Extensive Grover's-like eruption with lentiginous 'freckling': report of two cases

Cooper, Susan M.; Dhittavat, J.; Millard, P. R.; Burge, Susan

doi:10.1111/j.1365-2133.2004.05778.x

Cited by 20 publications

(20 citation statements)

References 12 publications

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“…The case reports of Galli-Galli disease are summarized in Table I. [1][2][3][4] According to the reported cases, the age range of presentation with Galli-Galli disease is 15 to 56 years. Seven of the 10 reported cases were male and 3 of the patients were female.…”

Section: Resultsmentioning

confidence: 99%

Galli-Galli disease: A case report with review of the literature

Gilchrist

Jackson

Morse

et al. 2008

Journal of the American Academy of Dermatology

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Section: Resultsmentioning

confidence: 99%

Galli-Galli disease: A case report with review of the literature

Gilchrist

Jackson

Morse

et al. 2008

Journal of the American Academy of Dermatology

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“…Cooper et al 17 were the first to pay attention to the lentiginous pattern we have described. They published 2 cases combining an extensive GD-like eruption and lentiginous freckling and considered the lesions to be sun induced, although in our opinion, extensive thigh or leg involvement in a skin type III patient in the absence of regular sun bathing raises some questions about this assumption.…”

Section: Discussionmentioning

confidence: 95%

Grover Disease: A Reappraisal of Histopathological Diagnostic Criteria in 120 Cases

Fernández‐Figueras

Puig²,

Cannata³

et al. 2010

The American Journal of Dermatopathology

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Grover disease (GD) is a rather common papular pruritic dermatosis that can be transient, persistent, or asymptomatic. The microscopic diagnosis of clinically suspected lesions can be challenging because GD can adopt different patterns, and involved areas are generally admitted to be mostly focal. The histopathologic hallmark of the disease is acantholysis, frequently combined with dyskeratosis, which confers the lesions an appearance similar to Darier disease, Hailey-Hailey disease, or pemphigus. Eczematous features can be observed as well. In this study of 120 consecutive cases of GD, we have found a sex and age incidence similar to what has been previously described, with no obvious seasonal influence, but careful evaluation of their microscopic features suggests that the histopathological diagnostic criteria of GD should be expanded. Specifically, in addition to the commonly described GD findings, we have detected cases with porokeratosis-like oblique columns of parakeratosis, lesions showing a nevoid or lentiginous silhouette, intraepidermal vesicular lesions, lichenoid changes with basal vacuolization and dyskeratosis, and dysmaturative foci with keratinocyte atypia. Moreover, quite often the dermal infiltrate was composed not only of lymphocytes intermingled with eosinophils, but also of neutrophils. In many cases, the capillary vessels showed hints of vascular damage including endothelial tumefaction due to cytoplasmatic edema and erythrocyte extravasation. Finally, because involved areas were larger than 2 mm in more than 50% of our cases, we should assume that GD lesions are not always as small as commonly claimed. Awareness of the patterns newly described herein may be important to avoid underdiagnosis of GD and may contribute to understand the pathogenesis of this acantholytic disease.

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“…Recent cases of a widespread form of ''Grover disease with sun-induced lentiginous freckling'' and of a "persistent acantholytic dermatosis with extensive lentiginous ''freckling'' have been described, suggesting that persistent acantholytic dermatosis may be a new etiology of profuse lentigines. 13,14 Actually, these cases are considered as examples of the atypical variant of Galli-Galli disease. 3,4 Very recently, we have acquired further evidences that Galli-Galli disease is merely an acantholytic variant of DDD in a survey conducted on a series of patients.…”

Section: Discussionmentioning

confidence: 99%

“…13,14 DDD is a rare autosomal dominant condition, arising from early adolescence to late adult life, whose clinical features are characterized by reticulate hyperpigmentation of the flexural areas, associated with keratotic papules, pitted perioral scars, and comedo-like lesions on the face and neck. Characteristic histopathological features include filiform epithelial downgrowths of the rete ridges of interfollicular epidermis and infundibular follicular wall with basilar hyperpigmentation and dermal melanosis.…”

Section: Discussionmentioning

confidence: 99%

Atypical Variant of Galli–Galli Disease (Grover-Like Eruption With Lentiginous Freckling) in a Liver Transplant Patient

Rongioletti

Fausti

Christana

et al. 2011

The American Journal of Dermatopathology

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Galli-Galli disease is considered as a rare variant of Dowling-Degos disease, sharing the same clinical features of reticulate hyperpigmentation of the flexures. Histopathologically, there is acantholysis and suparabasal lacunae. Grover disease (transient acantholytic dermatosis) is a transient dermatosis which clinically presents as an eruption of erythematous excoriated papules located on the trunk and histologically with dyskeratosis and acantholysis. Grover disease has occasionally been reported in patients with chronic renal failure, human immunodeficiency virus infection, hematological malignancies, bone marrow allotransplantation, and renal transplantation. We report herein a case of atypical variant of Galli-Galli disease occurring in a liver transplant patient in whom the leading sign of reticulate hyperpigmentation of the large flexures was lacking. Instead, Grover-like, erythematous, keratotic, excoriated papules and lentigo-like macules with predilection for the trunk were found. Histopathology of both, an excoriated papule and a lentigo-like macule revealed the diagnostic features of Galli-Galli disease namely, elongated, pigmented, finger-like rete ridges, intraepidermal lacunae and acantholysis. However, serial sections of the lentigo-like macule were needed to reveal some suprabasal and subcorneal lacunae with minimal acantholysis. Thus, a good clinicopathological correlation is essential to make the right diagnosis of Galli-Galli disease. Although Grover disease has been described in the setting of solid organ transplantation and immunosuppression, this is the first report of an atypical variant of Galli-Galli disease occurring in a liver transplant patient.

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Extensive Grover's-like eruption with lentiginous 'freckling': report of two cases

Cited by 20 publications

References 12 publications

Galli-Galli disease: A case report with review of the literature

Galli-Galli disease: A case report with review of the literature

Grover Disease: A Reappraisal of Histopathological Diagnostic Criteria in 120 Cases

Atypical Variant of Galli–Galli Disease (Grover-Like Eruption With Lentiginous Freckling) in a Liver Transplant Patient

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