Extended in vivo blood circulation time of fluorinated liposomes

Santaella, Catherine; Frézard, Frédéric; Vierling, Pierre; Riess, Jean G.

doi:10.1016/0014-5793(93)80860-w

Cited by 68 publications

(20 citation statements)

References 15 publications

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“…41 Vesicles made from fluorinated amphiphiles generally withstand heat sterilization, have extended shelf lives, and are less permeant than those made from hydrogenated analogues. 43 43 …”

Section: Microcontainers For Controlled Deliverymentioning

confidence: 99%

Fluorocarbons and Fluorosurfactants for In Vivo Oxygen Transport (Blood Substitutes), Imaging, and Drug Delivery

Riess¹,

Krafft²

1999

MRS Bull.

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The development of biomaterials to treat, repair, or reconstruct the human body is an increasingly important component of materials research. Collaboration between materials researchers and their industrial and clinical partners is essential for the development of this complex field. To demonstrate the importance of these interactions, two articles in this issue focus on advances in biomaterials relating to the use of colloidal systems for transport, drug delivery, and other medical applications. These articles were coordinated by Dominique Muster (Université Louis Pasteur, Strasbourg) and Franz Burny (Hôpital Erasme, Brussels). The following is the first of these two articles.A large variety of colloidal Systems involving highly fluorinated components have been prepared and investigated in recent years. These fluorinated Systems comprise diverse ty pes of emulsions (e.g., direct, reverse, and multiple emulsions; microemulsions; gel emulsions; waterless emulsions) with a fluorocarbon phase (and often a fluorinated Surfactant), and a ränge of self-assemblies (vesicles, tubules, helices, ribbons, etc.) made from fluorinated amphiphiles. Fluorinated Langmuir films and fluorinated black lipid membranes (BLMs) also have been investigated.Research in this area was driven by the potential applications of such materials in medicine and biology. Fluorocarbon-based products are being developed as injectable oxygen carriers (“blood Substitutes”), media for liquid Ventilation, drug delivery Systems, and contrast agents for ultrasound imaging. One such agent has recently been approved for use in Europe and the United States. Several more products are in an advanced stage of clinical evaluation, and others are in various stages of preclinical development. From a more fundamental Standpoint, these materials are being investigated for assessing and understanding the impact that fluorinated components have on the formation, stability, structure, and properties of colloida l Systems in comparison with their hydrocarbon counterparts. The attention given to fluorinated colloids prompted the synthesis of numerous new families of fluorinated amphiphiles, which were to become components of such colloids.

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“…41 Vesicles made from fluorinated amphiphiles generally withstand heat sterilization, have extended shelf lives, and are less permeant than those made from hydrogenated analogues. 43 43 …”

Section: Microcontainers For Controlled Deliverymentioning

confidence: 99%

Fluorocarbons and Fluorosurfactants for In Vivo Oxygen Transport (Blood Substitutes), Imaging, and Drug Delivery

Riess¹,

Krafft²

1999

MRS Bull.

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“…6 The pharmacokinetic behaviour of liposomes depends on the route of injection 42 such as intraperitoneal, subcutaneous or intramuscular route. Lasic and Papahadjopoulos 43 have shown that coating the liposome surface with polyethyleneglycol and other hydrophobic part of phospholipids 44 substantially prolongs the half-life of liposomes in the blood.…”

Section: Pharmacokinetic Considerationsmentioning

confidence: 99%

Current trends in the production and biomedical applications of liposomes: a review

Uhumwangho¹,

Okor²

2009

Journal of Medicine and Biomedical Research

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A review of literature was carried out to determine methods of production of liposomes, their stability, biodistribution and their uses as drug delivery systems. The conventional method of preparing liposomes is basically for the multilamellar vesicles (MLVs). However, other methods are used to reduce the size of these MLVs to small unilamellar vesicles (SUVs) so as to increase their plasma lifetime and consequently increase the possibility of achieving greater tissue localisation. Some of these methods of size reduction are sonication and high pressure extrusion. Each of these methods has its own advantages and disadvantages. Large unilamellar vesicles (LUVs), on the other hand, are prepared mainly by detergent removal method and reverse phase extrusion technique. There are also improved pharmacokinetic properties with liposomal drugs compared to free drugs, though some formulation factors affect the release kinetics of the liposomal drugs. The review also shows that liposomes have a lot of biomedical applications and uses. They have been used in drug targeting, oral delivery of vaccines, insulins, peptides and some compounds, which are usually degraded in the gastrointestinal tract. It has also found application in topical therapy especially in the eye and lungs. Other areas of application are in cancer chemotherapy and treatment of human immunovirus (HIV) infection. The control of the stability of liposomes is an essential prerequisite for effective use as drug carriers. Leakage of the liposome is attributable mainly to differences in lamellar structure. For instance, MLVs are less prone to leakage than ULVs. The use of a combination of saturated phospholipid and cholesterol in the formulation of the liposomes has also been found to enhance stability with lower tendency to leakage.

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“…Recent works have shown that coating the liposome surface with polyethyleneglycol and other hydrophilic polymers (31), or chemically modifying the hydrophobic part of phospholipids (23,32), substantially prolongs the half-life of liposomes in the blood. Furthermore, these liposomes have a propensity to accumulate in implanted tumors at levels compared to other non-MPS tissues.…”

Section: In Vivo Fate Of Liposomesmentioning

confidence: 99%

Liposomes: from biophysics to the design of peptide vaccines

Frézard

1999

Braz J Med Biol Res

111

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Liposomes (lipid-based vesicles) have been widely studied as drug delivery systems due to their relative safety, their structural versatility concerning size, composition and bilayer fluidity, and their ability to incorporate almost any molecule regardless of its structure. Liposomes are successful in inducing potent in vivo immunity to incorporated antigens and are now being employed in numerous immunization procedures. This is a brief overview of the structural, biophysical and pharmacological properties of liposomes and of the current strategies in the design of liposomes as vaccine delivery systems.

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Extended in vivo blood circulation time of fluorinated liposomes

Cited by 68 publications

References 15 publications

Fluorocarbons and Fluorosurfactants for In Vivo Oxygen Transport (Blood Substitutes), Imaging, and Drug Delivery

Fluorocarbons and Fluorosurfactants for In Vivo Oxygen Transport (Blood Substitutes), Imaging, and Drug Delivery

Current trends in the production and biomedical applications of liposomes: a review

Liposomes: from biophysics to the design of peptide vaccines

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