Extração de ácido trans-trans mucônico urinário com polímeros de impressão molecular e análise por cromatografia gasosa: espectrometria de massas

Franqui, Lidiane S.; Vieira, André Coutinho; Maia, Paulo Henrique M.; Figueiredo, Eduardo Costa

doi:10.1590/s0100-40422012000800016

Cited by 4 publications

(2 citation statements)

References 19 publications

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“…[62] . Vieira et al desenvolveram MIPs para a extração de ácido trans, transmucônico (AttM), um metabólito do benzeno, a partir de amostras de urina, seguido por análise com HPLC-UV [63] e cromatografia gasosa-espectrometria de massas (GC-MS) [64] . A 4-vinilpiridina foi utilizada para a síntese por ser um monômero de característi-cas básicas.…”

Section: Metodologias De Sínteseunclassified

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Emprego de polímeros de impressão molecular em preparo de amostras para análise de compostos orgânicos: aplicações e tendências

Santos¹,

Abrão²,

Freitas³

et al. 2012

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ResumoOs polímeros de impressão molecular são materiais sintéticos dotados de sítios específicos de reconhecimento. Esses materiais são obtidos por reações de polimerização que fixam, estrategicamente, monômeros funcionais ao redor de uma molécula modelo de acordo com os grupos ligantes e com a estereoquímica de ambas as moléculas. Os MIPs têm sido amplamente empregados em procedimentos de preparo de amostras, como extração e microextração em fase sólida, extração sortiva em barra de agitação, extração com adsorvente magnético, microextração com sorvente empacotado, entre outras. Este artigo de revisão tem como objetivo apresentar o que há de mais recente no emprego de MIP para extração de compostos orgânicos, evidenciando as vantagens de cada aplicação, bem como as mais promissoras tendências que sustentam a evolução e o aperfeiçoamento de cada técnica. Palavras-chavePolímeros de impressão molecular; MIP; preparo de amostras.Molecularly imprinted polymers in sample preparation for organic compounds analysis: applications and trends AbstractMolecularly imprinted polymers are synthetic materials with molecular recognition ability. These materials are obtained by polymerization reactions that fix the functional monomers around the template molecule according with the binding groups and the stereochemistry of both molecules. The MIPs have been extensively used in several applications with emphasis for sample preparation procedures as solid phase extraction, solid phase microextraction, extraction by magnetic sorbents, microextraction by packed sorbent among others. So, the objective of this review is to present the novelty in MIP use for organic compounds extraction and point out the advantages of each application, as well as what is most promising in the evolution and improvement of each technique.

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Section: Metodologias De Sínteseunclassified

“…Vale ressaltar que foi possível reaproveitar o mesmo cartucho de MIP por cerca de 100 ciclos. Ambos os métodos mostraram eficiência equivalente ao procedimento baseado em extração por troca iônica e podem ser alternativas interessantes para análise de AttM em laboratórios de rotina [63,64] .…”

Section: Metodologias De Sínteseunclassified

Emprego de polímeros de impressão molecular em preparo de amostras para análise de compostos orgânicos: aplicações e tendências

Santos¹,

Abrão²,

Freitas³

et al. 2012

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A new restricted access molecularly imprinted polymer capped with albumin for direct extraction of drugs from biological matrices: the case of chlorpromazine in human plasma

et al. 2013

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A new restricted access molecularly imprinted polymer coated with bovine serum albumin (RAMIP-BSA) was developed, characterized, and used for direct analysis of chlorpromazine in human plasma samples. The RAMIP-BSA was synthesized using chlorpromazine, methacrylic acid, and ethylene glycol dimethacrylate as template, functional monomer, and cross-linker, respectively. Glycerol dimethacrylate and hydroxy methyl methacrylate were used to promote a hydrophilic surface (high density of hydroxyl groups). Afterward, the polymer was coated with BSA using glutaraldehyde as cross-linker, resulting in a protein chemical shield around it. The material was able to eliminate ca. 99% of protein when a 44-mg mL(-1) BSA aqueous solution was passed through it. The RAMIP-BSA was packed in a column and used for direct analysis of chlorpromazine in human plasma samples in an online column switching high-performance liquid chromatography system. The analytical calibration curve was prepared in a pool of human plasma samples with chlorpromazine concentrations ranging from 30 to 350 μg L(-1). The correlation coefficient obtained was 0.995 and the limit of quantification was 30 μg L(-1). Intra-day and inter-day precision and accuracy presented variation coefficients and relative errors lower than 15% and within -15 and 15%, respectively. The sample throughput was 3 h(-1) (sample preparation and chromatographic analysis steps) and the same RAMIP-BSA column was efficiently used for about 90 cycles.

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Pre-concentration of rosuvastatin using solid-phase extraction in a molecularly imprinted polymer and analytical application in water supply

Silva

Feiteira

Francisco

et al. 2020

Environ Sci Pollut Res

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In this work, it is shown the development and validation of innovative analytical methodology based on solid-phase extraction (SPE) with molecularly imprinted polymers (MIP) as a sorbent associated to UV-Vis spectroscopy to isolate and quantify, respectively, rosuvastatin (RSV) in water samples. For this purpose, porogenic solvent in MIP synthesis and SPE extraction parameters for MIP and non-imprinted polymers (NIP) were evaluated univariately for comparison purposes. The sorptive capacity and characterization studies by infrared spectroscopy and atomic force microscopy showed difference between MIP and NIP. The selectivity study of the MIP-RSVagainst other statins (simvastatin and atorvastatin) showed that the synthesized MIP can also be applied as a solid phase for isolation and quantitative pre-concentration of RSVand atorvastatin. The conjugation of SPE and UV-Vis spectroscopy in the determination of RSV in aqueous matrices led to large factor of pre-concentration (125 times), limit of detection (LOD) of 3 μg L−1, limit of quantification (LOQ) of 10 μg L−1, precision of 2.87% (n = 10), and accuracy of 83.1% (n = 4).

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Extração de ácido trans-trans mucônico urinário com polímeros de impressão molecular e análise por cromatografia gasosa: espectrometria de massas

Cited by 4 publications

References 19 publications

Emprego de polímeros de impressão molecular em preparo de amostras para análise de compostos orgânicos: aplicações e tendências

Emprego de polímeros de impressão molecular em preparo de amostras para análise de compostos orgânicos: aplicações e tendências

A new restricted access molecularly imprinted polymer capped with albumin for direct extraction of drugs from biological matrices: the case of chlorpromazine in human plasma

Pre-concentration of rosuvastatin using solid-phase extraction in a molecularly imprinted polymer and analytical application in water supply

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