2001
DOI: 10.1159/000053694
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Expression of the Chemokine Receptor CCR3 on Human Mast Cells

Abstract: Background: The aim of this study was to investigate whether human mast cells express functional active CCR3 receptors, which are activated by CC chemokines. These ligands include the CCR3-selective chemokines eotaxin and eotaxin-2 and the more promiscuous CC chemokines, MCP-4, MCP-3, MCP-2 and RANTES. Methods: Immunohistochemical analysis was performed on skin, gut and lung specimens. Double immunostaining was performed with anti-CCR3 and antitryptase, and anti-CCR3 and antichymase antibody (Ab) by using the … Show more

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Cited by 68 publications
(49 citation statements)
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“…Tryptase-chymase mast cells are known to express CCR3 (10), and basophils can be induced to degranulate by eotaxin via IgE-independent mechanisms (12). It is therefore reasonable to speculate that eotaxin and eotaxin-2 induce mast cell degranulation via CCR3.…”
Section: Discussionmentioning
confidence: 99%
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“…Tryptase-chymase mast cells are known to express CCR3 (10), and basophils can be induced to degranulate by eotaxin via IgE-independent mechanisms (12). It is therefore reasonable to speculate that eotaxin and eotaxin-2 induce mast cell degranulation via CCR3.…”
Section: Discussionmentioning
confidence: 99%
“…Eotaxin causes the rapid accumulation of eosinophils in guinea pig lung (4) and has been identified as an important eosinophil chemoattractant in both mouse and man (5,6). Eotaxin was initially found to be selective for eosinophils (7), but has now been shown to be chemotactic for basophils (8), Th2 lymphocytes (9), and tryptase-chymase mast cells (10). Eotaxin has important physiological actions beyond chemotaxis, including the induction of eosinophil degranulation (11) and IgE-independent degranulation of basophils (12).…”
mentioning
confidence: 99%
“…Eotaxin-2 and eotaxin-3 are only distantly related to eotaxin-1 because they are only ϳ30% identical in sequence and are located on different chromosomes (19,20). The specific activity of all eotaxins is mediated by the selective expression of the eotaxin receptor, CCR3, a seven-transmembrane spanning, G protein-coupled receptor, primarily expressed on eosinophils (21,22), while noted on a subset of Th2 cells (23) and mast cells in humans (24), little is known about the expression of CCR3 on cells other than eosinophils in the mouse. Notably, the eotaxin chemokines cooperate with IL-5 in the induction of tissue eosinophilia.…”
mentioning
confidence: 99%
“…This receptor is highly expressed on eosinophils (3,8,9), and all three eotaxins have been shown to be potent eosinophil chemoattractants in vitro (2, 5-7, 10 -12). More recently, CCR3 has been detected on other cell types, including basophils, mast cells, and a subpopulation of Th2 cells (13)(14)(15). As all of these cell types are involved in allergic inflammatory reactions, it is hypothesized that the eotaxins play an important role in coordinating the recruitment of all of these cell types to sites of allergic inflammation.…”
mentioning
confidence: 99%