Extra Pulmonary Manifestations of SARS-CoV-2 Infection in Pediatrics. Review

Ayala, Zoilo Morel; Buongermini, Ana; Cuéllar, Celia Martínez de; Jiménez, Mabel Zacur de; Pastore, Leticia Ramírez; Lezcano, María Concepción; Greco, J; Brítez, Ricardo Meza

doi:10.18004/anales/2020.053.02.87

Cited by 3 publications

(15 citation statements)

References 55 publications

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“…Ten reviews were evaluated, 1 systematic review [30] and 9 narrative reviews [6][7][8][9][26][27][28][29], with one being eliminated for low quality, (AMSTAR 1 score < 8) [25]; the rest were of high quality (AMSTAR 1 score ≥ 8). The methodological quality of each review was chosen according to the summary in Figure 2.…”

Section: Methodological Qualitymentioning

confidence: 99%

“…After the AMSTAR 1 criteria were applied by two researchers independently, 1 article [25] was excluded for only meeting 7 of the 11 criteria to be evaluated (7/11), which is a lowquality indicator. A total of nine articles [6][7][8][9][26][27][28][29][30] were included in this review of reviews, of which only one was a systematic review [30] and eight were narrative reviews of the literature.…”

Section: Review Selectionmentioning

confidence: 99%

“…In turn, new manifestations of the virus affecting the gastrointestinal, cardiovascular, dermatological, and nervous system appeared [4,5], generating disorders for those infected [4]. Heart disease is a disorder present in patients with COVID-19; monitoring of patients with cardiac arrhythmias is important in this infection [6].…”

Section: Introductionmentioning

confidence: 99%

“…Patients with COVID-19 (COVID-19+) may develop symptoms such as fever, cough, pharyngeal pain, abdominal pain, diarrhea, conjunctivitis, muscle fatigue, and pneumonia [1,6] and may be left with serious side effects or even die [7]. Symptomatology is diverse and depends on whether the patient is a child or an adult [6]; fever, cough, rhinorrhea, vomiting, diarrhea, and myalgias are more common in infants, while their respiratory systems are less severe [8]; children account for 1-5% of asymptomatic cases [2].…”

Section: Introductionmentioning

confidence: 99%

“…Based on severity, this disease can be divided into five clinical subtypes: asymptomatic infection, mild disease, characteristic clinical case, severe clinical case, and critically severe case [6]. There are numerous asymptomatic cases to date and we do not yet understand why, so it is considered relevant to identify the clinical manifestations of COVID-19, specifically skin manifestations, because they may be a typical indicator of COVID-19 infection in asymptomatic subjects [9].…”

Section: Introductionmentioning

confidence: 99%

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Clinical Manifestations of COVID-19 in the Feet: A Review of Reviews

Jiménez-Cebrián

Castro-Méndez

García-Podadera

et al. 2021

JCM

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There is a lack of scientific evidence about the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The clinical manifestations are not thoroughly understood; classically, the virus manifests itself at the pulmonary level but can manifest at other levels. To the best of our knowledge, systematic reviews and non-systematic reviews about COVID-19 symptoms in the feet have not been published. The aim of this review of reviews was to analyze and synthesize the published reviews on manifestations of COVID-19 at the foot level. Methods: a review of reviews was conducted; the eligibility criteria included studies published in English or Spanish, involving children and adults with COVID-19, and reporting foot manifestations. PubMed, SciELO, Science Direct, Cochrane Database of Systematic Review, and Google Scholar were analyzed. Two authors independently performed the screening and quality assessment of the studies with AMSTAR 1, and finally, nine reviews were analyzed (one systematic and eight narratives studies). The main clinical manifestations at the foot level in patients with COVID-19 were vascular (edema, exanthems, chilblains, ischemia, and distal necrosis), dermatological (vesicular, maculopapular, papulosquamous, urticarial skin breakouts, and recurrent herpes), and neurological (muscular weakness in lower limbs, paresis, areflexias, ataxia, and difficulty walking). Erythema pernio or “COVID toes” was shown as the most characteristic lesion of this disease, especially in asymptomatic children and young people, so this typical manifestation may be considered important in patients who are positive for COVID-19. This finding does not allow for strong conclusions due to the scarce literature and methodological quality in this regard. Future studies are necessary.

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Section: Methodological Qualitymentioning

confidence: 99%

Section: Review Selectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical Manifestations of COVID-19 in the Feet: A Review of Reviews

Jiménez-Cebrián

Castro-Méndez

García-Podadera

et al. 2021

JCM

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Rabdomiólisis e infección a SARS-CoV-2 en paciente joven

Escobar-Salinas,

Peralta-Giménez

2023

Rev. Inst. Med. Trop.

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La rabdomiólisis es un síndrome clínico causado por la lesión de miocitos y liberación de su contenido celular al espacio extracelular y a la circulación sanguínea. Se manifiesta por dolor muscular agudo y debilidad, malestar general, fiebre y orina oscura. El diagnostico se realiza por las manifestaciones clínicas y el dosaje de las sustancias citosólicas liberadas. Se presenta el caso de un varón joven que desarrolla un cuadro agudo de mialgias generalizadas y debilidad muscular de miembros inferiores coincidentemente con la infección a SARS-CoV-2.

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