Extra nodular metastasis is a poor prognostic factor for overall survival in node-positive patients with colorectal cancer

Ambe, Peter C.; Gödde, Daniel; Störkel, Stephan; Zirngibl, Hubert; Bönicke, Lars

doi:10.1007/s00384-018-2991-0

Cited by 6 publications

(5 citation statements)

References 28 publications

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“…As increased complexity was associated with worse prognosis, our results are in line with studies using histopathologic definitions in which the prognosis of both LNMs with ENE and TDs is worse than that of LNMs without ENE. 3,6,14 The finding that tumor nodules with a more complex shape are associated with worse DFS compared with those with a less complex shape is in contrast with a previous study in which it was found that the contour of TDs was not associated with prognosis. 15 However, there are several differences between both studies that should be emphasized.…”

Section: Discussioncontrasting

confidence: 82%

“…This has been identified as a poor prognostic factor compared with LNMs without ENE. 5,6 Additionally, TDs, referred to as isolated tumor aggregates in the fat surrounding the bowel, also have an independent prognostic impact in CRC. 3,4 Currently, ENE is not separately included in the staging of patients with CRC and TDs are categorized in the nodal stage as N1c, only having clinical impact in the absence of LNMs.…”

Section: Introductionmentioning

confidence: 99%

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The Complexity of Shapes: How the Circularity of Tumor Nodules Affects Prognosis in Colorectal Cancer

Brouwer,

Khan,

Bokhorst

et al. 2024

Modern Pathology

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Section: Discussioncontrasting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

The Complexity of Shapes: How the Circularity of Tumor Nodules Affects Prognosis in Colorectal Cancer

Brouwer,

Khan,

Bokhorst

et al. 2024

Modern Pathology

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“…It is known that metastasis is an independent predictor for poor prognosis of many cancer types (124–126). We find that elevated expression of SIRT1 was correlated with OS, DFS, EFS, and PFS.…”

Section: Discussionmentioning

confidence: 99%

Survival and Clinicopathological Significance of SIRT1 Expression in Cancers: A Meta-Analysis

Sun

Zhang

et al. 2019

Front. Endocrinol.

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Background: Silent information regulator 2 homolog 1 (SIRT1) is an evolutionarily conserved enzymes with nicotinamide adenine dinucleotide (NAD)+-dependent deacetylase activity. SIRT1 is involved in a large variety of cellular processes, such as genomic stability, energy metabolism, senescence, gene transcription, and oxidative stress. SIRT1 has long been recognized as both a tumor promoter and tumor suppressor. Its prognostic role in cancers remains controversial.Methods: A meta-analysis of 13,138 subjects in 63 articles from PubMed, EMBASE, and Cochrane Library was performed to evaluate survival and clinicopathological significance of SIRT1 expression in various cancers.Results: The pooled results of meta-analysis showed that elevated expression of SIRT1 implies a poor overall survival (OS) of cancer patients [Hazard Ratio (HR) = 1.566, 95% CI: 1.293–1.895, P < 0.0001], disease free survival (DFS) (HR = 1.631, 95% CI: 1.250–2.130, P = 0.0003), event free survival (EFS) (HR = 2.534, 95% CI: 1.602–4.009, P = 0.0001), and progress-free survival (PFS) (HR = 3.325 95% CI: 2.762–4.003, P < 0.0001). Elevated SIRT1 level was associated with tumor stage [Relative Risk (RR) = 1.299, 95% CI: 1.114–1.514, P = 0.0008], lymph node metastasis (RR = 1.172, 95% CI: 1.010–1.360, P = 0.0363), and distant metastasis (RR = 1.562, 95% CI: 1.022–2.387, P = 0.0392). Meta-regression and subgroup analysis revealed that ethnic background has influence on the role of SIRT1 expression in predicting survival and clinicopathological characteristics of cancers. Overexpression of SIRT1 predicted a worse OS and higher TNM stage and lymphatic metastasis in Asian population especially in China.Conclusion: Our data suggested that elevated expression of SIRT1 predicted a poor OS, DFS, EFS, PFS, but not for recurrence-free survival (RFS) and cancer-specific survival (CCS). SIRT1 overexpression was associated with higher tumor stage, lymph node metastasis, and distant metastasis. SIRT1-mediated molecular events and biological processes could be an underlying mechanism for metastasis and SIRT1 is a therapeutic target for inhibiting metastasis, leading to good prognosis.

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“…This is a retrospective analysis of prospectively collected data of patients undergoing oncologic resection of colorectal cancer. The data of all consecutive patients diagnosed with CRC is prospectively put into an institutional database by trained study nurses and research fellows as reported elsewhere [10, 11]. The database is continuously updated with data on the present status of all registered patients.…”

Section: Methodsmentioning

confidence: 99%

Routine preoperative mechanical bowel preparation with additive oral antibiotics is associated with a reduced risk of anastomotic leakage in patients undergoing elective oncologic resection for colorectal cancer

et al. 2019

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BackgroundAnastomotic leakage (AL) following colorectal resection is a serious issue. AL in oncologic patients might negatively affect the overall survival. Recently, mechanical bowel preparation with additive oral antibiotics (MBP + AB) prior to surgery has been suggested as a means of reducing AL. However, it is unclear whether this positive effect is secondary to MBP alone or secondary to the additive oral antibiotic (MBP + AB). The aim of this study was to investigate the effect of mechanical bowel preparation with additive oral antibiotics (MBP + AB) and without additive oral antibiotics (MBP − AB) on the rate of AL following colorectal resection for cancer.Materials and methodsPatients undergoing surgical management for colorectal cancer with anastomosis from January 2014 till September 2017 were included for analysis. Cases undergoing MBP + AB were included in the study group. Patients undergoing MBP − AB were included in the control group. Both groups were compared with regard to the rate of AL.ResultsFour hundred and ninety-six patients: 125 undergoing MBP + AB and 371 undergoing MBP – AB were included for analysis. Significantly, more male patients were included in the MBP – AB group compared to the MBP + AB group: 60.1% vs. 45.6% respectively (p = 0.03). Both groups were similar with regard to age distribution and clinicopathological findings (p > 0.05). The rate of AL was significantly higher in the control group (MBP − AB) compared to study group (MBP + AB) (9.1% vs. 4.0%, p = 0.03).ConclusionMechanical bowel preparation with additive oral antibiotics prior to elective colorectal resection with anastomosis significantly reduces the risk of AL. Therefore, mechanical bowel preparation with additive non-absorbable oral antibiotics should be recommended in all cases prior to elective colorectal surgery.

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Extra nodular metastasis is a poor prognostic factor for overall survival in node-positive patients with colorectal cancer

Abstract: Extra nodal metastasis is an independent prognostic factor in patients with node-positive colorectal cancer. Extra nodal metastasis is associated with high odds of tumor-related mortality and poor overall survival.

Cited by 6 publications

References 28 publications

The Complexity of Shapes: How the Circularity of Tumor Nodules Affects Prognosis in Colorectal Cancer

The Complexity of Shapes: How the Circularity of Tumor Nodules Affects Prognosis in Colorectal Cancer

Survival and Clinicopathological Significance of SIRT1 Expression in Cancers: A Meta-Analysis

Routine preoperative mechanical bowel preparation with additive oral antibiotics is associated with a reduced risk of anastomotic leakage in patients undergoing elective oncologic resection for colorectal cancer

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