Expression patterns of the ADAMs in early developing chicken cochlea

Abstract

Members of the ADAM (a disintegrin and metalloprotease) family are type I transmembrane proteins involved in biological processes of proteolysis, cell adhesion, cell-matrix interaction, as well as in the intracellular signaling transduction. In the present study, expression patterns of seven members of the ADAM family were investigated at the early stages of the developing cochlea by in situ hybridization. The results show that each individual ADAM is expressed and regulated in the early developing cochlea. ADAM9, ADAM10, ADAM17, and ADAM23 are initially and widely expressed in the otic vesicle at embryonic day 2.5 (E2.5) and in the differential elements of the cochlear duct at E9, while ADAM12 is expressed in acoustic ganglion cells at E7. ADAM22 is detectable in cochlear ganglion cells as early as from E4 and in the basilar papilla from E7. Therefore, the present study extends our previous results and suggests that ADAMs also play a role in the early cochlear development.

NovelADAM9homozygous mutation in a consanguineous Egyptian family with severe cone-rod dystrophy and cataract

“…ADAM9 encodes a membrane-anchored protein implicated in various biological processes such as proliferation, proteolysis, cell adhesion, cell fusion and transduction signalling 13 . ADAM9 is expressed in different regions of the developing brain, spinal cord, retina and lens,14 and modifications of its expression have been observed in a wide variety of human cancers15 as well as in Alzheimer's disease 13. Recently, it has also been associated with CRD 6…”

Nonlinear Network Reconstruction from Gene Expression Data Using Marginal Dependencies Measured by DCOL

“…Yan et al found regional expression of the Adam10 in developing chicken cochlea [ 47 ]. Lin et al also showed that Adam10 is expressed and regulated in the early developing cochlea [ 48 ]. Some more genes such as Rbpj, that take part in the functional and morphological development of cochlear organ [ 49 ], also only found in the community of cochlear network.…”