Extracellular ATP Shapes a Defense-Related Transcriptome Both Independently and along with Other Defense Signaling Pathways

Jewell, Jeremy B.; Sowders, Joel M.; He, Rong; Willis, Mark A.; Gang, David R.; Tanaka, Kiwamu

doi:10.1104/pp.18.01301

Cited by 79 publications

(95 citation statements)

References 87 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this manner, extracellular ATP can be considered as a signalling molecule for the activation of Arabidopsis defence responses (Cao et al , ). More recently, extracellular ATP has been shown to play a role in the JA‐induced defence response of Arabidopsis through the direct activation of JA signalling (but not via JA biosynthesis) (Tripathi et al , ; Jewell et al , ). Evidence for a role of extracellular ATP as signalling molecule for the expression of defence responses in rice is, however, lacking.…”

Section: Discussionmentioning

confidence: 99%

Phosphate excess increases susceptibility to pathogen infection in rice

Campos-Soriano

Bundó

Bach‐Pages

et al. 2020

Molecular Plant Pathology

View full text Add to dashboard Cite

Phosphorus (P) is an essential nutrient for plant growth and productivity. Due to soil fixation, however, phosphorus availability in soil is rarely sufficient to sustain high crop yields. The overuse of fertilizers to circumvent the limited bioavailability of phosphate (Pi) has led to a scenario of excessive soil P in agricultural soils. Whereas adaptive responses to Pi deficiency have been deeply studied, less is known about how plants adapt to Pi excess and how Pi excess might affect disease resistance. We show that high Pi fertilization, and subsequent Pi accumulation, enhances susceptibility to infection by the fungal pathogen Magnaporthe oryzae in rice. This fungus is the causal agent of the blast disease, one of the most damaging diseases of cultivated rice worldwide. Equally, MIR399f overexpression causes an increase in Pi content in rice leaves, which results in enhanced susceptibility to M. oryzae. During pathogen infection, a weaker activation of defence‐related genes occurs in rice plants over‐accumulating Pi in leaves, which is in agreement with the phenotype of blast susceptibility observed in these plants. These data support that Pi, when in excess, compromises defence mechanisms in rice while demonstrating that miR399 functions as a negative regulator of rice immunity. The two signalling pathways, Pi signalling and defence signalling, must operate in a coordinated manner in controlling disease resistance. This information provides a basis to understand the molecular mechanisms involved in immunity in rice plants under high Pi fertilization, an aspect that should be considered in management of the rice blast disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Phosphate excess increases susceptibility to pathogen infection in rice

Campos-Soriano

Bundó

Bach‐Pages

et al. 2020

Molecular Plant Pathology

View full text Add to dashboard Cite

show abstract

“…Complex mechanisms underlying protease-mediated peptide signal activation merit vigorous studies under different stress conditions. Extracellular ATP recognition by the lectin RK P2K1/DORN1 in Arabidopsis involves MYC2/MYC3/MYC4 and CAMTA3 during PTI (Choi et al, 2014;Jewell et al, 2019). DORN1 phosphorylates RBOHD in guard cells to close stomata during bacterial resistance and water-deficit tolerance Fig.…”

Section: Reviewmentioning

confidence: 99%

Plant immunity in signal integration between biotic and abiotic stress responses

2019

View full text Add to dashboard Cite

Summary Plants constantly monitor and cope with the fluctuating environment while hosting a diversity of plant‐inhabiting microbes. The mode and outcome of plant–microbe interactions, including plant disease epidemics, are dynamically and profoundly influenced by abiotic factors, such as light, temperature, water and nutrients. Plants also utilize associations with beneficial microbes during adaptation to adverse conditions. Elucidation of the molecular bases for the plant–microbe–environment interactions is therefore of fundamental importance in the plant sciences. Following advances into individual stress signaling pathways, recent studies are beginning to reveal molecular intersections between biotic and abiotic stress responses and regulatory principles in combined stress responses. We outline mechanisms underlying environmental modulation of plant immunity and emerging roles for immune regulators in abiotic stress tolerance. Furthermore, we discuss how plants coordinate conflicting demands when exposed to combinations of different stresses, with attention to a possible determinant that links initial stress response to broad‐spectrum stress tolerance or prioritization of specific stress tolerance.

show abstract

“…Simultaneous genetic blockage of nucleoside uptake and hydrolysis leads to an accumulation of adenosine and uridine in the apoplast, a reduction of PSII efficiency, and a higher susceptibility to the necrotrophic fungus Botrytis cinerea, possibly caused by reduced expression of WRKY33 (Daumann et al, 2015), which is known to be essential for Botrytis resistance (Liu et al, 2015). Treatment with eATP increases the resistance to Botrytis (Tripathi et al, 2018), and the expression of WRKY33 and other defense-related genes is reduced in a DORN1 mutant and boosted in a DORN1 overexpression line upon challenge with eATP (Jewell et al, 2019). Taken together, these observations suggest that adenosine accumulation in the apoplast dampens the DORN1-mediated response, indicating that ENT3 and NSH3 are required to remove the breakdown products of eATP signaling.…”

Section: Pyrimidine Nucleotide Degradationmentioning

confidence: 99%