Extra-gastrointestinal stromal tumor of the pancreas: report of a case

Abstract

Gastrointestinal tumors (GISTs) of the pancreas are extremely rare with limited individual case reports and small number of case series. Herein, we report a case of pancreatic extragastrointestinal stromal tumor (EGIST) along with literature review. A 64-year-old female patient was referred to us for treatment of an abdominal mass detected by ultrasonographic examination. The tumor was located in the periamullary region. Under a preoperative diagnosis of a duodenal GIST, we performed a pylorus preserving pancreatoduodenectomy for this lesion. Laboratory examination results were within normal ranges. On pathologic gross examination, the tumor measured at 7 cm in its greatest dimension almost entirely involved the pancreatic head. Its cut surface was rubbery and white. It was surrounded by a thin pseudocapsule and well demarcated. Histopathological examination of the specimen showed a cellular lesion with compressed pancreatic tissue at peripheral. Mitotic count was 5 per 50 high-power fields. Immunohistochemically, neoplastic cells were positive for antibodies against C-KIT (CD117), CD 34, and vimentin. However, smooth-muscle actin reactions with antibodies against S-100 or desmin were negative. Based on above findings, the tumor was finally diagnosed as GISTs originating from the pancreas. The patient has been followed up postoperatively for 72 months. There is no evidence of recurrence. Here we report this case of pancreatic EGIST presenting as a solid neoplasm along with literature review of cases previously described. Our review on pancreatic EGISTs is limited and insufficient to make a conclusion regarding its clinical features. Those manifested large masses tended to have an aggressive biological and clinical behavior. Thus, pancreatic EGISTs need to be carefully differentiated. Adequate surgical intervention is necessary for pancreatic EGISTs.

Application Effect Analysis of Operating Room Detailed Nursing Based on Medical Big Data in Patients Undergoing Gastrointestinal Tumor Surgery

“…Room. Compared with traditional nursing work, the meticulous care in the operating room allows patients to feel more considerate service, let them carefully immerse themselves in the warm treatment environment, follow the hospital's arrangements, improve patient satisfaction, treat patients, provide convenience for the operation, smooth implementation, improve the quality of postoperative rehabilitation of patients, and increase patient satisfaction with nursing work [14].…”

Rare Double Primary Malignancies: A Pancreatic Gastrointestinal Stromal Tumor Mimicking as a Metastatic Lesion of Myoepithelial Carcinoma of Parotid Gland

“…It is commonly used as a marker to assess microvessel density (MVD) in various tissues and tumors. In the context of PGIST, its expression is observed in more than 50% of cases [18]. It serves as one of the immunohistochemical markers used to aid in the diagnosis of GIST, often in conjunction with other markers like CD117 and DOG1.…”

Comments and illustrations of the European Federation of Societies for Ultrasound in Medicine guidelines: Rare pancreatic tumors, ultrasound and contrast-enhanced ultrasound features—Malignant mesenchymal tumors

“…Endosonographically, pancreatic EGISTs appear in the case reports as smoothly circumscribed hypoechoic lesions, occasionally with cystic portions. [ 99 , 111 , 126 ] Cases with EUS-FNB of pancreatic EGISTs have been described. [ 111 , 126 – 128 ] In a single case report of a pancreatic EGIST at the pancreatic body, CEH-EUS with SonoVue demonstrated hyperenhancement of the tumor in the arterial phase.…”