Expression profiles of βTRCP1 and βTRCP2, and mutation analysis of βTRCP2 in gastric cancer

Saitoh, Tetsuroh; Katoh, Masaru

doi:10.3892/ijo.18.5.959

Cited by 44 publications

(50 citation statements)

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“…An involvement of hTRCP in tumorigenesis has been recently proposed for skin, gastric, and colon cancer (39)(40)(41). In addition, deregulated hTRCP expression has been linked to other tumor promoting pathways such as down-regulation of the disc large tumor suppressor (hDlg; ref.…”

Section: Discussionmentioning

confidence: 99%

Increased Expression of the E3-Ubiquitin Ligase Receptor Subunit βTRCP1 Relates to Constitutive Nuclear Factor-κB Activation and Chemoresistance in Pancreatic Carcinoma Cells

Müerköster

Arlt

Sipos³

et al. 2005

Cancer Research

113

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The permanent activation of the transcription factor nuclear factor-n nB (NF-n nB) in pancreatic cancer cells is associated with a profound resistance towards chemotherapy. In the present study, we show that chemoresistant pancreatic cancer cell lines exhibiting constitutive NF-n nB activity (i.e., PancTu-1, BxPc3, and Capan-1) express significantly elevated levels of the E3-ubiquitin ligase receptor subunit B BTRCP1, compared with pancreatic carcinoma cell lines lacking constitutive NF-n nB activity and chemoresistance (i.e., PT45-P1 and T3M4). If transfected with B BTRCP1, PT45-P1 cells exhibit an elevated NF-n nB activity and become less sensitive towards anticancer drug treatment (i.e., etoposide). Conversely, blockade of B BTRCP1 expression in PancTu-1 cells by transfection with a vector-expressed small interfering RNA reduces NF-K nB activation and chemoresistance. In PancTu-1 cells, B BTRCP1 expression is inhibited, at least in part, by the interleukin-1 (IL-1) receptor(I) antagonist, whereas stimulation of PT45-P1 cells with IL-1B B resulted in an increased expression of B BTRCP1, and transfection of this cell line with B BTRCP1 induced IL-1B B secretion in a NF-n nB-dependent fashion. Thus, via its close and mutual link to IL-1B B secretion, B BTRCP1 expression might substantially contribute to the persistent, IL-1B B-dependent activation of NF-n nB in pancreatic carcinoma cells. In support of this, B BTRCP1 expression is detectable at considerable levels in a great number of pancreatic ductal adenocarcinoma specimens, along with an intense staining for activated NF-n nB. Altogether, our findings of the elevated B BTRCP1 expression in pancreatic carcinoma cells pinpoint to another important mediator of constitutive NF-n nB activation and thereby of chemoresistance. (Cancer Res 2005; 65(4): 1316-24)

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Section: Discussionmentioning

confidence: 99%

Increased Expression of the E3-Ubiquitin Ligase Receptor Subunit βTRCP1 Relates to Constitutive Nuclear Factor-κB Activation and Chemoresistance in Pancreatic Carcinoma Cells

Müerköster

Arlt

Sipos³

et al. 2005

Cancer Research

113

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show abstract

“…42 FBXW1/ βTRCP1 and FBXW11/βTRCP2 are human homologs of Drosophila Slimb, which are components of E3-ubiquitin ligase complex. 43,44 Implication of FBXW1 and FBXW11 in the proteolytic cleavage of GLI family members remains unclear.…”

Section: Human Hedgehog Signaling Pathwaymentioning

confidence: 99%

Hedgehog signaling pathway and gastric cancer

Katoh¹,

Katoh²

2005

Cancer Biology & Therapy

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151

131

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“…SMO inactivation leads to formation of the cytoplasmic GLI degradation complex, in which GLI family members (GLI1, GLI2 and GLI3) are phosphorylated by casein kinase I· (CKI·), glycogen synthase kinase-3ß (GSK3ß) and protein kinase A (PKA) (16,17). Phosphorylated GLI is recognized by FBXW1/ßTRCP1 and FBXW11/ßTRCP2 (18)(19)(20) for ubiquitination, and ubiquitinated GLI is partially degraded to release its intact N-terminal half functioning as transcriptional repressor.…”

mentioning

confidence: 99%

Hedgehog signaling pathway and gastrointestinal stem cell signaling network (Review)

Katoh¹,

Katoh²

2006

Int J Mol Med

Self Cite

125

164

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Expression profiles of βTRCP1 and βTRCP2, and mutation analysis of βTRCP2 in gastric cancer

Cited by 44 publications

References 0 publications

Increased Expression of the E3-Ubiquitin Ligase Receptor Subunit βTRCP1 Relates to Constitutive Nuclear Factor-κB Activation and Chemoresistance in Pancreatic Carcinoma Cells

Increased Expression of the E3-Ubiquitin Ligase Receptor Subunit βTRCP1 Relates to Constitutive Nuclear Factor-κB Activation and Chemoresistance in Pancreatic Carcinoma Cells

Hedgehog signaling pathway and gastric cancer

Hedgehog signaling pathway and gastrointestinal stem cell signaling network (Review)

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