Extra-Small Gold Nanospheres Decorated With a Thiol Functionalized Biodegradable and Biocompatible Linear Polyamidoamine as Nanovectors of Anticancer Molecules

Bloise, Nora; Massironi, Alessio; Pina, Cristina Della; Alongi, Jenny; Siciliani, Stella; Manfredi, Amedea; Biggiogera, Marco; Rossi, M.; Ferruti, Paolo; Ranucci, Elisabetta; Visai, Livia

doi:10.3389/fbioe.2020.00132

Cited by 23 publications

(28 citation statements)

References 116 publications

(148 reference statements)

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Section: P E R S O N a L A C C O U N T T H E C H E M I C A L R E C O R Dmentioning

confidence: 99%

“…Moreover, the selection of mercapto functional groups can avoid the formation of AuÀ S bonds to ensure no cytotoxicity. [62] Sanfilippo et al fabricated a novel multifunctional nanoplatform at room temperature using spherical gold nanoparticles (AuNPs) as a core-shell structure and capped with hyaluronic acid (HA). HA effectively "surface modified" gold nanoparticles make the grafting density of biomacromolecule chains on the surface of metal nanoparticles is different, thus affecting the physical and chemical properties of nanoparticles.…”

Section: P E R S O N a L A C C O U N T T H E C H E M I C A L R E C O R Dmentioning

confidence: 99%

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Functionalized Gold Nanoparticles: Synthesis, Properties and Biomedical Applications

Fan

Cheng

Sun

2020

The Chemical Record

127

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Gold nanoparticles have excellent optical and plasmon properties and have enormous research potential when they combine with different ligands. Functionalized gold nanoparticles are widely used in drug delivery, biological detection, sensors, and even clinical treatment. At present, with the rapid development of functionalized gold nanoparticles, we think it is necessary to sort out the recent research results. In this paper, the synthesis, characteristics, and biological applications of the three aspects are introduced. Firstly, the synthetic methods of functionalized gold nanoparticles are reviewed, and the improvement of the commonly used synthetic methods is summarized. Then, the catalytic properties, oxidation resistance, and chirality optical properties are summarized in detail. Finally, we summarize the research progress in the field of biology in recent years.

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Section: P E R S O N a L A C C O U N T T H E C H E M I C A L R E C O R Dmentioning

confidence: 99%

Section: P E R S O N a L A C C O U N T T H E C H E M I C A L R E C O R Dmentioning

confidence: 99%

Functionalized Gold Nanoparticles: Synthesis, Properties and Biomedical Applications

Fan

Cheng

Sun

2020

The Chemical Record

127

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“…[ 184,185 ] Similar results were found by studying the antipsychotic drug chlorpromazine. [ 186–188 ] Nonetheless, these results have not been validated in in vivo models. More recent trial demonstrated that the antiemetic and antipsychotic drug prochlorperazine (PCZ) can be repurposed to reversibly inhibit dynamin‐mediated endocytosis of membrane proteins targeted by therapeutic mAbs.…”

Section: Cell Surface Conjugation Routesmentioning

confidence: 98%

“…[183] Therefore, means to prolong cell surface retention of NPs have been studied. [171,172,[184][185][186][187][188][189] In a thiol-maleimide approach, NPs-binding proteins have been identified by mass spectrometry. [171] The leukocyte common antigen CD45 is predominantly bound by maleimide-functionalized NPs.…”

Section: Cell Surface Retentionmentioning

confidence: 99%

“…Consequently, other ways to increase cell surface retention have been investigated. [184][185][186][187][188][189] Depending on their compositions and the type of interaction with the cell, NPs can be internalized by different mechanisms (e.g., clathrinand/or caveolae-mediated endocytosis). [190] Converging in vitro and in vivo evidences demonstrated that the antimalarial agent chloroquine effectively inhibits NPs clathrin-mediated endocytosis by depleting the phosphatidylinositol binding clathrin assembly protein.…”

Section: Cell Surface Retentionmentioning

confidence: 99%

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Leveraging Immunotherapy with Nanomedicine

Mittelheisser

Banerjee

Pivot

et al. 2020

Advanced Therapeutics

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Considerable progress has been made in the development and understanding of immunotherapy, notably with the emergence of novel chimeric antigen receptor T cells (CAR-T) which changed the perception of personalized therapy. However, cell-based immunotherapy not only lacks therapeutic efficiency in various solid cancers but also raises concerns related to important side effects. The convergence of immunotherapy and nanomedicine is timely as nanoparticles can now be easily conjugated to various antibodies and peptides enabling outstanding abilities to target specific cell populations in vivo. Here, the state of the art of immunonanotherapy that activates the immune system in vivo, by acting either as vaccines or as tumor microenvironment (TME) activators is described. Then, the development of ex vivo immune-cell surface labeling strategies is discussed to exploit immune cells as trojan horses and thereby improving the delivery of the therapeutics in the TME. Such a strategy is likely to considerably amplify the efficacy of immunotherapy.

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