Expression of WD Repeat Domain 5 (WDR5) is Associated with Progression and Reduced Prognosis in Papillary Thyroid Carcinoma

Xu, Wenchao; Wang, Lingling; An, Ying; Ye, Jing

doi:10.12659/msm.915847

Cited by 4 publications

(2 citation statements)

References 31 publications

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“…Impaired steroidogenic factor 1 (NR5A1) activity plays a significant role in mutant Y1 mouse adrenocortical tumor cells [23]. The expression of WD repeat domain 5 (WDR5) is relevant to papillary thyroid carcinoma progression and reduced prognosis [24]. Methylation of L1RE1, RARB, and RASSF1 serve as potential biomarkers for the differential diagnosis of lung cancer [25].…”

Section: Discussionmentioning

confidence: 99%

MTA2 is one of 14 Transcription factors predicting recurrence free survival in gastric cancer and promotes cancer progression by targeting MCM5

Li¹,

Guo²,

Yin³

et al. 2023

J. Cancer

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Gastric cancer (GC) is a leading cause of cancer-related death worldwide. Transcription factors (TFs) are essential gene expression regulators, and play critical roles in cancer development. However, the biological actions and prognostic value of TFs in GC remain unclear. In this study, we identified a risk model based on a 14-TF signature to predict recurrence-free survival in patients with GC. We further analyzed the ability of 14-TF to predict recurrence-free survival time in GC and found that a higher expression level of metastasis-associated protein 2 (MTA2) was associated with shorter overall survival and disease-free survival time in GC. Through in vitro and in vivo experiments, we demonstrated that MTA2 significantly promotes GC growth and metastasis. Furthermore, we identified MTA2 binding to the promoter of minichromosome maintenance deficient 5 (MCM5), thereby promoting GC progression. Overall, these findings strongly support the prognostic potential of the 14-TFs signature and suggest that targeting MTA2 may be a promising strategy to treat GC.

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Section: Discussionmentioning

confidence: 99%

MTA2 is one of 14 Transcription factors predicting recurrence free survival in gastric cancer and promotes cancer progression by targeting MCM5

Li¹,

Guo²,

Yin³

et al. 2023

J. Cancer

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show abstract

“…Expression of WD repeat domain 5 (WDR5) was relevant to progression and reduced prognosis in papillary thyroid carcinoma [24]. Methylation of L1RE1, RARB, and RASSF1 served as potential biomarkers for the differential diagnosis of lung cancer [25].…”

Section: Discussionmentioning

confidence: 99%

A 14 transcription factors-associated nomogram predicts the recurrence-free survival of gastric cancer

Ma¹,

Chen

Yang

et al. 2020

Preprint

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Background: We aimed to construct and validate a novel transcription factors (TFs) signature for the prediction of gastric cancer (GC) patient’s recurrence-free survival (RFS) from TCGA and Gene Expression Omnibus (GEO) database and improve the predictive ability of RFS in GC patients.Methods: We searched TCGA database and GEO database to obtain gene expression data and related clinical information for GC. In total, 722 TFs and 384 GC patients with intact clinical information were identified to develop a novel TF signature. All TFs were included in a univariate Cox regression model. We then used the least absolute shrinkage and selection operator (LASSO) Cox regression model which included only TFs with P < 0.05 in the univariate model to identify candidate TFs related to RFS. After further adjustment, multivariate Cox regression was performed based on the candidate TFs for the identification of TF signatures in the RFS evaluation of GC patients.Results: We successfully confirmed the high ability of the 14-TF panel for predicting GC patients’ RFS by receiver operating characteristic (ROC). AUCs at 1, 3, 5 years in internal validation dataset were 0.827, 0.817, 0.811, respectively. Some similar results were calculated in external validation dataset (0.808, 0.907, 0.813, respectively) and entire dataset (0.815, 0.849, 0.801, respectively). Besides, our model makes a good distinction between the high-risk group and the low-risk group. Furthermore, a nomogram was developed via risk score, sex, cancer status and tumor grade, and C-index, ROC, the calibration plots as well as decision curve analysis (DCA) demonstrated good ability and clinical application of the nomogram.Conclusions: We successfully established and validated a novel 14-TF-associated nomogram for predicting the RFS of GC.

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Chromatin readers of the WD-repeat containing protein family

Lorton,

Shechter

2024

Chromatin Readers in Health and Disease

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Expression of WD Repeat Domain 5 (WDR5) is Associated with Progression and Reduced Prognosis in Papillary Thyroid Carcinoma

Cited by 4 publications

References 31 publications

MTA2 is one of 14 Transcription factors predicting recurrence free survival in gastric cancer and promotes cancer progression by targeting MCM5

MTA2 is one of 14 Transcription factors predicting recurrence free survival in gastric cancer and promotes cancer progression by targeting MCM5

A 14 transcription factors-associated nomogram predicts the recurrence-free survival of gastric cancer

Chromatin readers of the WD-repeat containing protein family

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