Expressions of lipoprotein receptors and cholesterol efflux regulatory proteins during luteolysis in bovine corpus luteum

Horihata, Kei; Yoshioka, Shin; Sano, Masahiro; Yamamoto, Yuki; Kimura, Koji; Skarzynski, Dariusz J.; Okuda, Kiyoshi

doi:10.1071/rd15538

Cited by 7 publications

(3 citation statements)

References 27 publications

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“…Nfkbia and Adam8 are poorly understood in the context of aneurysm rupture, but Rgs2 is known to be upregulated in response to high wall shear stress and is associated with development of hypertension, which is a major risk factor for ICA development and rupture ( Cañes et al ., 2021 ; Dolan et al ., 2012 ; Heximer et al ., 2003 ; Leng et al ., 2021 ; Tang et al ., 2003 ). ATP binding cassette subfamily A member 1 ( Abca1 ) is part of the peroxisome proliferator-activated receptor gamma (PPAR-gamma) pathway that mediates cholesterol influx in the ovary, is increased in early luteal stages, and is associated with altered fertility when mutated ( Horihata et al ., 2017 ; Miettinen, Rayburn & Krieger, 2001 ; Puttabyatappa, VandeVoort & Chaffin, 2010 ). It plays a similar cholesterol-transporting role in arterial walls ( Bekelis et al ., 2016 ; Ollikainen et al ., 2016 ; Synowiec et al ., 2016 ).…”

Section: Features Of Intracranial Aneurysm Formation and Rupture That...mentioning

confidence: 99%

Common mechanisms of physiological and pathological rupture events in biology: novel insights into mammalian ovulation and beyond

2023

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Ovulation is a cyclical biological rupture event fundamental to fertilisation and endocrine function. During this process, the somatic support cells that surround the germ cell undergo a remodelling process that culminates in breakdown of the follicle wall and release of a mature egg. Ovulation is driven by known proteolytic and inflammatory pathways as well as structural alterations to the follicle vasculature and the fluid‐filled antral cavity. Ovulation is one of several types of systematic remodelling that occur in the human body that can be described as rupture. Although ovulation is a physiological form of rupture, other types of rupture occur in the human body which can be pathological, physiological, or both. In this review, we use intracranial aneurysms and chorioamniotic membrane rupture as examples of rupture events that are pathological or both pathological and physiological, respectively, and compare these to the rupture process central to ovulation. Specifically, we compared existing transcriptomic profiles, immune cell functions, vascular modifications, and biomechanical forces to identify common processes that are conserved between rupture events. In our transcriptomic analysis, we found 12 differentially expressed genes in common among two different ovulation data sets and one intracranial aneurysm data set. We also found three genes that were differentially expressed in common for both ovulation data sets and one chorioamniotic membrane rupture data set. Combining analysis of all three data sets identified two genes (Angptl4 and Pfkfb4) that were upregulated across rupture systems. Some of the identified genes, such as Rgs2, Adam8, and Lox, have been characterised in multiple rupture contexts, including ovulation. Others, such as Glul, Baz1a, and Ddx3x, have not yet been characterised in the context of ovulation and warrant further investigation as potential novel regulators. We also identified overlapping functions of mast cells, macrophages, and T cells in the process of rupture. Each of these rupture systems share local vasoconstriction around the rupture site, smooth muscle contractions away from the site of rupture, and fluid shear forces that initially increase and then decrease to predispose one specific region to rupture. Experimental techniques developed to study these structural and biomechanical changes that underlie rupture, such as patient‐derived microfluidic models and spatiotemporal transcriptomic analyses, have not yet been comprehensively translated to the study of ovulation. Review of the existing knowledge, transcriptomic data, and experimental techniques from studies of rupture in other biological systems yields a better understanding of the physiology of ovulation and identifies avenues for novel studies of ovulation with techniques and targets from the study of vascular biology and parturition.

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Section: Features Of Intracranial Aneurysm Formation and Rupture That...mentioning

confidence: 99%

Common mechanisms of physiological and pathological rupture events in biology: novel insights into mammalian ovulation and beyond

2023

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“…Ovaries were immediately disinfected once in 70% ethanol and then cleaned again with saline a minimum of three times in the laboratory. According to their morphology, one skillful operator split the CLs basically into three phases: the early (days 1-5), developed and mid (days 6-11), and late luteal phase (days 12-16) stages (Rakesh et al, 2013;Horihata et al, 2016).…”

Section: Classificationmentioning

confidence: 99%

Expression Pattern of Apoptotic Genes During Different Stages of Corpus Luteum Development in Egyptian Buffaloes

Galal¹,

Ibrahim²,

Mahmoud³

et al. 2022

AAVS

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B uffaloes (Bubalus bubalis) play an important part in many poor countries. They are used for agricultural economies, producing milk, meat, and draught force (Minervino et al., 2020). One of the greatest constraints in the exploitation of the production potential of buffaloes are its inherently lower reproductive efficiency, manifested by es-trus with low behavioral expression and/or not associated with ovulation, postponed sexual maturity, lower conception rates, and longer calving intervals (Baithalua et al., 2013).The corpus luteum (CL), a dynamic endocrine gland, controls the estrous cycle, embryonic development, implantation, and produce progesterone (P4), which is essential for research Article Abstract | It is fair to know how corpus luteum (CL) is a maestro of regulation of estrus cycle in Egyptian buffaloes. Hence, the study of molecular control of the CL in Egyptian buffaloes let us to know the mechanisms of this regulation. We aimed to (1) figure out the expression profile of apoptotic genes (TNF α -BAX -CASP3 -FASLG -AGTR2 -and NOS2) mRNAs during early, mid, and late stages of CL and (2) clarify the accompanied changes in progesterone (P4), nitric oxide (NO) concentrations and histological evaluation through different stages of CL in buffaloes. Forty five paired samples of ovarian tissue from buffaloes were obtained from slaughterhouse. Ovaries were collected and CLs were classified morphologically into three stages: early, mid and late stages. Moreover, the CLs were frozen at -80 °C for NO estimation in CLs homogenate, RNA isolation and gene expression. Blood samples were obtained for P4 serum levels estimation. Results showed a significant rise of TNF α mRNA during late stage of CL and increase the expression of CASP3, FASLG and AGTR2 mRNAs during mid-stage of CL. Furthermore, NOS2 mRNA was raised during early stage of CL. Surprisingly, NO in CL homogenate was raised through early and late stages of CL. Additionally, P4 increased in mid-stage of CL. Taken together, the fine tuning between apoptotic genes (TNF α -BAX -CASP3 -FASLG -AGTR2 -and NOS2) is required for proper functions of CL in Egyptian buffaloes. Thus, it might be concluded that expression pattern of apoptotic genes is changed according to the stage of CL.

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“…The CL can be divided into cyclical and pregnancy CLs. If pregnancy does not occur, the CL will degenerate into a white body under the action of prostaglandin F2α (PGF 2α ) and prolactin (PRL), and then the female animal will enter the next round of the estrus cycle [1][2][3]. Progesterone (P 4 ), secreted by the CL, plays a crucial role in regulating the estrous cycle and maintaining pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Hand2os1 Regulates the Secretion of Progesterone in Mice Corpus Luteum

Jia

Liu

Gong

et al. 2022

Veterinary Sciences

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The corpus luteum plays a key role in pregnancy maintenance and estrous cycle regulation by secreting progesterone. Hand2os1 is an lncRNA located upstream of Hand2, with which a bidirectional promoter is shared and is involved in the regulation of cardiac development and embryo implantation in mice. The aim of this study was to investigate the expression and regulation of Hand2os1 in the ovaries. Here, we used RNAscope to detect differential expression of Hand2os1 in the ovaries of cycling and pregnant mice. Hand2os1 was specifically detected in luteal cells during the proestrus and estrus phases, showing its highest expression in the corpus luteum at estrus. Additionally, Hand2os1 was strongly expressed in the corpus luteum on day 4 of pregnancy, but the positive signal progressively disappeared after day 8, was detected again on day 18, and gradually decreased after delivery. Hand2os1 significantly promoted the synthesis of progesterone and the expression of StAR and Cyp11a1. The decreased progesterone levels caused by Hand2os1 interference were rescued by the overexpression of StAR. Our findings suggest that Hand2os1 may regulate the secretion of progesterone in the mouse corpus luteum by affecting the key rate-limiting enzyme StAR, which may have an impact on the maintenance of pregnancy.

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Expressions of lipoprotein receptors and cholesterol efflux regulatory proteins during luteolysis in bovine corpus luteum

Cited by 7 publications

References 27 publications

Common mechanisms of physiological and pathological rupture events in biology: novel insights into mammalian ovulation and beyond

Common mechanisms of physiological and pathological rupture events in biology: novel insights into mammalian ovulation and beyond

Expression Pattern of Apoptotic Genes During Different Stages of Corpus Luteum Development in Egyptian Buffaloes

Hand2os1 Regulates the Secretion of Progesterone in Mice Corpus Luteum

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