Expression of Semaphorin 4F in neurons and brain oligodendrocytes and the regulation of oligodendrocyte precursor migration in the optic nerve

Armendáriz, Beatriz G.; Bribián, Ana; Esther, Pérez-Martínez; Martı́nez, Albert; Castro, Fernando de; Soriano, Eduardo; Burgaya, Ferràn

doi:10.1016/j.mcn.2011.09.003

Cited by 25 publications

(16 citation statements)

References 67 publications

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“…These inhibitors are thought to be a major factor contributing to the inability of CNS axons to regenerate after an injury. In addition, Semas play a role in oligodendrocyte migration and differentiation (e.g., (137–142); reviewed in (139)). In demyelinating disease, such as MS, and after CNS injury, oligodendrocytes fail to remyelinate axons, leaving neurons dysfunctional.…”

Section: Physiological Functionsmentioning

confidence: 99%

Semaphorins and their Signaling Mechanisms

Alto

Terman

2016

Methods in Molecular Biology

295

245

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Semaphorins are extracellular signaling proteins that are essential for the development and maintenance of many organs and tissues. The more than 20-member semaphorin protein family includes secreted, transmembrane and cell surface-attached proteins with diverse structures, each characterized by a single cysteine-rich extracellular sema domain, the defining feature of the family. Early studies revealed that semaphorins function as axon guidance molecules, but it is now understood that semaphorins are key regulators of morphology and motility in many different cell types including those that make up the nervous, cardiovascular, immune, endocrine, hepatic, renal, reproductive, respiratory and musculoskeletal systems, as well as in cancer cells. Semaphorin signaling occurs predominantly through Plexin receptors and results in changes to the cytoskeletal and adhesive machinery that regulate cellular morphology. While much remains to be learned about the mechanisms underlying the effects of semaphorins, exciting work has begun to reveal how semaphorin signaling is fine-tuned through different receptor complexes and other mechanisms to achieve specific outcomes in various cellular contexts and physiological systems. These and future studies will lead to a more complete understanding of semaphorin-mediated development and to a greater understanding of how these proteins function in human disease.

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Section: Physiological Functionsmentioning

confidence: 99%

Semaphorins and their Signaling Mechanisms

Alto

Terman

2016

Methods in Molecular Biology

295

245

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“…found across glutamatergic synapses [14], where the synaptic plasticity of the neurotransmitter glutamate allows long-term potentiation(LTP) to take place.…”

Section: Protein and Function Mutationmentioning

confidence: 99%

Identifying Genes on 2p13 as Potential Genetic Factors of Parkinson’s Disease and PARK3 Locus Candidate

Cai¹

2018

IJBBB

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Parkinson's Disease(PD) is a common progressive neurodegenerative disorder caused by both genetic and environmental risk factors, at least 25 genetic loci and 20 genes have been identified in monogenic PD. In 1998, Thomas Gasser described a genetic locus on chromosomal location 2p13, called PARK3. The monogenic gene of PARK3 is still unknown. To explore the genetic cause of PD and potential candidates for the PARK3 locus, gene expressions and biological pathways were closely analyzed between 6 known PD-associated genes and the genes on 2p13. By excluding non-pathogenic variants from the current research, this study proposes 3 genes -AAK1, EXOC6B, and SEMA4F -should be extensively researched as potential genetic factors of PD and probable PARK3 locus, and more clinical data are necessary for predicting new genetic variants.

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“…Moreover, oligodendrocytes themselves express several secreted and transmembrane semaphorins Moreau-Fauvarque et al 2003;Bernard et al 2012), which might also act influence cell-cell interaction during oligodendrocyte migration. For instance, Sema4F is a transmembrane semaphorin (Encinas et al 1999) expressed by OPCs in the mouse CNS (Armendariz et al 2012). In vitro migration assays suggest that Sema4F inhibits the migration of ON OPCs, possibly in a paracrine/autocrine manner.…”

Section: Semaphorins Control the Migration Of Oligodendrocyte Precursmentioning

confidence: 99%

Semaphorins and Cell Migration in the Central Nervous System

Chédotal

2015

Semaphorins

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In the central nervous system (CNS), neuroblasts, postmitotic neurons, and glial cells migrate along stereotyped routes from their birthplace to their final destination. Two main types of neuronal migration have been distinguished: a radial one for neurons that migrate along radial glia in a direction perpendicular to the pial surface and a tangential mode for neurons which migrate along other neurons or axons, independently of radial glia (Marin O, Rubenstein JL, Annu Rev Neurosci 26: 441-483, 2003; Metin et al, J Neurosci 28(46):11746-11752, 2008). The initiation of migration, the direction followed by migrating neurons or glia, and their decision at specific choice points are influenced by molecules in the environment of the neurons and by intrinsic developmental programs. Many studies in various systems have shown that semaphorins and their receptors play an essential role in this process. Semaphorins influence the motility of neurons and oligodendrocytes and also shape the pathway they follow during their migration. Here, I review these results, focusing on the vertebrate CNS and a few model systems. Keywords Neural stem cells • Cerebellum • Granule cells • Centrosome • Oligodendrocytes • GnRH Semaphorins Control the Radial Migration of Cortical NeuronsThe six-layered mammalian neocortex contains two main types of neurons: (1) pyramidal neurons that primarily project outside the cortex and originate from the ventricular zone of the dorsal telencephalon, or pallium; and (2) interneurons, which make local connections between different layers or across layers and originate from the ganglionic eminence in the ventral telencephalon or subpallium (Rakic 2009; A. Chédotal ( )

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Expression of Semaphorin 4F in neurons and brain oligodendrocytes and the regulation of oligodendrocyte precursor migration in the optic nerve

Cited by 25 publications

References 67 publications

Semaphorins and their Signaling Mechanisms

Semaphorins and their Signaling Mechanisms

Identifying Genes on 2p13 as Potential Genetic Factors of Parkinson’s Disease and PARK3 Locus Candidate

Semaphorins and Cell Migration in the Central Nervous System

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