EXPRESSION OF VARIOUS ANTIGENS BY DIFFERENT COMPONENTS OF UTERINE MIXED MÜLLERIAN TUMORS: An Immunohistochemical Study

Chung, Ming-Teng; Mukai, Kiyoshi; Teshima, Shin‐ichi; Kishi, Kiyozo; Shimosato, Yukío

doi:10.1111/j.1440-1827.1988.tb01070.x

Cited by 7 publications

(8 citation statements)

References 16 publications

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“…However, the wealth of evidence points to the fact that these neoplasms are distinct from sarcomas of the uterus and should be considered separately as mixed epithelial and stromal tumors. [23][24][25][26][27][28][29] Our cytologic classification should reflect this newer histologic classification, particularly in view of the distinct cytologic differences from other primary mesenchymal tumors of the uterus. 30332 None of the series on cervicovaginal cytology of CS 30-37 present the data in the context of current Bethesda System for reporting cervical/vaginal cytologic diagnoses.…”

Section: Discussionmentioning

confidence: 99%

Cervicovaginal cytology in carcinosarcoma [malignant mixed mullerian (mesodermal) tumor] of the uterus

Costa

Tidd

Willis

1992

Diagnostic Cytopathology

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We examined the cervicovaginal cytology (PAP) findings in a series of 21 endometrial and 2 cervical carcinosarcomas (CS) [malignant mixed mullerian (mesodermal) tumors] (MMMT). Initial cytology diagnosis was positive for cancer in 14 of 23 cases (sensitivity of 61%); however, CS was correctly identified only 2 times. The remaining 12 cancer diagnoses were carcinomas: 10 adenocarcinomas (4 endometrial, 1 cervical, and 5 adenocarcinomas not otherwise specified), 1 squamous carcinoma, and 1 poorly differentiated carcinoma. Seventeen smears were available for review, all 8 false negative, one unsatisfactory, and 8 of 14 true positive smears. One false negative smear showed rare clusters diagnostic of adenocarcinoma. The remaining 7 false negative smears showed 3 high grade squamous dysplasias (two with additional findings: one showed atypical spindle cells and the other showed endometrial stromal cells), 2 extensive repair changes, and 2 negatives. The unsatisfactory smear showed atypical spindle cells. Review of the 8 true positive smears confirmed malignant spindle cells in the two cases originally identified as CS by cytology and in 3 other cases originally identified as adenocarcinoma. Of 9 smears positive for cancer available for review, 4 showed only carcinoma cells. PAP positive for cancer was associated with high stage at presentation (P less than .025) and recurrent disease (P less than .001) (even among stage I or II patients, P less than .025). PAP positive for cancer showed no association with depth of myometrial invasion, size, grade, or histologic type of carcinosarcoma. The results of this study demonstrate the importance of consultative cytology reporting in which recommendations for appropriate biopsy are included in the report.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 99%

Cervicovaginal cytology in carcinosarcoma [malignant mixed mullerian (mesodermal) tumor] of the uterus

Costa

Tidd

Willis

1992

Diagnostic Cytopathology

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“…In the last few years, evidence in favor of a monoclonal origin particularly supporting the conversion hypothesis has accumulated, based on a number of studies using sensitive morphological, cytogenetic, ultrastructural, and immunohistochemical techniques [2,4,6,8,13,16,29,30].…”

Section: Introductionmentioning

confidence: 99%

Molecular genetic aberrations of ovarian and uterine carcinosarcomas—a CGH and FISH study

Schipf¹,

Mayr

Kirchner

et al. 2008

Virchows Arch

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The origin of carcinosarcomas of the ovary and uterus has long been discussed. In this study, we used a molecular-genetic approach to elucidate the tumorigenesis of carcinosarcomas of these organs correlating our findings with the specific biphasic pattern of these tumors. We analyzed a series of 30 paraffin-embedded carcinosarcomas of the ovary and the uterus using comparative genomic hybridization (CGH) and fluorescence in-situ hybridization (FISH). In general, gains (85%) were observed more frequently, than losses (30%). Characteristic and frequent chromosomal amplification was observed on chromosome 8q and 20q (42 and 70%). FISH revealed c-myc (8q24.12) and ZNF217 (20q13.2) amplification in 78 and 87%. Amplification of ZNF217 was mostly seen in both tumor components, whereas amplification of c-myc was observed less often in the sarcomatous than in the carcinomatous tumor component. Analysis of the proliferation index using Ki67 immunohistochemistry revealed a strong or moderate expression in all cases, wherein the carcinomatous tumor component showed significantly a higher proliferation index compared to the sarcomatous tumor areas. Although our results are in agreement with a monoclonal origin of ovarian and uterine carcinosarcomas, the carcinomatous component seems to be the more aggressive part of the tumor. Furthermore, the observed patterns of genetic aberrations are highly similar to those of serous carcinomas. This is compatible with the current opinion that these neoplasms should be considered as metaplastic carcinomas.

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“…Previous efforts to discern the cell, or cells, of origin of carcinosarcoma focused upon the phenotype of the component cells ( 1 –3 ) . Demonstration of mesenchymal or epithelial differentiation by light microscopic, immunohistochemical, and ultrastructural studies was interpreted as evidence of origin from these tissues.…”

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confidence: 99%

Co-expression of p53 by epithelial and stromal elements in carcinosarcoma of the female genital tract: an immunohistochemical study of 19 cases

Szukala¹,

Маркс²,

Burchette³

et al. 1999

Int J Gynecol Cancer

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Carcinosarcoma is an aggressive neoplasm of the female genital tract, which comprises 1-2% of malignancies of the uterine corpus. Because of the broad range of differentiation exhibited by these tumors, the precise nature of the relationship between epithelial and stromal components in this unique tumor remain unclear. Previous studies have demonstrated that mutation and consequent overexpression of the tumor suppressor gene p53 occurs frequently in carcinosarcoma and is conserved from primary to metastastic sites. We examined p53 accumulation in formalin-fixed, paraffin-embedded archival sections in 19 cases previously shown to have mutations in the p53 gene and performed semi-quantitative analysis of the intensity of staining and relative density of positive cells and stromal and glandular elements. There was a high level of concordance of immunohistochemical staining for the p53 oncoprotein between glandular and stromal elements. These results further suggest a clonal origin for the diverse elements of carcinosarcoma.

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EXPRESSION OF VARIOUS ANTIGENS BY DIFFERENT COMPONENTS OF UTERINE MIXED MÜLLERIAN TUMORS: An Immunohistochemical Study

Cited by 7 publications

References 16 publications

Cervicovaginal cytology in carcinosarcoma [malignant mixed mullerian (mesodermal) tumor] of the uterus

Cervicovaginal cytology in carcinosarcoma [malignant mixed mullerian (mesodermal) tumor] of the uterus

Molecular genetic aberrations of ovarian and uterine carcinosarcomas—a CGH and FISH study

Co-expression of p53 by epithelial and stromal elements in carcinosarcoma of the female genital tract: an immunohistochemical study of 19 cases

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