Extensive genetic heterogeneity and molecular characteristics of emerging astroviruses causing fatal gout in goslings

Cui, Hao; Mu, Xinhao; Xu, Xin; Ji, Jun; Ma, Ke; Leng, Chaoliang; Yao, Lunguang; Kan, Yunchao; Bi, Yanlan; Xie, Qingmei

doi:10.1016/j.psj.2022.101888

Cited by 8 publications

(10 citation statements)

References 27 publications

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“…Several amino acid mutations in the Cap protein have been identified in this study, including Y36H and E456D. In addition, other amino acid mutations in Cap protein have also been reported previously, such as Q229P and A614T [23,24], and whether these mutations influence the antigenicity of the GoAstV needs further investigation. Two distant clades of the GoAstV have been identified, and the homology of the whole genome and Cap protein between GoAstV-1 and GoAstV-2 is only 58.0% and 42.5%, respectively.…”

Section: Discussionsupporting

confidence: 65%

“…Niu et al reported that the infection rate of the GoAstV in clinical samples collected from six provinces in North China was 81.5% [9]. In addition, the epidemiology of the GoAstV in goslings have been conducted by several study groups in different regions, and the results showed that the GoAstV infections in goslings are widespread [23][24][25]. In the present study, the epidemiology of the GoAstV in goslings in southern China was examined, and the results showed that the GoAstV is also prevalent in goslings in southern China.…”

Section: Discussionmentioning

confidence: 99%

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Insight into the Epidemiology and Evolutionary History of Novel Goose Astrovirus-Associated Gout in Goslings in Southern China

Hou

Liu

et al. 2022

Viruses

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A novel gout disease, characterized by visceral urate deposition with high-mortality, with outbreaks in goslings in China since 2016 was caused by a novel goose astrovirus (GoAstV) and resulted in serious economic loss. However, the epidemiology and variation of the GoAstV in goslings in southern China and its evolutionary history as well as the classification of the GoAstV are unclear. In the present study, systematic molecular epidemiology, and phylogenetic analyses of the GoAstV were conducted to address these issues. Our results showed that the GoAstV is widespread in goslings in southern China, and the genomes of six GoAstV strains were obtained. Two amino acid mutations (Y36H and E456D) were identified in capsid proteins in this study, which is the dominant antigen for the GoAstV. In addition, the GoAstV could be divided into two distinct clades, GoAstV-1 and GoAstV-2, and GoAstV-2 is responsible for gout outbreaks in goslings and could be classified into Avastrovirus 3 (AAstV-3), while GoAstV-1 belongs to Avastrovirus 1 (AAstV-1). Moreover, the emergence of GoAstV-2 in geese was estimated to have occurred in January 2010, approximately 12 years ago, while GoAstV-1 emerged earlier than GoAstV-2 and was estimated to have emerged in April 1985 based on Bayesian analysis. The mean evolutionary rate for the GoAstV was also calculated to be approximately 1.42 × 10−3 nucleotide substitutions per site per year. In conclusion, this study provides insight into the epidemiology of the GoAstV in goslings in southern China and is helpful for understanding the origin and evolutionary history as well as the classification of the GoAstV in geese.

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Section: Discussionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Insight into the Epidemiology and Evolutionary History of Novel Goose Astrovirus-Associated Gout in Goslings in Southern China

Hou

Liu

et al. 2022

Viruses

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“…3.4.4b H5N8 virus (Pyankova et al, 2021). In June 2021, 2,782 outbreaks of H5N8 were reported, causing the mortality or destruction of approximately 38 million poultry in more than 25 countries (Cui et al, 2022). 1 In conclusion, the spread of High pathogenic AI H5N8 viruses has raised serious issues for the security and conservation of animals, poultry, and even public health (Shi and Gao, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…Orthocoronavirinae, known as CoV, is one of the two subfamilies in Coronavirinae and consists of four genera of alpha-, beta-, gamma-, and delta-coronaviruses that infect mammalian or avian hosts, especially those specific to species (Woo et al, 2012). The two former CoV members only infect mammals, and the two latter CoVs dominantly infect birds, with some exceptions for mammalian infection (Woo et al, 2012;Ji et al, 2022). According to current CoV databases, almost all human CoVs, with HcoV-OC43 and HKU1 as the exceptional origins of rodents (Forni et al, 2017), have been indicated to have originated in bats Ruiz-Aravena et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Viral emerging and re-emerging diseases: Basic understanding and future intervention strategies

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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“…RFS is essential to determine that RNA dependent RNA polymerase (RdRp) can be translated normally. The non-structural proteins of goose astrovirus are encoded by ORF1a and ORF1b, including transmembrane domain (TM), serine protease motif (Pro), nuclear localization signal (NLS) and RNA dependent RNA polymerase (RdRp) ( Cui et al, 2022 ). The viral capsid protein encoded by ORF2 has significant diversity in the genome of goose astrovirus, which is composed of conservative region and variable region ( Fei et al, 2022 ).…”

Section: Viral Genome Characteristics and Viral Protein Functionmentioning

confidence: 99%

Infection and innate immune mechanism of goose astrovirus

Jiang

Cheng

et al. 2023

Front. Microbiol.

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Goose astrovirus (GAstV, genus Avian Astrovirus, family Astrovirus) was first discovered in 2005, but was not considered as a pathogen of gosling gout until 2016. Since then, goose astrovirus has erupted in Chinese goslings, causing at most 50% of gosling deaths. By December 2022, the disease had become epidemic and prevailed in goose farms in Jiangsu, Shandong, Anhui, Henan, Guangdong, Liaoning, Sichuan and other places in China. The disease mainly affects goslings within 3 weeks old. The typical symptoms of goose astrovirus are large deposits of urate in the viscera, joint cavity and ureter surface of infected goslings. Goose astrovirus infection can trigger high levels of iNOS, limiting goose astrovirus replication. The ORF2 domain P2 of the goose astrovirus activates the OASL protein, limiting its replication. Goose astrovirus can also activate pattern recognition receptors (RIG-I, MDA-5, TLR-3), causing an increase in MHC-Ia, MHC-Ib and CD81 mRNA, activating humoral and cellular immunity, thereby hindering virus invasion. Goose astrovirus also regulates the activation of IFNs and other antiviral proteins (Mx1, IFITM3, and PKR) in the spleens and kidneys to inhibit viral replication. The innate immune response process in goslings also activates TGF-β, which may be closely related to the immune escape of goose astrovirus. Gaining insight into the infection and innate immune mechanism of goose astrovirus can help researchers study and prevent the severe disease in goslings better.

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Extensive genetic heterogeneity and molecular characteristics of emerging astroviruses causing fatal gout in goslings

Cited by 8 publications

References 27 publications

Insight into the Epidemiology and Evolutionary History of Novel Goose Astrovirus-Associated Gout in Goslings in Southern China

Insight into the Epidemiology and Evolutionary History of Novel Goose Astrovirus-Associated Gout in Goslings in Southern China

Viral emerging and re-emerging diseases: Basic understanding and future intervention strategies

Infection and innate immune mechanism of goose astrovirus

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