Expression of the estrogen receptor in blood neutrophils of dairy cows during the periparturient period

Lamote, Inge; Meyer, Evelyne; Ketelaere, Adelheid De; Duchateau, Luc; Burvenich, Christian

doi:10.1016/j.theriogenology.2005.07.017

Cited by 28 publications

(25 citation statements)

References 37 publications

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“…Since neutrophils in both the peripheral blood and tissues express functionally active ERα and ERβ2223, we studied if estrogen targets neutrophils specifically to induce the inflammatory gene signatures. Mammary neutrophils were isolated using biotin-labelled Gr-1 antibody(RB6-8C5)24.…”

Section: Resultsmentioning

confidence: 99%

Estrogen reprograms the activity of neutrophils to foster protumoral microenvironment during mammary involution

Chung

Shrestha

et al. 2017

Sci Rep

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Epidemiological studies have indicated increased risk for breast cancer within 10 years of childbirth. Acute inflammation during mammary involution has been suggested to promote this parity-associated breast cancer. We report here that estrogen exacerbates mammary inflammation during involution. Microarray analysis shows that estrogen induces an extensive proinflammatory gene signature in the involuting mammary tissue. This is associated with estrogen-induced neutrophil infiltration. Furthermore, estrogen induces the expression of protumoral cytokines/chemokines, COX-2 and tissue-remodeling enzymes in isolated mammary neutrophils and systemic neutrophil depletion abolished estrogen-induced expression of these genes in mammary tissue. More interestingly, neutrophil depletion diminished estrogen-induced growth of ERα-negative mammary tumor 4T1 in Balb/c mice. These findings highlight a novel aspect of estrogen action that reprograms the activity of neutrophils to create a pro-tumoral microenvironment during mammary involution. This effect on the microenvironment would conceivably aggravate its known neoplastic effect on mammary epithelial cells.

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Section: Resultsmentioning

confidence: 99%

Estrogen reprograms the activity of neutrophils to foster protumoral microenvironment during mammary involution

Chung

Shrestha

et al. 2017

Sci Rep

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“…This possibility is supported by the fact that reproductive steroid receptors have been described in lymphomyeloid tissues. In mammals, the estrogen receptor (Koehler et al, 2005;Lamote et al, 2006) and androgen receptor (Sar et al, 1990;Benten et al, 2002) are present in various immune tissues. Reproductive steroid receptors are also present in lymphomyeloid tissues of birds (Sullivan et al, 1988;Pasanen et al, 1998) and fish (Slater and Schreck, 1993;Patino et al, 2000), as well as elasmobranch epigonal tissue (Squalus acanthias, Leucoraja erinacea; Engel, 2008).…”

Section: Discussionmentioning

confidence: 99%

Morphological relationships and leukocyte influence on steroid production in the epigonal organ‐ovary complex of the skate, Leucoraja erinacea

Lutton

Callard

2008

Journal of Morphology

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In elasmobranchs, a unique association exists between an immune tissue, the epigonal organ (EO), and the gonads. In this study, the histological and vascular relationships of the EO and ovarian follicles of the little skate, Leucoraja erinacea, were assessed. Perfusions of Evans blue dye and Batson's monomer showed a shared vascular pathway from the gonadal artery into the epigonal-ovary complex, with blood first entering the EO and then perfusing the ovarian follicles. Histological studies demonstrated direct cellular contact between epigonal leukocytes and the follicle wall (FW), as well as the presence of leukocytes between the steroidogenic theca and granulosa cells. In vitro analyses demonstrated that epigonal cells co-cultured with FW cells cause a dose-dependent inhibition of estrogen (E2) and testosterone (T) production. In contrast, conditioned media from epigonal leukocytes, stimulated or unstimulated with lipopolysaccharide (10 microg/ml), increase the production of E2 and T from FW cells of the ovaries. These studies provide a basis for further investigations of leukocyte secreted factors and cell contact modulation of follicular steroid production.

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“…It has been hypothesized that 17 β ‐oestradiol may contribute to the induction of a compromised PMN function around parturition (Burvenich et al., 2007). Recently, we detected oestrogen receptors on bovine blood PMN at both protein and mRNA level (Lamote et al., 2006, 2007). Glucocorticoids prevent PMN margination by reducing the expression of L‐selectin and CD18 on PMN (Burton et al., 1995).…”

Section: Does Dry Period Length Affect Mammary Defence?mentioning

confidence: 99%

REVIEW ARTICLE: An integrated view on how the management of the dry period length of lactating cows could affect mammary biology and defence

Pezeshki

Capuco

Spiegeleer

et al. 2010

Journal of Animal Physiology and Animal Nutrition

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Summary The dry period is necessary to facilitate cell turnover in the bovine mammary gland and to optimize milk production in the next lactation. An 8‐week dry period has long been the golden standard of management for dairy cows. Genetic improvements and new management technologies have led to higher milk production and a need for re‐evaluation of the dry period length. Over the last decade, dry period length has been proposed to be shortened or eliminated mainly from an economic point of view. However, the influence of modified dry period length on the immune defence of the bovine mammary gland and the occurrence of new intramammary infections has not yet been appreciated. The objective of this review is to discuss the bovine mammary gland biology, defence and systemic health when the dry period length is modified. Shortening or eliminating the dry period may minimize or remove the impact of milk accumulation at dry off, thereby lessening the immunodeficiency of the dam that is characteristic of this period. Composition of mammary secretions may change and the extent of tissue remodelling may be reduced when the dry period is reduced or eliminated. Additionally, impact of the dry period length on energy and nutritional status, and on hormonal and local regulatory factors, lead us to hypothesize that changing the dry period length might also affect the response to intramammary infection. It is concluded that there is a need to integrate mammary gland biology and defence mechanisms in studies dealing with modified dry period lengths.

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Expression of the estrogen receptor in blood neutrophils of dairy cows during the periparturient period

Cited by 28 publications

References 37 publications

Estrogen reprograms the activity of neutrophils to foster protumoral microenvironment during mammary involution

Estrogen reprograms the activity of neutrophils to foster protumoral microenvironment during mammary involution

Morphological relationships and leukocyte influence on steroid production in the epigonal organ‐ovary complex of the skate, Leucoraja erinacea

REVIEW ARTICLE: An integrated view on how the management of the dry period length of lactating cows could affect mammary biology and defence

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