Extended cyclic fed-batch tylosin fermentations

Gray, Peter P.; Vu-Trong, K.

doi:10.1007/bf01033197

Biotechnol Lett

1987

DOI: 10.1007/bf01033197

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Extended cyclic fed-batch tylosin fermentations

Peter P. Gray

K. Vu-Trong

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Cited by 2 publications

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“…3), a strategy by which series of FBFs can be achieved if aseptic conditions are maintained and if the respective product (cells and/or metabolites) can be attained (10,11,23,43). The volumetric poly(3HB) productivities achieved during CFBF were about five times higher than those attained by the other cultivation techniques investigated in this study (Table 1).…”

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confidence: 58%

High-Cell-Density Cyclic Fed-Batch Fermentation of a Poly(3-Hydroxybutyrate)-Accumulating Thermophile, Chelatococcus sp. Strain MW10

Ibrahim

Steinbüchel

2010

Appl Environ Microbiol

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Fermentations, which are performed with thermophilic microorganisms, are energy-efficient processes because few cooling efforts are necessary. Moreover, thermophilic fermentations are self-heated systems because the heat generated by the cell's metabolism during high-cell-density (HCD) growth (28, 49) and also by stirring can be used for providing heat to the fermentation process itself. Thus, both heating and cooling costs are lowered (14, 46). Additionally, unlike when mesophilic bacteria are used in fermentations, sterile conditions may not be essential during a process involving thermophilic bacteria (41, 42).Unfortunately, thermophiles usually grow to only low cell densities. Recently, with the use of advanced fermentation technology, a few thermophilic bacteria were cultivated successfully, yielding HCD growth and enhanced product formation (15,25). In industry, HCD cultivation is often a prerequisite for high productivity during fermentations, in particular if intracellular compounds are being produced. HCD cultivations are enhanced cultivations of the microbial strain achieving cell dry weight (CDW) concentrations exceeding 100 g/liter. However, a lower cell density can be regarded as an HCD as well, depending on the microorganism and its cultivation conditions (39). In general, HCD cultivations represent a 10-to 20-fold increase in growth in comparison to normal cell density growth. Problems encountered by HCD cultivation are numerous, such as partial O 2 pressure (pO 2 ) deficiency, byproduct formation, and/or metabolic heat production. As a result of the growing industrial interest in HCD, many attempts have been made to develop HCD fermentations, for example, by improving potent strains and/or using different types of bioreactors and cultivation strategies (39).The most industrially applicable technique is fed-batch fer-

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confidence: 58%

High-Cell-Density Cyclic Fed-Batch Fermentation of a Poly(3-Hydroxybutyrate)-Accumulating Thermophile, Chelatococcus sp. Strain MW10

Ibrahim

Steinbüchel

2010

Appl Environ Microbiol

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Aureobasidium pullulans in applied microbiology: A status report

Deshpande¹,

Rale²,

Lynch³

1992

Enzyme and Microbial Technology

174

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Extended cyclic fed-batch tylosin fermentations

Cited by 2 publications

References 4 publications

High-Cell-Density Cyclic Fed-Batch Fermentation of a Poly(3-Hydroxybutyrate)-Accumulating Thermophile, Chelatococcus sp. Strain MW10

High-Cell-Density Cyclic Fed-Batch Fermentation of a Poly(3-Hydroxybutyrate)-Accumulating Thermophile, Chelatococcus sp. Strain MW10

Aureobasidium pullulans in applied microbiology: A status report

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