Extra-Amniotic Prostaglandin E2 and the Unfavourable Cervix

A COMPARISON OF PGE2 AND PGF2α VAGINAL GEL FOR RIPENING THE CERVIX BEFORE INDUCTION OF LABOUR

“…VIRTUALLY all the published work on the use of prostaglandins for cervical ripening prior to induction of labour in the human has involved the administration of prostaglandin E, (Calder et al, 1977;Thiery et al, 1977;Shepherd et al, 1976;MacKenzie and Embrey,. 1977).…”

An evaluation of the Bishop scoring system in relation to a method of induction of labour by intra-vaginal prostaglandin

“…This early work refers to induction of labour by syntocinon and artificial rupture of the membranes. The use of local prostaglandins to ripen the cervix before induction was first proposed by Shepherd, Sims and Craft (1976) and Calder, Embrey and Tait (1977). Later McKenzie and Embrey (1977) showed that local prostaglandin affected the ripeness of the cervix, but it was not until Gordon-Wright and Elder (1979) described the use of prostaglandin tablets locally to induce labour that the substance was routinely used for induction rather than to ripen the cervix before induction by other agents.…”

Comparative trial of extra-amniotic and vaginal prostaglandin E2in tylose gel for induction of labor

“…There is also an increased workload on nursing staff. Local protaglandins (vaginal and extra-amniotic) have been used with success for pre-induction 'priming' when the cervix is unripe and have been found to produce less gastrointestinal side effects than other routes of administration [3,11,13]. This trial sets out to compare the effectiveness of single doses of PGE 2 in tylose gel given either extraamniotically or vaginally prior to the surgical induction of labor in patients of varying parity and cervical 'ripeness'.…”