Expression of Tie‐1 and 2 receptors, and angiopoietin‐1, 2 and 4 in gastric carcinoma; immunohistochemical analyses and correlation with clinicopathological factors

Nakayama, Toshiyuki; Yoshizaki, Ayumi; Kawahara, Nobuaki; Ohtsuru, Akira; Wen, Chun-Yang; Fukuda, Eiichiro; Nakashima, Masahiro; Sekine, Ichiro

doi:10.1111/j.0309-0167.2004.01817.x

Cited by 34 publications

(19 citation statements)

References 26 publications

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“…In contrast, overexpression of ANG-2 in hepatomas, gliomas, and colorectal and gastric carcinomas was found to enhance angiogenesis and augment tumor malignancy (46,(53)(54)(55)(56). Furthermore, strong correlation of ANG-2 with ANG-1 in neuroblastoma (57), gliomas (14,35), breast and prostate carcinomas (58), hepatocellular carcinoma (59), non -small cell lung carcinomas (60,61), and gastric adenocarcinoma (62) has been associated with aggressive tumor growth.…”

Section: Ang-2mentioning

confidence: 99%

Angiopoietin: A TIE(d) Balance in Tumor Angiogenesis

Shim

Wong

2007

Molecular Cancer Research

152

111

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Angiopoietins (ANG-1 and ANG-2) and their TIE-2 receptor tyrosine kinase have wide-ranging effects on tumor malignancy that includes angiogenesis, inflammation, and vascular extravasation. These multifaceted pathways present a valuable opportunity in developing novel inhibition strategies for cancer treatment. However, the regulatory role of ANG-1 and ANG-2 in tumor angiogenesis remains controversial. There is a complex interplay between complementary yet conflicting roles of both the ANGs in shaping the outcome of angiogenesis. Embryonic vascular development suggests that ANG-1 is crucial in engaging interaction between endothelial and perivascular cells. However, recruitment of perivascular cells by ANG-1 has recently been implicated in its antiangiogenic effect on tumor growth. It is becoming clear that TIE-2 signaling may function in a paracrine and autocrine manner directly on tumor cells because the receptor has been increasingly found in tumor cells. In addition, A 5 B 1 and A v B 5 integrins were recently recognized as functional receptors for ANG-1 and ANG-2. Therefore, both the ligands may have wide-ranging functions in cellular activities that affect overall tumor development. Collectively, these TIE-2 -dependent and TIE-2 -independent activities may account for the conflicting findings of ANG-1 and ANG-2 in tumor angiogenesis. These uncertainties have impeded development of a clear strategy to target this important angiogenic pathway. A better understanding of the molecular basis of ANG-1 and ANG-2 activity in the pathophysiologic regulation of angiogenesis may set the stage for novel therapy targeting this pathway. (Mol Cancer Res 2007;5(7):655 -65)

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Section: Ang-2mentioning

confidence: 99%

Angiopoietin: A TIE(d) Balance in Tumor Angiogenesis

Shim

Wong

2007

Molecular Cancer Research

152

111

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“…A receptor-mediated response is likely given that Tie2 expression was induced by hyperoxia 59 and Tie2 has been detected on normal and transformed epithelial cells. [66][67][68] Furthermore, we detected Tie2 mRNA in the MLE cells used for our in vitro studies. 59 Importantly, we found Ang2-mediated hyperoxia-induced increases in initiator and effector caspases, namely caspase-3, -8 and -9.…”

Section: Angiopoietin 2 and Hali In Animal Modelsmentioning

confidence: 99%

The Role of Angiopoietin 2 in Hyperoxia-Inuduced Acute Lung Injury

Bhandari¹,

Elias²

2007

Cell Cycle

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“…StrongevidencefortheinvolvementoftheIAPfamilyin theregulationoftumorprogression,cellulargrowth,anddifferentiation has been found [10][11][12]. Previous studies have shown that survivin or livin expression is associated with tumorigenesis and metastasis in epithelial tumors including CRC.…”

Section: Introductionmentioning

confidence: 99%

Significant Elevation of Survivin and Livin Expression in Human Colorectal Cancer: Inverse Correlation between Expression and Overall Survival

2011

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Background: Survivin and livin are novel members of the inhibitor of apoptosis protein family, which have rarely been studied in human colorectal cancer (CRC). This study aims to examine their expression and association with clinicopathological factors and prognosis in CRC, and evaluate the possibility of their use as biomarkers for CRC. Patients and Methods: We investigated the expression of survivin and livin in 61 CRC samples using immunohistochemical staining (Envision) and correlated it with the survival of these patients using log-rank test and correlation analysis. Results: Among the 61 cases, 60.7 and 54.1% were positive for expression of survivin (p < 0.05) and livin (p < 0.05). No expression of survivin and livin was detected in normal colorectal mucosa. An inverse correlation (r = –0.9916) between the increased survivin and livin levels and overall survival was observed in univariate survival analysis. The expression of both proteins was not correlated with age, gender, degrees of differentiation, and TNM stage (p < 0.05) in malignancies. Conclusions: High expression of both survivin and livin may influence the prognosis of CRC. This finding opens new perspectives for CRC prognosis because survivin and livin can both be used as biomarkers or potential therapeutic targets.

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Expression of Tie‐1 and 2 receptors, and angiopoietin‐1, 2 and 4 in gastric carcinoma; immunohistochemical analyses and correlation with clinicopathological factors

Abstract: Ties and Angs were highly expressed in human gastric adenocarcinoma cells. These findings suggest that the Tie-Ang receptor-ligand complex is one of the factors involved in the cellular differentiation and progression of human gastric adenocarcinoma.

Cited by 34 publications

References 26 publications

Angiopoietin: A TIE(d) Balance in Tumor Angiogenesis

Angiopoietin: A TIE(d) Balance in Tumor Angiogenesis

The Role of Angiopoietin 2 in Hyperoxia-Inuduced Acute Lung Injury

Significant Elevation of Survivin and Livin Expression in Human Colorectal Cancer: Inverse Correlation between Expression and Overall Survival

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