Partial unilateral lentiginosis (PUL) is a pigmentation disorder characterized by multiple lentigines covering the normal skin with a unilateral, segmented pattern that stops at the midline. There has only been a few successful PUL treatments reported in the literature, and an ideal therapeutic method has not yet been identified. We report a case of facial PUL that was successfully treated with a 532-nm Q-switched neodymium-ser with subsequent low-fluence 1,064-nm QS Nd:YAG laser treatment. The patient did not experience recurrence until 3 years after the treatment. This appears to be a promising therapeutic approach for PUL. Additional research should be conducted for further assessment of this method.