Expression of RNA-binding protein IMP3 (KOC) in benign urothelium and urothelial tumors

Li, Lin; Xu, Haodong; Spaulding, Betsy O.; Liu, Cheng; Simon, Rebecca; Yao, Jorge L.; Sant'Agnese, Paul A. di; Bourne, Patricia A.; Huang, Jiaoti

doi:10.1016/j.humpath.2007.12.012

Cited by 39 publications

(44 citation statements)

References 30 publications

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“…a disturbance in the cell cycle control mechanism following Dna methyl transferase i upregulation and defects in the p53 and rb pathways are accused of playing a role in the development of invasive tumors (3,6). Missense mutations found in the p53 tumor suppressor gene have been detected in approximately 50% of bladder tumors with an unfavorable prognosis (1,4).…”

Section: Discussionmentioning

confidence: 99%

“…Superficial tumors are quite benign while a high mortality rate has been reported with invasive tumors. The histopathological stage and grade are therefore the two most important factors in determining the behavior and treatment plan for bladder tumors (2,3). However, Ta ve T1 tumors can exhibit different biological behavior (4).…”

Section: Anahtar Sözcükler: Mesane üRotelyal Karsinom Imp3 Transismentioning

confidence: 99%

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Profile of gallbladder diseases diagnosed at afyon kocatepe university: a retrospective study

Mazlum¹,

Dılek²,

Yener³

et al. 2011

TJPATH

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Objective: Superficial tumors including Ta, Tis, and T1 make up 75% of urothelial carcinomas of the bladder. While the behavior of these superficial urothelial cancers is relatively benign, invasive tumors have a significant mortality rate. However, Ta and T1 tumors might display different biological behavior. There is therefore a great need for biomarkers that can accurately distinguish the behavior of urothelial carcinomas in addition to tumor grade and stage. our aim was to determine the immunohistochemical expression profile of insulin like growth factor ii mrna binding Protein 3 (iMP3) and its correlation with tumor stage and grade in benign urothelium and bladder urothelial carcinomas. Material and Method:The expression of iMP3 in 91 patients with benign urothelium (20 cases), low grade invasive (17 cases) / noninvasive (20 cases) urothelial carcinoma and high grade invasive (20 cases) / non-invasive (14 cases) urothelial carcinoma was evaluated by immunohistochemistry in this study.Results: iMP3 was not expressed in benign urothelium, low-grade non-invasive urothelial carcinoma and high grade non-invasive urothelial carcinoma. Expression of iMP3 was found in 11.76% of low-grade invasive urothelial carcinomas and 55% of high grade invasive urothelial carcinomas. Statistical analysis including χ2 tests showed that iMP3 expression of invasive urothelial carcinomas was statistically significant (p<0.000). Conclusion:The detection of iMP3 only in invasive carcinomas although some of them were low grade showed that the expression of iMP3 may be related to aggressive behavior of urothelial carcinomas.Key Words: Urinary bladder, Urothelial carcinoma, iMP3, Transitional cell carcinoma ÖZ Amaç: Ürotelyal karsinomların %75'i yüzeyel tümörler olarak Ta, Tis ve T1 şeklinde karşımıza çıkmaktadır. Yüzeyel tümörler benign davranış gösterirken, invaziv tümörlerde ise yüksek mortalite oranı bildirilmiştir. Bununla birlikte, Ta ve T1 tümörler, farklı biyolojik davranışlar sergileyebilmektedirler. Bu durum, ürotelyal karsinomların davranışının belirlenmesinde, histopatolojik evre ve dereceye ek olarak, bazı biyolojik belirteçlere ihtiyaç olduğunu göstermektedir. Bu çalışmada amacımız, benign ürotelyum ile mesanenin ürotelyal karsinomlarında insulin like growth factor ii mrna binding Protein 3 (iMP3) ekspresyon profilini belirleyerek, tümörün histopatolojik evresi ve derecesi ile ilişkisini saptamaktır. Gereç ve Yöntem:Bu çalışmada 91 hastaya ait benign ürotelyum (20 olgu), düşük dereceli invaziv (17 olgu) / non-invaziv (20 olgu) ürotelyal karsinom ve yüksek dereceli invaziv (20 olgu) / non-invaziv (14 olgu) ürotelyal karsinom tanısı almış olgular immünohistokimyasal olarak iMP3 ekspresyonu açısından değerlendirildi. Bulgular:Benign ürotelyum, düşük dereceli non-invaziv ürotelyal karsinom ve yüksek dereceli non-invaziv ürotelyal karsinom tanısı almış olgularda iMP3 ekspresyonu saptanmadı. Düşük dereceli invaziv ürotelyal karsinom olgularının %11,76'sında, yüksek dereceli invaziv ürotelyal karsinom olgularının %55'inde...

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Section: Discussionmentioning

confidence: 99%

Section: Anahtar Sözcükler: Mesane üRotelyal Karsinom Imp3 Transismentioning

confidence: 99%

Profile of gallbladder diseases diagnosed at afyon kocatepe university: a retrospective study

Mazlum¹,

Dılek²,

Yener³

et al. 2011

TJPATH

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“…10 Later, KOC was shown to be identical to IMP3 and L523S proteins. 8,11 In the present study, we investigated the correlation among expression of IMP3, clinicopathologic characteristics, and prognosis, in patients with OSCC.…”

Section: Introductionmentioning

confidence: 99%

Insulin‐like growth factor II mRNA‐binding protein 3: A novel prognostic biomarker for oral squamous cell carcinoma

Cha

Kim

et al. 2011

Head & Neck

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“…After embryogenesis and development, IMP3 expression is detectable in occasional adult tissues, including the internal root sheath of hair follicles, germinal centers of lymph nodes ( Figure 1B), patchy gastrointestinal tract and bronchiolar epithelium (Righi, Zhang et al;Mueller-Pillasch, Pohl et al 1999;Nielsen, Christiansen et al 1999;Hammer, Hansen et al 2005;Simon, Bourne et al 2007;Xu, Bourne et al 2007;Mentrikoski, Ma et al 2009). In addition to its expression in fetal development, IMP3 has been detected in numerous malignancies including germ cell carcinomas, renal cell carcinoma, small and non-small cell lung carcinomas, urothelial carcinoma, endometrial serous and cervical carcinomas, Merkel cell carcinoma, extrapulmonary small cell carcinoma, various lymphomas, thyroid carcinoma, mammary breast carcinoma, colonic, gastric and esophageal adenocarcinomas, and osteogenic sarcoma (Asioli, Erickson et al ;Findeis-Hosey, Yang et al ;Jin, Seys et al ;Righi, Zhang et al ;Wang, Fan et al 2003;Hammer, Hansen et al 2005;Jiang 2007;Li, Rock et al 2007;Simon, Bourne et al 2007;Do, Kim et al 2008;Li, Xu et al 2008;Pryor, Bourne et al 2008;Zheng, Yi et al 2008;Jeng, Wang et al 2009;King, Pasha et al 2009;Li, Yan et al 2009;Li, Huang et al 2009;Lu, Vohra et al 2009;Mentrikoski, Ma et al 2009;Pryor, Simon et al 2009;Slosar, Vohra et al 2009;Walter, Prasad et al 2009;Yuan, Wang et al 2009). Moreover, IMP3 expression has been shown to be a marker of poorer prognosis with decreased overall survival in several tumors including renal cell carcinoma, mammary breast carcinoma, non-small cell lung carcinoma, and numerous gastrointes...…”

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confidence: 99%

IMP3 and Malignant Melanoma

Mentrikoski¹,

Xu²

2011

Advances in Malignant Melanoma - Clinical and Research Perspectives

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Expression of RNA-binding protein IMP3 (KOC) in benign urothelium and urothelial tumors

Cited by 39 publications

References 30 publications

Profile of gallbladder diseases diagnosed at afyon kocatepe university: a retrospective study

Profile of gallbladder diseases diagnosed at afyon kocatepe university: a retrospective study

Insulin‐like growth factor II mRNA‐binding protein 3: A novel prognostic biomarker for oral squamous cell carcinoma

IMP3 and Malignant Melanoma

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