moreover, a wide spectrum of different flavonoids demonstrated safety and minimal side effects during long-termed administration. In addition, the bioavailability of flavonoids can be improved by their conjugation with metal ions or structural modifications by radiation. In conclusion, anti-cancer effects of flavonoids, targeting all phases of carcinogenesis including metastatic progression, should be implemented into clinical cancer research in order to strengthen their potential use in the future targeted prevention and therapy of cancer in high-risk individuals or patients with aggressive cancer disease with metastatic potential.

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“…Consequently, addition of a polar cosolvent is imperative. Probed copolar solvents include water, methanol, ethanol, and mixtures of diverse proportions of these solvents (Yoda et al acid; pyrogallol; tricaffeoylquinic acid; 3,4,5-tricaffeoylquinic acid; 1,3,5-tricaffeoylquinic acid; rutin; 3-feruloyl-5-caffeoylquinic acid; 4-caffeoyl-5-feruloylquinic acid; 3.5-dicaffeoylquinic acid (isochlorogenic acid A); 1,4-dicaffeoylquinic acid; 3,4-dicaffeoylquinic acid (isochlorogenic acid B); 1,3-dicaffeoylquinic acid; 4,5-dicaffeoylquinic acid (isochlorogenic acid C); quercetin-3-Oglycoside; galuteolin; quercetin; roseoside; 3-feruloylquinic acid; 5-feruloylquinic acid; 4-caffeoylquinic acid (cryptochlorogenic acid); 3-caffeoylquinic acid (chlorogenic acid); 4 2020) observed that LC-MS/MS analysis was not that much reliable when it comes to quantification of phenols. The reason is that the method requires many chemicals as standards since there are many polyphenolic isomers.…”

Section: Chemical Compositionmentioning

confidence: 99%

“…According to Zhang et al [4] The immune system carries out inflammatory response upon the invasion by foreign bodies. There is a production of free radicals which destroy foreign bodies.…”

Section: Health-promoting Activity Of Stevia Phenolic Compoundsmentioning

confidence: 99%

Stevia rebaudiana, a Versatile Food Ingredient: The Chemical Composition and Medicinal Properties

Mlambo

Wang

Chen

2022

Journal of Nanomaterials

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Stevia rebaudiana is a well-known sugar substitute with low calories. Recently, Stevia rebaudiana has been reported with many medicinal properties that could possibly be used in functional foods. The work presents the chemical composition of Stevia rebaudiana. The Stevia is capable of treating renal diseases, liver pathologies, diabetes, hyperglycemia, hypoglycemia, hypertension, tumors, microbial diseases, and obesity. Nonetheless, researches are still going on to understand Stevia. Therefore, the conclusion made is not everything known about Stevia. This work highlights chemical composition of Stevia rebaudiana and its medicinal properties like antioxidant, antidiabetic, anti-inflammatory, antihypoglycaemic, anticancer, renal-healing, cardiac-healing, antilipidemic, and hepatoprotective effects. The information has been discussed from a food and medical perspective. Future works may focus on the development of novel functional foods.

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Expression of prostate stem cell antigen is downregulated during flavonoid-induced cytotoxicity in prostate cancer cells

Cited by 8 publications

References 39 publications

Stevia Eupatoria and Stevia Pilosa Extracts Inhibit the Proliferation and Migration of Prostate Cancer Cells

Stevia Eupatoria and Stevia Pilosa Extracts Inhibit the Proliferation and Migration of Prostate Cancer Cells

Flavonoids in Cancer Metastasis

Stevia rebaudiana, a Versatile Food Ingredient: The Chemical Composition and Medicinal Properties

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