Extension of Increased Atherosclerotic Wall Thickness Into High Shear Stress Regions Is Associated With Loss of Compensatory Remodeling

Abstract

Background-Atherosclerosis

Cross-Sectional Relations of Multiple Biomarkers From Distinct Biological Pathways to Brachial Artery Endothelial Function

“…Because flow velocity is associated with shear stress and artery diameters have been shown to remodel to keep wall shear stress constant (the Glagov phenomenon), 28,29 we performed secondary analyses in which we included baseline brachial artery diameter as a covariate for 2 measures of vascular function: baseline mean flow velocity and hyperemic mean flow velocity.…”

Shear-sensitive MicroRNA-34a Modulates Flow-dependent Regulation of Endothelial Inflammation

“…In normal human coronary arteries, the time-averaged wall shear stress was previously determined to be ,16 dyn/cm 2 (Joshi et al, 2004;Stone et al, 2003;Wentzel et al, 2003). By contrast, the shear stress overlying plaques was .50 dyn/cm 2 (Gijsen et al, 2008;Stone et al, 2003).…”

Prediction of the Localization of High-Risk Coronary Atherosclerotic Plaques on the Basis of Low Endothelial Shear Stress

“…Human and animal studies have shown that atherosclerotic regions with low ESS exhibit expansive remodeling. 1,4 -6,11,18 Wentzel et al 18 showed that as the atherosclerotic plaques grow and encroach into the lumen, the local ESS increases over the whole arterial cross section, including the nondiseased wall, which thereby promotes nitric oxidedependent compensatory expansive remodeling. However, the factors that determine whether the expansive remodeling response to atherosclerosis becomes either compensatory or excessive, with consequent implications fostering high-risk plaques, have not been studied previously.…”