Expression of Syndecan 1 on Periodontium Treated with Topical Application of Aloe - Vera

Abed, Sabrin Sami; Al-Hijazi, Athraa Y.

doi:10.12816/0031129

Cited by 4 publications

(3 citation statements)

References 10 publications

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“…Phytomedicine refers to a body of therapeutic knowledge based on natural extracts of plants, animals, fungi, and minerals [1]. Reports are available describing the use of "natural" products in the treatment of gingivitis and periodontitis, promoting periodontal wound healing after traumatic injury or pathologic disease [2], the healing of oral ulcers, pulp and periapical treatment [3], and therapeutic use for oral cancer both in vitro and in vivo [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Moringa oleifera Use in Maintaining Oral Health and Its Potential Use in Regenerative Dentistry

Shafiq,

Mahdee

2023

The Scientific World Journal

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Phytomedicine refers to the use of naturally derived products to cure and mitigate human conditions. Natural products have the advantages of causing minimum side effects, being biocompatible, available, and economical, with a wide array of biological activities. Reports have described the use of natural products with antimicrobial and anti-inflammatory properties to treat oral conditions and promote wound healing. Moringa oleifera, known as the “drumstick” or “horseradish” tree, is believed to have medicinal properties regarding a range of medical conditions, though there is limited information on its use in oral medicine. This narrative review focuses on the use of Moringa extracts in the management of oral conditions, including oral infections, inflammatory conditions, the remineralization of hard tissues, oral wound healing, and tissue regeneration, drawing from both in vitro and in vivo studies which indicate that the potential of Moringa extracts in supporting dentin-pulp regeneration after caries or trauma is worthy of more careful consideration.

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Section: Introductionmentioning

confidence: 99%

Moringa oleifera Use in Maintaining Oral Health and Its Potential Use in Regenerative Dentistry

Shafiq,

Mahdee

2023

The Scientific World Journal

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“…Additionally, there is an enhancement in collagen synthesis and cross-linking, which contributes to the process of wound contraction [7]. A study done by Abed and Al-Hijazi in 2016 used Aloe vera gel in periodontal defects related to its ability to accelerate wound healing as it increases syndecan 1 expression in epithelial cells, precursor progenitor cells and in the early stage of cell proliferation of the mesenchymal cell, inflammatory cells, and cementoblast [8].…”

Section: Introductionmentioning

confidence: 99%

Wound healing effect of a one-week Aloe Vera mouthwash: a pilot study

Ali,

Akram,

Abed

et al. 2023

Braz. Dent. Sci.

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Aloe Vera, a perennial Liliaceae plant, has medical, cosmetic, and wound-healing properties. Aloe vera has antioxidant, anti-cancer, anti-diabetic, and regenerative effects. Glucommannan increases collagen synthesis and aids healing after ginivectomy treatment. Natural mouthwashes may offer gingival wound healing efficacy with reduced side-effects when compared to Chlorhexidine. Objective: the objective of this clinical study was to compare the effects on wound healing of a one-week Aloe vera mouthwash with chlorhexidine mouthwash before gingivectomy surgical therapy. Material and Methods: a total of 45 individuals experiencing inflammatory gingival enlargement were included in the study. They underwent professional mechanical plaque removal and were then randomly divided into three groups. In group I, comprising 15 patients, participants were advised to utilize 100% Aloe vera juice as a mouthwash twice daily. Group II, also consisting of 15 patients, was instructed to use Chlorhexidine (0.2%) mouthwash twice daily. The Control group, which consisted of 15 patients, was recommended to use a placebo mouth rinse in addition to mechanical plaque removal. During the second visit, which occurred one week after the initial visit, the enlarged gingival tissue was surgically removed through scalpel gingivectomy. Immunohistochemical (IHC) analysis was performed on the excised tissue to measure the levels of fibroblast growth factor-2. Results: when compared to the control group, Aloe vera showed significant differences regarding the expression of fibroblast growth factor-2(FGF-2), and highly significant differences in angiogenesis. At the same time, there were substantial differences in angiogenesis with no significant differences in the expression of FGF2 between Chlorhexidine and control groups. Conclusion: aloe vera has exhibited potential wound-healing effects as it significantly affected the IHC expression of FGF2 and angiogenesis when used as an adjunct to plaque control before gingivectomy surgical therapy.

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“…(8) A study done by Abed and Al-Hijazi in 2016 used Aloe vera gel in periodontium defect relate its ability to accelerate wound healing as it increase syndecan 1 expression in epithelial cells, precursor progenitor cells and in early stage of cell proliferation of mesenchymal cell, and in inflammatory cells, and cementoblast. (9) Glucomannan, a mannose-rich polysaccharide and gibberellin, a growth hormone, stimulate fibroblastic activity and proliferation through the interaction with growth factor receptor on the fibroblast, which in turn enhance the synthesis of collagen after topical and oral application. Following oral and topical application, aloe vera has been proven to increase the hyaluronic acid and dermatan sulfate synthesis in the granulation tissue of a healing wound.…”

Section: Introductionmentioning

confidence: 99%

Comparison between the effects of Aloe vera and chlorhexidine on clinical periodontal parameters

Abed¹,

Ali²,

Mohsin³

2019

J Bagh Coll Dent

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Background: Periodontal diseases are one of the major dental pathologies that affect human populations worldwide at high prevalence rates The term periodontal disease usually refers only to plaque related inflammatory disease of the dental supporting tissues. Mouth rinses which act as an anti-plaque agents mostly used as adjuncts to oral hygiene. Aims of the study: To Estimate and compare the effects of Aloe vera relative to chlorhexidine on the clinical periodontal parameters (plaque index, gingival index, bleeding on probing). Material and method: A total of 44 subjects with plaque-induced gingivitis, baseline of data were collected for (PLI, GI, and BOP) and underwent oral hygiene instruction, scaling and polishing, then divided into: Study group I : 15 patients instructed to use Aloe vera mouth wash (100% pure Aloe vera juice) for home application twice daily for 7 days. Study group II: 15 patients instructed to use chlorhexidine (0.2%) mouthwash twice daily for 7 days. Control group: 14 patients instructed not to use any adjunct. Results: PLI and BOP showed significant differences between 1st and 2nd visits in all groups with the larger effects were found in chlorhexidine followed by Aloe vera while the lowest change was found in control group. GI showed significant change between 1st and 2n visits in study groups (chlorhexidine and Aloe vera groups) with the larger effects was in chlorhexidine group, while there was no significant changes were found in control group. Conclusion: chlorhexidine remain the bench mark control as adjunct to periodontal therapy but Aloe vera can be used as alternative to chlorhexidine when it cannot be used.

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Expression of Syndecan 1 on Periodontium Treated with Topical Application of Aloe - Vera

Cited by 4 publications

References 10 publications

Moringa oleifera Use in Maintaining Oral Health and Its Potential Use in Regenerative Dentistry

Moringa oleifera Use in Maintaining Oral Health and Its Potential Use in Regenerative Dentistry

Wound healing effect of a one-week Aloe Vera mouthwash: a pilot study

Comparison between the effects of Aloe vera and chlorhexidine on clinical periodontal parameters

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