2007
DOI: 10.1042/bst0350219
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Extracellular and subcellular regulation of the PI3K/Akt cassette: new mechanisms for controlling insulin and growth factor signalling

Abstract: The PI3K (phosphoinositide 3-kinase)/Akt (also called protein kinase B) signalling cassette plays a central role in the response to growth factors, particularly insulin-like molecules, and its misregulation is a characteristic feature of diabetes and many forms of human cancer. Recent molecular genetic studies initiated in the fruitfly, Drosophila melanogaster, have highlighted two new cell-type-specific mechanisms regulating PI3K/Akt signalling and its downstream effects. First, the cellular response to this … Show more

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Cited by 10 publications
(6 citation statements)
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“…The PI3K/Akt signaling pathway plays a central role in the response to various growth factors and is well characterized in a variety of disorders such as cancer and diabetes [12,13]. Mammalian target of the rapamycin (mTOR) protein kinase is known to be a major component of the PI3K/Akt singling pathway which is a key regulator of cell proliferation, apoptosis, and glucose metabolism [14,15].…”
Section: Introductionmentioning
confidence: 99%
“…The PI3K/Akt signaling pathway plays a central role in the response to various growth factors and is well characterized in a variety of disorders such as cancer and diabetes [12,13]. Mammalian target of the rapamycin (mTOR) protein kinase is known to be a major component of the PI3K/Akt singling pathway which is a key regulator of cell proliferation, apoptosis, and glucose metabolism [14,15].…”
Section: Introductionmentioning
confidence: 99%
“…Understandably, once activated, Akt needs to be recruited to different intracellular compartments to phosphorylate its substrates. In this regard, regulation of Akt cellular compartmentalization constitutes a critical mechanism to regulate Akt signaling (41).…”
mentioning
confidence: 99%
“…The remarkably diverse and cell type specific functions of Akt1 in the context of InR/TOR signaling have recently been attributed to the existence of different subcellular pools of activated Akt1 kinase that control different cellular processes [ 44 ]. For example, whereas activated Akt1 is predominantly found at the apical membrane of Drosophila eye tissue, it is mostly cytoplasmic in the Drosophila ovary, where it regulates the lipid metabolism in nurse and follicle cells [ 18 ], [ 44 ], [ 45 ]. This specific ovarian function of Akt1 is under the control of Wdb, selectively modulating the levels of cytoplasmic phosphorylated Akt1 and thereby lipid droplet size in ovarian cells [ 18 ].…”
Section: Resultsmentioning
confidence: 99%