Expression of the chemokine receptor Cxcr4 mRNA during mouse brain development

Tissir, Fadel; Wang, Chuan-En; Goffinet, André M.

doi:10.1016/j.devbrainres.2004.01.002

Cited by 113 publications

(119 citation statements)

References 38 publications

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“…Furthermore, the ventral-to-dorsal gradients within the cortical SVZ and cortical plate, may regulate their tangential dispersion. In contrast, as has been reported in detail by others (Stumm et al, 2003(Stumm et al, , 2007Tissir et al, 2004;Daniel et al, 2005), the Cxcl12 receptor Cxcr4 is weakly expressed in the migrating interneurons entering the cortex at both E13.5 and E16.5 [supplemental The distribution pattern of Cxcl12 in the meninges and SVZ suggests that it may play a role in organizing interneurons into streams, whereas the tapering pattern of Cxcl12 in the SVZ may facilitate the lateralto-medial dispersion of interneuron. Moreover, the spatial gradient (high in meninges to low in SVZ) and the temporal gradient (low at E13.5 to high at E16.5) of Cxcl12 suggest it may play a critical role in the MZ accumulation of interneurons in that particular time window.…”

Section: Spatial and Temporal Regulation Of Cxcl12 And Cxcr4 Expressimentioning

confidence: 39%

Regional Distribution of Cortical Interneurons and Development of Inhibitory Tone Are Regulated by Cxcl12/Cxcr4 Signaling

Li¹,

Adesnik²,

Li³

et al. 2008

J. Neurosci.

180

228

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Interneurons are born in subcortical germinative zones and tangentially migrate in multiple streams above and below the developing cortex, and then, at the appropriate developmental stage, migrate radially into the cortex. The factors that control the formation of and the timing of exit from the streams remain obscure; moreover, the rationale for this complicated developmental plan is unclear. We show that a chemokine, Cxcl12, is an attractant for interneurons during the stage of stream formation and tangential migration. Furthermore, the timing of exit from the migratory streams accompanies loss of responsiveness to Cxcl12 as an attractant. Mice with mutations in Cxcr4 have disorganized migratory streams and deletion of Cxcr4 after the streams have formed precipitates premature entry into the cortical plate. In addition, constitutive deletion of Cxcr4 specifically in interneurons alters the regional distribution of interneurons within the cortex and leads to interneuron laminar positioning defects in the postnatal cortex. To examine the role of interneuron distribution on the development of cortical circuitry, we generated mice with focal defects in interneuron distribution and studied the density of postnatal inhibitory innervation in areas with too many and too few interneurons. Interestingly, alterations in IPSC frequency and amplitude in areas with excess interneurons tend toward normalization of inhibitory tone, but in areas with reduced interneuron density this system fails. Thus, the processes controlling interneuron sorting, migration, regional distribution, and laminar positioning can have significant consequences for the development of cortical circuitry and may have important implications for a range of neurodevelopmental disorders.

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Section: Spatial and Temporal Regulation Of Cxcl12 And Cxcr4 Expressimentioning

confidence: 39%

Regional Distribution of Cortical Interneurons and Development of Inhibitory Tone Are Regulated by Cxcl12/Cxcr4 Signaling

Li¹,

Adesnik²,

Li³

et al. 2008

J. Neurosci.

180

228

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“…Seen in this light the extensive role for chemokine signaling in the control of leukocyte trafficking can be thought of as an evolutionary development of this original function. Consistent with this idea, it has been demonstrated that of all chemokines and chemokine receptors, SDF-1 and CXCR4 are the most widely expressed during the development of the embryo (Knaut et al, 2005;Knaut et al, 2003;McGrath et al, 1999;Moepps et al, 2000;Rehimi et al, 2008;Tissir et al, 2004;Yusuf et al, 2005). Moreover, the expression patterns for both SDF-1 and CXCR4 are highly dynamic consistent with the possibility that they have shifting developmental roles in the formation of many different tissues.…”

Section: The Chemokine Familymentioning

confidence: 57%

CXCR4 signaling in the regulation of stem cell migration and development

Miller¹,

Banisadr²,

Bhattacharyya³

2008

Journal of Neuroimmunology

160

125

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The regulated migration of stem cells is a feature of the development of all tissues and also of a number of pathologies. In the former situation the migration of stem cells over large distances is required for the correct formation of the embryo. In addition, stem cells are deposited in niche like regions in adult tissues where they can be called upon for tissue regeneration and repair. The migration of cancer stem cells is a feature of the metastatic nature of this disease. In this article we discuss observations that have demonstrated the important role of chemokine signaling in the regulation of stem cell migration in both normal and pathological situations. It has been demonstrated that the chemokine receptor CXCR4 is expressed in numerous types of embryonic and adult stem cells and the chemokine SDF-1/CXCL12 has chemoattractant effects on these cells. Animals in which SDF-1/CXCR4 signaling has been interrupted exhibit numerous phenotypes that can be explained as resulting from inhibition of SDF-1 mediated chemoattraction of stem cells. Hence, CXCR4 signaling is a key element in understanding the functions of stem cells in normal development and in diverse pathological situations.

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“…Furthermore, it has been reported that stromal-derived factor 1 (SDF-1) is a chemoattractant for cortical interneurons that is expressed not in the cortex itself but exclusively by meningeal cells (Stumm et al, 2003). However, several groups have reported SDF-1-expressing cells in the deeper aspect of the embryonic neocortex (Tham et al, 2001;Tissir et al, 2004), and this expression was associated with invading prospective interneurons (Daniel et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…During corticogenesis, SDF-1 has been shown to be specifically expressed in the meninges above the MZ as well as in a deep domain (Tham et al, 2001;Tissir et al, 2004;Daniel et al, 2005). Stumm et al (2003) examined the effects of SDF-1 or CXCR4 knock-out on interneuron migration at a late stage of embryonic development (E18.5) and attributed the observed misrouting of CXCR4-or Reelin-expressing interneurons exclusively to the lack of chemoattraction by meningeal SDF-1.…”

Section: Sdf-1/cxcr4 Signaling In Interneuron Migrationmentioning

confidence: 99%

Molecular Interaction between Projection Neuron Precursors and Invading Interneurons via Stromal-Derived Factor 1 (CXCL12)/CXCR4 Signaling in the Cortical Subventricular Zone/Intermediate Zone

Tiveron¹,

Rossel²,

Moepps³

et al. 2006

J. Neurosci.

184

191

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Most cortical interneurons are generated in the subpallial ganglionic eminences and migrate tangentially to their final destinations in the neocortex. Within the cortex, interneurons follow mainly stereotype routes in the subventricular zone/intermediate zone (SVZ/IZ) and in the marginal zone. It has been suggested that interactions between invading interneurons and locally generated projection neurons are implicated in the temporal and spatial regulation of the invasion process. However, so far experimental evidence for such interactions is lacking.We show here that the chemokine stromal-derived factor 1 (SDF-1; CXCL12) is expressed in the main invasion route for cortical interneurons in the SVZ/IZ. Most SDF-1-positive cells are proliferating and express the homeodomain transcription factors Cux1 and Cux2. Using MASH-1 mutant mice in concert with the interneuron marker DLX, we exclude that interneurons themselves produce the chemokine in an autocrine manner. We conclude that the SDF-1-expressing cell population represents the precursors of projection neurons during their transition and amplification in the SVZ/IZ. Using mice lacking the SDF-1 receptor CXCR4 or Pax6, we demonstrate that SDF-1 expression in the cortical SVZ/IZ is essential for recognition of this pathway by interneurons. These results represent the first evidence for a molecular interaction between precursors of projection neurons and invading interneurons during corticogenesis.

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Expression of the chemokine receptor Cxcr4 mRNA during mouse brain development

Cited by 113 publications

References 38 publications

Regional Distribution of Cortical Interneurons and Development of Inhibitory Tone Are Regulated by Cxcl12/Cxcr4 Signaling

Regional Distribution of Cortical Interneurons and Development of Inhibitory Tone Are Regulated by Cxcl12/Cxcr4 Signaling

CXCR4 signaling in the regulation of stem cell migration and development

Molecular Interaction between Projection Neuron Precursors and Invading Interneurons via Stromal-Derived Factor 1 (CXCL12)/CXCR4 Signaling in the Cortical Subventricular Zone/Intermediate Zone

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