Expression of α-smooth muscle actin in the periodontal ligament during post-emergent tooth eruption

Dorotheou, Domna; Bochaton‐Piallat, Marie‐Luce; Giannopoulou, Catherine; Kiliaridis, Stavros

doi:10.1177/0300060518769545

Cited by 6 publications

(2 citation statements)

References 33 publications

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“…The axial tooth movement is the physiological mechanism of tooth eruption. The loss of antagonists results in varying degrees of axial tooth movement in the post-emergent phase of tooth eruption ( 20 ). Moreover, diabetes mellitus(DM) was a common disease which affected tooth movement.…”

Section: Discussionmentioning

confidence: 99%

Remodeling of the periodontal ligament and alveolar bone during axial tooth movement in mice with type 1 diabetes

Zheng

et al. 2023

Front. Endocrinol.

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ObjectivesTo observe the elongation of the axial tooth movement in the unopposed rodent molar model with type 1 diabetes mellitus and explore the pathological changes of periodontal ligament and alveolar bone, and their correlation with tooth axial movement.MethodsThe 80 C57BL/6J mice were randomly divided into the streptozotocin(STZ)-injected group (n = 50) and the control group (n = 30). Mice in the streptozotocin(STZ)-injected group were injected intraperitoneal with streptozotocin (STZ), and mice in the control group were given intraperitoneal injection of equal doses of sodium citrate buffer. Thirty mice were randomly selected from the successful models as the T1DM group. The right maxillary molar teeth of mice were extracted under anesthesia, and allowed mandibular molars to super-erupt. Mice were sacrificed at 0, 3, 6,9, and 12 days. Tooth elongation and bone mineral density (BMD) were evaluated by micro-CT analysis(0,and 12 days mice). Conventional HE staining, Masson staining and TRAP staining were used to observe the changes in periodontal tissue(0, 3, 6, 9, and 12 days mice). The expression differences of SPARC, FGF9, BMP4, NOGGIN, and type I collagen were analyzed by RT-qPCR.ResultsAfter 12 days of tooth extraction, our data showed significant super-eruption of mandibular mouse molars of the two groups. The amount of molar super-eruption in the T1DM group was 0.055mm( ± 0.014mm), and in the control group was 0.157( ± 0.017mm). The elongation of the T1DM mice was less than that of the control mice(P<0.001). It was observed that the osteoclasts and BMD increased gradually in both groups over time. Compared with the control group, the collagen arrangement was more disordered, the number of osteoclasts was higher (P<0.05), and the increase of bone mineral density was lower(2.180 ± 0.007g/cm3 vs. 2.204 ± 0.006g/cm3, P<0.001) in the T1DM group. The relative expression of SPARC, FGF9, BMP4, and type I collagen in the two groups increased with the extension of tooth extraction time while NOGGIN decreased. The relative expression of all of SPARC, FGF9, BMP4, and type I collagen in the T1DM group were significantly lower, and the expression of NOGGIN was higher than that in the control group (P<0.05).ConclusionThe axial tooth movement was inhibited in type 1 diabetic mice. The result may be associated with the changes of periodontal ligament osteoclastogenic effects and alveolar bone remodeling regulated by the extracellular matrix and osteogenesis-related factors.

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Section: Discussionmentioning

confidence: 99%

Remodeling of the periodontal ligament and alveolar bone during axial tooth movement in mice with type 1 diabetes

Zheng

et al. 2023

Front. Endocrinol.

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“…Durante o estágio de erupção intraóssea o folículo é o grande regulador da erupção através dos mecanismos de reabsorção e formação óssea 4 . O ligamento periodontal possui importante papel no estabelecimento da oclusão do dente com seu antagonista 21,22 . Assim que alcança a posição oclusal funcional, as fibras do ligamento periodontal se organizam em feixes que suspendem o dente no alvéolo o que facilita a adaptação do dente às forças mastigatórias 22 .…”

Section: Ligamento Periodontalunclassified

Mecanismos de erupção dental: uma revisão de literatura

Debacker,

Hartmann

2023

Braz. J. Develop.

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A erupção dos dentes é um evento biológico que envolve diversos estágios até resultar no posicionamento do órgão na cavidade oral. Trata-se de um complexo processo que desde a formação intraóssea até atingir o plano funcional, envolve mudanças teciduais e anatômicas, ativação de vários genes e a liberação de fatores de crescimento e hormônios. O folículo dental, um tecido conjuntivo frouxo adjacente ao dente em formação, é o mais importante alvo de regulação no processo de erupção, pois a partir da liberação de seus produtos e interação com outros, o processo de remodelação óssea na cripta, formação do ligamento periodontal e crescimento radicular são iniciados. Historicamente, várias teorias foram elaboradas com o propósito de responder à pergunta de como os dentes erupcionam. Entre as principais teorias elaboradas, a do crescimento radicular, ligamento periodontal e a modulação do osso da cripta através dos processos de reabsorção e formação óssea são as mais embasadas para explicar o mecanismo. Essa revisão de literatura retoma, à vista disso, os conceitos previamente propostos para cada uma dessas teorias e busca relacionar com experimentos e pesquisas mais recentes nessa área. Além disso, associado às teorias são citadas correlações clínicas, como deficiências ou más formações, que reiteram a premissa da teoria para o mecanismo de erupção ou ainda se contrapõe ao princípio do mecanismo.

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Localization of α-smooth muscle actin in osteoblast differentiation during periodontal development

Takebe,

Sato,

Mizoguchi

et al. 2024

Cell Tissue Res

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Expression of α-smooth muscle actin in the periodontal ligament during post-emergent tooth eruption

Cited by 6 publications

References 33 publications

Remodeling of the periodontal ligament and alveolar bone during axial tooth movement in mice with type 1 diabetes

Remodeling of the periodontal ligament and alveolar bone during axial tooth movement in mice with type 1 diabetes

Mecanismos de erupção dental: uma revisão de literatura

Localization of α-smooth muscle actin in osteoblast differentiation during periodontal development

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