Extracellular and immunological actions of zinc

Impact of Hemodialysis on Serum Zinc and Copper Level in CKD Patients

“…The mechanism of elevated zinc after hemodialysis not yet understood, our suggestion could be related to increase transporter protein after hemodialysis, it is well known that zinc transported bound with prealbumin, albumin and transferrin, thus could protected against filtration during hemodialysis, this providing interesting observation that, beside elevated zinc levels after hemodialysis CKD patients have decrease zinc level. In fact that zinc deficiency in developing countries due to socioeconomic and malnutrition factors associated with delayed wound healing (Shrimpton et al, 2005;Prasad, 1988), and immune deficiency which might contribute to the excess risk of infection observed in hemodialysis patients (Collins et al 2005;Ishani et al, 2005;Rink and Gabriel, 2000).…”

“…Therefore the present study hypothized HD has an influence on trace elements and minerals thus patients with CKD at risk to develop a metabolic disorders due to deficiency and/or increase of these elements. CKD patients are at higher risk for zinc deficiency, with up to 78 % of hemodialysis patients being deficient (Roozbeh et al, 2011), . which is required for numerous important biological activities in the body such as oxidative metabolism (Bozalioglu et al, 2005), and it is one of the main participants of immunological activities (Rink and Gabriel, 2001). Copper proteins have diverse roles in biological electron transport and oxygen transportation thus deficiency can cause anemia and neutropenia (Bonham et al, 2002).…”

Zinc supplementation attenuates ethanol- and acetaldehyde-induced liver stellate cell activation by inhibiting reactive oxygen species (ROS) production and by influencing intracellular signaling

“…In addition to its essential role in various immunological functions [36], zinc has a dual effect on the secretion of pro-inflammatory cytokines. It has been reported to trigger the release of these cytokines by monocytes [37], but suppression of cytokine production has also been found [38,39].…”

Zinc status and age-related changes in peripheral blood leukocyte subpopulations in healthy men and women aged 55–70 y: the ZENITH study

“…It is estimated that 49 and 58% of 51-70 y olds and 70 þ y olds, respectively, are zinc inadequate (Briefel et al, 2000). The effects of zinc deficiency on immune function have been reasonably well documented, with substantial effects reported on CMI (Shankar & Prasad, 1998;Fraker et al, 2000;Rink & Gabriel, 2000;Rink & Gabriel, 2001;Ibs & Rink, 2003). Zinc deficiency also results in depressed innate immunity (Keen & Gershwin, 1990;Prasad, 2000;Dardenne, 2002).…”