Extra-gastrointestinal stromal tumour. Report of primary tumour in the omentum

Valdés-Peregrina, Estefanie Nayeli; Hernández‐González, Miguel; León-Pacheco, O. de; Mendoza-Ramírez, Saulo

doi:10.1016/j.hgmx.2016.12.002

Cited by 4 publications

(6 citation statements)

References 15 publications

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“…Prognosis of EGIST including omental EGIST following resection is thought to be less favorable than that of GIST. 9 Tumor size may not be reliable prognostic parameter in omental GISTs 3 as shown by our patient. However, the average large tumor size and high mitotic count have a remarkable negative impact on the overall survival.…”

Section: Discussionmentioning

confidence: 62%

“… 8 The importance of primary EGIST in the omentum is emphasized as few cases are reported in literature. 3 , 9 We report the first case in our facility.…”

Section: Discussionmentioning

confidence: 85%

“… 2 The risk stratification of our patient was a large size of tumor greater than 10 cm(25 cm across the widest dimension at surgery) with mitosis described as brisk and being extra gastrointestinal even without rupture was high risk. 9 Up to 66% of patients with high risk GISTs who had resection experience recurrence. 5 The risk of recurrence has been associated with inadequate resection and may involve the loss of the c-Kit gene.…”

Section: Discussionmentioning

confidence: 99%

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Extra-gastrointestinal stromal tumour of the lesser omentum presenting as a massive intra-abdominal swelling: A case report and literature review

Ashindoitiang,

Nwagbara,

Ugbem

et al. 2024

Rare Tumors

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Extra gastrointestinal stromal tumour(EGIST) is rare and is regarded as gastrointestinal stromal tumour(GIST) that originates outside of the gastrointestinal tract. They originate from other intraabdominal tissues such as the omentum, mesentery and peritoneum. The cell of origin is the interstitial cell of Cajal(ICC), a pacemaker cell that controls gastrointestinal peristalsis and the tumor is characterized by the expression of KIT(CD117) a transmembrane tyrosine kinase receptor. Here, a 49-year-old female who presented with a 6 month history of abdominal pain, progressive abdominal swelling and the presence of an upper abdominal mass. She had surgical resection and adjuvant imatinib for the intraabdominal mass diagnosed on histology and immunohistochemistry as EGIST of the lesser omentum. Serial CT 14 months after surgery revealed no evidence of recurrence or metastasis. Clinicians should consider EGIST in the differential diagnosis of abdominal masses.

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Section: Discussionmentioning

confidence: 62%

“… 8 The importance of primary EGIST in the omentum is emphasized as few cases are reported in literature. 3 , 9 We report the first case in our facility.…”

Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

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Extra-gastrointestinal stromal tumour of the lesser omentum presenting as a massive intra-abdominal swelling: A case report and literature review

Ashindoitiang,

Nwagbara,

Ugbem

et al. 2024

Rare Tumors

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“…Expression of DOG-1 in membranous and cytoplasmic patterns usually highlights E-GISTs. 4,5,12,21 The 11-kDa glycosylated transmembrane protein CD34 is positively expressed in up to 70%, and SMA is in 30-40%. Desmin and S-100 are only expressed in 5% of cases.…”

Section: Discussionmentioning

confidence: 99%

“…4 Metastases in the liver are commonly present in advanced cases of GISTs, while it is rare to find metastases in lymph nodes. 4,21 Puckett et al reported a rectal GIST with diffuse liver metastases. 23 The case revealed multiple lesions in the liver.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic challenges of gastrointestinal stromal tumour during transurethral resection of the prostate: A case report

Putriyuni,

Zulfiqar,

Saberko

et al. 2023

JKKI

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Mesenchymal prostate tumours are relatively rare compared to epithelial tumours. To diagnose mesenchymal tumours on transurethral resection of the prostate (TURP) specimen, doctors have to consider a few differential diagnoses, including gastrointestinal stromal tumour (GISTs). We reported a 63 years-old male patient, presented with urinary retention in one week. Based on an initial scan of the abdomen, a large lobulated mass in the pelvic cavity from the prostate pushed up the urinary bladder. Histopathologic examination demonstrated cellular spindle cell neoplastic proliferation, a moderate degree of atypia, and a mitotic count of >5 per 50 high-power fields (HPFs) with a fascicular growth pattern. Immunohistochemically, the tumour had positive expression for CD117 (c-KIT), CD34, and discovered on Gist-1 (DOG-1), while smooth muscle actin (SMA) and S-100 were negative. The pathological report was consistent with a high-risk group of GISTs in the prostate. Subsequent imaging revealed that the tumour mass was centrally located between the rectum and prostate, infiltrating bladder and liver metastases. Comprehensive differential diagnoses of mesenchymal tumours involving the prostate are necessary because of the inadequacy of specific clinical signs, symptoms, and unexpected location. Diagnoses of GISTs was performed based on spindle cell pattern and the positive immunohistochemistry expression for CD117, CD34, and DOG-1. The tumour mass involved in the prostate with spindled morphology should be considered as a GIST, assisted with appropriate immunohistochemistry marker panel. It is a challenge to diagnose the GIST particularly involving the prostate.

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2018

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Extra-gastrointestinal stromal tumour. Report of primary tumour in the omentum

Cited by 4 publications

References 15 publications

Extra-gastrointestinal stromal tumour of the lesser omentum presenting as a massive intra-abdominal swelling: A case report and literature review

Extra-gastrointestinal stromal tumour of the lesser omentum presenting as a massive intra-abdominal swelling: A case report and literature review

Diagnostic challenges of gastrointestinal stromal tumour during transurethral resection of the prostate: A case report

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