Expression profiling and characterization of 4200 genes cloned from primary neuroblastomas: identification of 305 genes differentially expressed between favorable and unfavorable subsets

Ohira, Miki; Morohashi, Aiko; Inuzuka, Hiroyuki; Shishikura, Tomotane; Kawamoto, Takemasa; Kageyama, Hajime; Nakamura, Yohko; Isogai, Emiko; Takayasu, Hajime; Sato, Shigeru; Suzuki, Yutaka; Sugano, Sumio; Goto, Takeshi; Sato, Shuji; Nakagawara, Akira

doi:10.1038/sj.onc.1206853

Cited by 72 publications

(62 citation statements)

References 41 publications

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“…20 Screening of 1,152 novel genes by reverse transcriptase (RT)-PCR revealed that 194 genes were expressed differentially between NBLs with favorable prognosis and those with unfavorable outcome. Among them, we detected a partial cDNA sequence (Nbla00660) corresponding to the human ortholog of tubulin tyrosine ligase (hTTL) gene.…”

Section: Cloning and Expression Of Httl Genementioning

confidence: 99%

“…To understand the molecular mechanism of distinct biology and tumorigenesis of NBL, we have previously performed a comprehensive approach to unveil the gene expression profiles among the NBL subsets. 20,21 We constructed the subset-specific oligo-capping cDNA libraries from the primary NBL tissues with favorable (stage 1, high expression of TrkA and a single copy of MYCN) and unfavorable (stage 3 or 4, decreased expression of TrkA and MYCN amplification) characteristics and randomly cloned 4,654 cDNAs. After adding the cDNAs obtained from the stage 4s NBL cDNA library to our NBL gene collection, we made an in-house cDNA microarray carrying 5,340 genes proper to NBL.…”

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confidence: 99%

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Low expression of human tubulin tyrosine ligase and suppressed tubulin tyrosination/detyrosination cycle are associated with impaired neuronal differentiation in neuroblastomas with poor prognosis

Kato

Miyazaki

Nakagawa

et al. 2004

Intl Journal of Cancer

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Section: Cloning and Expression Of Httl Genementioning

confidence: 99%

mentioning

confidence: 99%

Low expression of human tubulin tyrosine ligase and suppressed tubulin tyrosination/detyrosination cycle are associated with impaired neuronal differentiation in neuroblastomas with poor prognosis

Kato

Miyazaki

Nakagawa

et al. 2004

Intl Journal of Cancer

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“…[11][12][13] In addition to an increased gene copy number, high levels of nm23-H1 RNA and/or NDPK-A protein also occur in advanced neuroblastomas, and which are associated with poor prognosis. 8,9,[14][15][16] A high level of NDPK-A can occur in advanced neuroblastomas with or without MYCN amplification. 14 MYCN amplification is a frequent genetic alteration, occurring in~20% of patients with advanced neuroblastoma.…”

Section: Nm23-h1 Genetics and Prognosis Of Neuroblastomamentioning

confidence: 99%

NDPKA is not just a metastasis suppressor – be aware of its metastasis-promoting role in neuroblastoma

Tan

␣Chang

2018

Laboratory Investigation

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NDPK-A, encoded by nm23-H1 (also known as NME1) was the first metastasis suppressor discovered. Much of the attention has been focused on the metastasis-suppressing role of NDPK-A in human tumors, including breast carcinoma and melanoma. However, compelling evidence points to a metastasis-promoting role of NDPK-A in certain tumors such as neuroblastoma and lymphoma. To balance attention on this contrariety of NDPK-A in different cancer types, this review addresses the metastasis-promoting role of NDPK-A in neuroblastoma. Neuroblastoma is an embryonic tumor, arising from neural crest cells that fail to differentiate into the sympathetic nervous system. We summarize and discuss nm23-H1 genetics and the prognosis of neuroblastoma, structural and functional changes associated with the S120G mutation of NDPK-A, as well as the evidence supporting the role of NDPK-A as a metastasis promoter. Also discussed are the NDPK-A relevant molecular determinants of neuroblastoma metastasis, and metastasis-relevant neural crest development. Because of NDPK-A's dichotomous role in tumor metastasis as both a suppressor and a promoter, tumor genome/exome profiles are necessary to identify the molecular drivers of metastasis in the NDPK-A network for developing tumor-specific therapies.

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“…Gene expression profiling on NB specimens have been described as identifying the molecular signatures of high-risk and low-risk tumors [16][17][18] and novel prognostic markers. [19][20][21] The search for markers at the transcriptional level is less reliable than at the protein level, as there is a "long" and unpredictable route from RNA to proteins, and very often protein expression does not correlate with mRNA expression.…”

Section: Introductionmentioning

confidence: 99%

Comparative Proteomic Expression Profile in All-trans Retinoic Acid Differentiated Neuroblastoma Cell Line

et al. 2007

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Neuroblastoma (NB) is an infant tumor which frequently differentiates into neurons. We used twodimensional differential in-gel electrophoresis (2D-DIGE) to analyze the cytosolic and nuclear protein expression patterns of LAN-5 cells following neuronal differentiating agent all-trans-retinoic acid treatment. We identified several candidate proteins, from which G 2 and Prefoldin 3 may have a role on NB development. These results strength the use of proteomics to discover new putative protein targets in cancer.

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Expression profiling and characterization of 4200 genes cloned from primary neuroblastomas: identification of 305 genes differentially expressed between favorable and unfavorable subsets

Cited by 72 publications

References 41 publications

Low expression of human tubulin tyrosine ligase and suppressed tubulin tyrosination/detyrosination cycle are associated with impaired neuronal differentiation in neuroblastomas with poor prognosis

Low expression of human tubulin tyrosine ligase and suppressed tubulin tyrosination/detyrosination cycle are associated with impaired neuronal differentiation in neuroblastomas with poor prognosis

NDPKA is not just a metastasis suppressor – be aware of its metastasis-promoting role in neuroblastoma

Comparative Proteomic Expression Profile in All-trans Retinoic Acid Differentiated Neuroblastoma Cell Line

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