2000
DOI: 10.1354/vp.37-2-129
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Expression of Viral Proteins in Feline Leukemia Virus-associated Enteritis

Abstract: Abstract. Fourteen cases of feline leukemia virus (FeLV)-associated enteritis were immunohistologically examined for the expression of FeLV proteins gp70, p27, and p15E in the jejunum, mesenteric lymph nodes, spleen, and bone marrow. Results were compared with those of FeLV-infected cats without intestinal alterations. Other viral infections and specific bacterial, fungal, and parasitic infections were excluded by standard microbiologic methods, histopathology, immunohistology, and in situ hybridization. In Fe… Show more

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Cited by 22 publications
(33 citation statements)
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“…Immunohistochemistry to detect parvovirus antigen was performed using a monoclonal mouse anti-CPV1-2A1 antibody (Custom Monoclonal Antibodies International, Sacramento, CA) according to the method of Kipar et al (33). Briefly, after incubation with the primary antibody, a biotin-conjugated goat anti-mouse antibody (Vector Laboratories, Inc., Burlingame, CA) was applied.…”
Section: Methodsmentioning
confidence: 99%
“…Immunohistochemistry to detect parvovirus antigen was performed using a monoclonal mouse anti-CPV1-2A1 antibody (Custom Monoclonal Antibodies International, Sacramento, CA) according to the method of Kipar et al (33). Briefly, after incubation with the primary antibody, a biotin-conjugated goat anti-mouse antibody (Vector Laboratories, Inc., Burlingame, CA) was applied.…”
Section: Methodsmentioning
confidence: 99%
“…It appears that this syndrome might actually not be caused by FeLV itself, as previously thought, but by co-infection with FPV. The syndrome also has been referred to as FAE in cats with progressive FeLV infection because the clinical signs observed are usually gastrointestinal, including hemorrhagic diarrhea, vomiting, oral ulceration or gingivitis, anorexia, and weight loss [78,79]. It is still unclear whether all theses syndromes have the same origin and are simply caused by co-infection with FPV (and even modified life FPV vaccines have been discussed) or if they are caused by FeLV itself [77].…”
Section: Clinical Signsmentioning
confidence: 99%
“…30 Thus, p27 capsid protein cell positivity indicates that viral infection has occurred at a certain point but does not imply productive and pathogenic viral assembly and, hence, does not indicate infection or disease in progress. 30,66 Kipar et al 40 document a correlation between gp70 intensity and the presence and severity of intestinal lesions, supporting the main pathogenic role of envelope proteins. Thus, FeLV gp70 envelope protein expression denotes viral assembly, confirming viral replication and productive infection.…”
Section: Discussionmentioning
confidence: 93%
“…Similar results have been previously reported. 33,40,62 FeLVpositive cats developing FeLV enteritis with gp70 strong expression and concurrent p27 negativity have been reported. 40 Interestingly, FeLV-positive nondiseased cats show intense p27 expression in normal intestinal crypts with concurrent negativity to gp70.…”
Section: Discussionmentioning
confidence: 99%
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