Expression, Processing, and Properties of int‐2

Dickson, Clive; Fuller-Pace, Frances V.; Kiefer, Paul; Acland, Piers; MacAllan, David; Peters, Gordon

doi:10.1111/j.1749-6632.1991.tb49014.x

Cited by 35 publications

(17 citation statements)

References 30 publications

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“…Thereafter, seven Fgfs, Fgf3-Fgf9, were also identified as oncogenes or isolated as growth factors for cultured cells (Dickson et al, 1991;Yoshida et al, 1991;Goldfarb et al, 1991;Coulier et al, 1991;Aaronson et al, 1991;Tanaka et al, 1992;Miyamoto et al, 1993). FGFs 1-9 range in size from ϳ150 to 260 amino acid residues and have a conserved ϳ120-amino acid residue core with ϳ30 to 70% sequence identity (Ornitz and Itoh, 2001;Itoh and Ornitz, 2004).…”

Section: Identification Of the Mouse Fgf Gene Familymentioning

confidence: 99%

Functional evolutionary history of the mouse Fgf gene family

Itoh

Ornitz

2007

Developmental Dynamics

357

313

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Section: Identification Of the Mouse Fgf Gene Familymentioning

confidence: 99%

Functional evolutionary history of the mouse Fgf gene family

Itoh

Ornitz

2007

Developmental Dynamics

357

313

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“…FGF-1, FGF-2, and FGF-9 have no typical signal sequence in their amino termini (1,2,4), and so the pathway of release and sequestration of these FGFs is not clear. In contrast, other FGFs, FGF-3, FGF-4, FGF-5, FGF-6, FGF-7, and FGF-8, have typical signal sequences and are secreted proteins (3,(5)(6)(7)(8)(9). FGF-10 also has a hydrophobic amino terminus (ϳ40 amino acids), which may serve as a signal sequence, and appears to be a secreted protein (Fig.…”

Section: Isolation Of Fgf-related Cdna From Rat Embryos--mentioning

confidence: 99%

“…In contrast, most other FGFs are predominantly expressed in the embryo and show restricted expression patterns in the adult tissues as described below (3)(4)(5)(6)(7)(8)(9). FGF-3 is expressed in the embryo and in the adult brain and testis.…”

Section: Expression Of Fgf-10 Mrna In Embryonic and Adult Ratmentioning

confidence: 99%

“…The FGF family now consists of at least nine members, FGF-1 (aFGF), FGF-2 (bFGF), FGF-3 (int-2), FGF-4 (hst/kFGF), FGF-5, FGF-6, and FGF-7 (KGF), FGF-8 (AIGF), and FGF-9 (GAF) (1)(2)(3)(4)(5)(6)(7)(8)(9). The genes for FGF-3, FGF-4, FGF-5, and FGF-6 were first isolated as oncogenes (5)(6)(7)(8); FGF-7 was isolated as a mitogen for cultured keratinocytes (9); FGF-8 was isolated as an androgen-induced growth factor from mouse mammary carcinoma cells (3), and FGF-9 was isolated as a glia-activating factor from human glioma cells (4). These FGFs are expressed predominantly during embryonic development and are also expressed in restricted adult tissues.…”

mentioning

confidence: 99%

“…Although the physiological significance of most FGFs remains to be elucidated, FGFs appear to play important roles as peptide growth factors in both developing and adult tissues. Although members of the FGF family are of different sizes, they have a conserved ϳ120-amino acid residue core with ϳ30 -70% amino acid sequence identity (1)(2)(3)(4)(5)(6)(7)(8)(9). To isolate the cDNA encoding a novel FGF, we examined rat embryo cDNA amplified by the polymerase chain reaction with primers specific for conserved amino acid sequences within the FGF family.…”

mentioning

confidence: 99%

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Structure and Expression of the Rat mRNA Encoding a Novel Member of the Fibroblast Growth Factor Family

Yamasaki

Miyake

Tagashira

et al. 1996

Journal of Biological Chemistry

271

154

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We isolated the cDNA encoding a novel member of the fibroblast growth factor (FGF) family from rat embryos by homology-based polymerase chain reaction. The FGF-related cDNA encodes a protein of 215 amino acids (ϳ24 kDa), which has a conserved ϳ120-amino acid core with ϳ30 -60% amino acid sequence identity with the FGF family. This protein with a hydrophobic amino terminus appears to be a secreted protein. The cDNA was translated in a coupled in vitro transcription-translation system. The molecular mass of the translation product was observed to be ϳ26 kDa. The expression of the FGF-related mRNA in the rat embryo and adult tissues was determined by Northern analysis and in situ hybridization. The mRNA was expressed in several discrete regions of the embryo. In adult tissues, the mRNA was preferentially expressed in the lung. The expression profile of the FGF-related mRNA was different from those of other FGF family mRNAs. As this protein is the 10th documented protein related to FGFs, we tentatively term this protein FGF-10.

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Rat oligodendrocytes and astrocytes preferentially express fibroblast growth factor receptor-2 and -3 mRNAs

et al. 1996

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Fibroblast growth factors (FGFs) exert various effects on glial cells as well as on neurons in the brain. The mRNAs for four FGF receptors (FGFR‐1‐FGFR‐4) are expressed in the brain. Although FGFR‐1 and ‐4 mRNAs are preferentially expressed in neurons, FGFR‐2 and ‐3 mRNAs are preferentially expressed in glial cells. However, the glial cells that express these receptors remained to be identified. In this study, we found that oligodendrocytes and astrocytes in the brain preferentially expressed FGFR‐2 and FGFR‐3 mRNAs, respectively. The isoforms of immunoglobulin‐like domain III (IIIb and IIIc) of the receptors have crucial roles in ligand binding. We also determined the isoforms of FGFR‐2 and FGFR‐3 expressed in glial cells to be of type IIIc. The expression of FGFR‐2 IIIc and FGFR‐3 IIIc with different ligand specificities might play important roles in the various effects of FGFs on oligodendrocytes and astrocytes. © 1996 Wiley‐Liss, Inc.

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Expression, Processing, and Properties of int‐2

Cited by 35 publications

References 30 publications

Functional evolutionary history of the mouse Fgf gene family

Functional evolutionary history of the mouse Fgf gene family

Structure and Expression of the Rat mRNA Encoding a Novel Member of the Fibroblast Growth Factor Family

Rat oligodendrocytes and astrocytes preferentially express fibroblast growth factor receptor-2 and -3 mRNAs

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