Expression of various types of alternatively spliced WAPL transcripts in human cervical epithelia

Oikawa, Kosuke; Akiyoshi, Ayumi; Tanaka, Masami; Takanashi, Masakatsu; Nishi, Hirotaka; Isaka, Keiichi; Kiseki, Hisami; Idei, Tomoko; Tsukahara, Yutaka; Hashimura, Naohiko; Mukai, Kiyoshi; Kuroda, Masahiko

doi:10.1016/j.gene.2008.07.001

Cited by 11 publications

(8 citation statements)

References 18 publications

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“…Increasing evidence has revealed a link between malfunctioning of the cohesin network with different forms of human cancers. Overexpression of WAPL, a cohesin‐binding protein that facilitates timely release of cohesin from chromosome arms during prophase, has been observed in cervical cancers, and down‐regulation of WAPL inhibits the growth of tumors derived from cervical cancer cell lines [132,133]. Separase, the molecular scissor that cleaves cohesin during the metaphase to anaphase transition [reviewed in 2], has also been implicated in tumorigenesis.…”

Section: Impairment Of the Cohesin Network Leads To Development Of Comentioning

confidence: 99%

Cohesin: Functions beyond sister chromatid cohesion

Mehta¹,

Kumar²,

Srivastava³

et al. 2013

FEBS Letters

111

101

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a b s t r a c tFaithful segregation of chromosomes during mitosis and meiosis is the cornerstone process of life. Cohesin, a multi-protein complex conserved from yeast to human, plays a crucial role in this process by keeping the sister chromatids together from S-phase to anaphase onset during mitosis and meiosis. Technological advancements have discovered myriad functions of cohesin beyond its role in sister chromatid cohesion (SCC), such as transcription regulation, DNA repair, chromosome condensation, homolog pairing, monoorientation of sister kinetochore, etc. Here, we have focused on such functions of cohesin that are either independent of or dependent on its canonical role of sister chromatid cohesion. At the end, human diseases associated with malfunctioning of cohesin, albeit with mostly unperturbed sister chromatid cohesion, have been discussed.

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Section: Impairment Of the Cohesin Network Leads To Development Of Comentioning

confidence: 99%

Cohesin: Functions beyond sister chromatid cohesion

Mehta¹,

Kumar²,

Srivastava³

et al. 2013

FEBS Letters

111

101

View full text Add to dashboard Cite

show abstract

“…Some scholars have detected the expression levels of mRNA of the hWAPL in cervical cancer, ovarian cancer, breast cancer, lung cancer, renal carcinoma, colon cancer and their corresponding normal tissues and found that the mRNA expression of the hWAPL gene in cervical cancer increased significantly compared with that in other cancerous tissues and their corresponding normal tissues [20][21]. Researches also have found that expression of hWAPL in cervical cancer cells with positive and negative HPV was high but expression of hWAPL in the normal cervical tissue was lower [22]. Hence, hWAPL expression may be more closely related to cervical cancer compared with HPV infection [23].…”

Section: Discussionmentioning

confidence: 99%

Expression of Fhit, hWAPL and Survivin in Cervical Squamous Cell Carcinoma and Significance Thereof

Li¹,

Zhang²,

Li³

2020

SJPH

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“…RNA isolation and first-strand cDNA synthesis were performed as previously described (Oikawa et al , 2008a). For detection of TLS–CHOP variants, we performed PCR analysis with TLS–CHOP detection primers 5′-CTTATGGCCAGAGCCAGAAC-3′ and 5′-AAGGCAATGACTCAGCTGCC-3′.…”

Section: Methodsmentioning

confidence: 99%

A novel oncogenic pathway by TLS–CHOP involving repression of MDA-7/IL-24 expression

et al. 2012

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Background:Translocated in liposarcoma-CCAAT/enhancer binding protein homologous protein (TLS–CHOP) (also known as FUS-DDIT3) chimeric oncoprotein is found in the majority of human myxoid liposarcoma (MLS), but its molecular function remains unclear.Methods:We knockdowned TLS–CHOP expression in MLS-derived cell lines by a specific small interfering RNA, and analysed the gene expression profiles with microarray.Results:TLS-CHOP knockdown inhibited growth of MLS cells, and induced an anticancer cytokine, melanoma differentiation-associated gene 7 (MDA-7)/interleukin-24 (IL-24) expression. However, double knockdown of TLS–CHOP and MDA-7/IL-24 did not inhibit MLS cell growth.Conclusion:Repression of MDA-7/IL-24 expression by TLS–CHOP is required for MLS tumour growth, and TLS–CHOP may become a promising therapeutic target for MLS treatment.

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Expression of various types of alternatively spliced WAPL transcripts in human cervical epithelia

Cited by 11 publications

References 18 publications

Cohesin: Functions beyond sister chromatid cohesion

Cohesin: Functions beyond sister chromatid cohesion

Expression of Fhit, hWAPL and Survivin in Cervical Squamous Cell Carcinoma and Significance Thereof

A novel oncogenic pathway by TLS–CHOP involving repression of MDA-7/IL-24 expression

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