Extracellular defence against oxidative stress in the newborn

Berger, Howard; Molicki, Jacek; Moison, Ralf M.W.; Zoeren‐Grobben, Diny van

doi:10.1016/s1084-2756(98)80003-1

Cited by 12 publications

(11 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The passage across the placenta may decrease with increasing gestational age because the level in cord blood is higher in preterm than in term infants. Immediately after birth, ascorbic acid concentrations fall in the blood [35] . A relation between high ascorbic plasma concentration at birth and poor outcome in preterm infants has been shown [36] .…”

Section: Ascorbic Acid and Tocopherolmentioning

confidence: 99%

Oxidative Stress in the Newborn – A 30-Year Perspective

2005

View full text Add to dashboard Cite

In this review the development of the concept ‘hypoxia-reoxygenation injury’ is outlined. An update of some important factors and mechanisms related to oxidative stress injury in newborn infants is presented, including the metabolism of glutathione, the role of antioxidants, iron and nitric oxide, and how these may influence health and disease in the newborn and contribute to ‘oxygen radical disease of the newborn’. New insight into how hyperoxia and hypoxia may induce changes leading to retinopathy of prematurity by vascular endothelial growth factor acting in concert with insulin-like growth factor is briefly summarized. Inflammation and oxidative stress seem to be two sides of the same coin in newborn babies both contributing to injury partly through similar mechanisms.

show abstract

Section: Ascorbic Acid and Tocopherolmentioning

confidence: 99%

Oxidative Stress in the Newborn – A 30-Year Perspective

2005

View full text Add to dashboard Cite

show abstract

“…Most of the studies focused on the impact of low antioxidant defenses on the incidence of BPD. Neonates are short in antioxidant defenses, on both their extracellular (41,42) and intracellular part (42,43). Moreover, in preterm animals, in contrast with term, induction of antioxidative enzymes does not occur after oxidative stress (41,44).…”

Section: Discussionmentioning

confidence: 99%

“…Neonates are short in antioxidant defenses, on both their extracellular (41,42) and intracellular part (42,43). Moreover, in preterm animals, in contrast with term, induction of antioxidative enzymes does not occur after oxidative stress (41,44). Randomized trials of antioxidant intervention in premature infants, with strong rationale and good study design, failed to demonstrate any improvement on BPD incidence (36,(45)(46)(47).…”

Section: Discussionmentioning

confidence: 99%

Early Inhaled Nitric Oxide Improves Oxidative Balance in Very Preterm Infants

Hamon

Fresson²,

Nicolas

et al. 2005

Pediatr Res

View full text Add to dashboard Cite

Inhaled nitric oxide (iNO) improves oxygenation in premature infants, but concern has been raised about its potential oxidative toxicity. We designed this study to assess the oxidative balance in premature infants who were exposed to low dose iNO and the relationship with their clinical outcome on day 28 of life. A total of 274 infants who were Ͻ32 wk gestation were randomized at birth to receive 5 ppm of iNO if they presented with hypoxemic respiratory failure. Nonhypoxemic infants were studied as the reference group. Blood samples were withdrawn 24 h apart, within the first 4 d of life, to assess malondialdehyde (MDA) concentration as oxidative stress marker and total plasmatic glutathione (GSH), intraerythrocyte GSH peroxidase, and GSH reductase activities as antioxidant defenses. After 24 h, the rise in MDA was blunted in the iNO group compared with controls and was close to the reference infants. Conversely, GSH was more stable in the iNO group, when there was no difference for the GSH peroxidase and GSH reductase activities. On day 28, Oxygen dependence was linked with a higher increase in MDA as was the risk for death, whereas intraventricular hemorrhage was associated with a higher initial drop in GSH. Early low-dose iNO in hypoxemic preterm infants improves oxidative balance and seems to be clinically beneficial up to day 28 of life. Since 1992, several randomized trials have shown that inhaled nitric oxide (iNO) significantly improved oxygenation in term or near-term infants, with a significant reduction in the use of extracorporeal membrane oxygenation (1-6). In 1997, Skimming et al. (7) were the first to report a positive response of 23 premature infants with respiratory distress syndrome to low-dose iNO (5 ppm). Since then, a few clinical trials involving a small number of premature infants have shown that the initial improvement in oxygenation seemed to be transient (8 -10) because no improvement in mortality or in morbidity had been demonstrated (11). However, most of these studies were considering iNO therapy in premature infants who had severe hypoxemic respiratory failure or refractory hypoxemia (8,10,11) or were at an advanced stage of respiratory insufficiency (12). Most of them used a high dosage of iNO (10 -20 ppm).Finally, concerns have been raised about specific side effects of this new molecule that could worsen long-term outcome after an initial improvement in this high-risk population (13)(14)(15). Besides the risk for increased brain hemorrhage as a result of a prolonged bleeding time (16), neonatologists remain cautious in the use of this treatment because NO behaves as a "chameleon" molecule for the oxidative balance. Endogenous NO is incriminated in the cascade leading to cerebral lesions in perinatal experimental models of hypoxo-ischemic injuries (17). In addition, iNO may interact with oxygen to form nitrogen dioxide and peroxynitrites, which would enhance pulmonary toxicity. This is a main concern when dealing with Received May 20, 2004; accepted September 27, 2004

show abstract

“…In contrast to the high total ascorbic acid concentrations (both ascorbic acid and its oxidized form, dehydroascorbic acid) in preterm cord blood, although they fall rapid after delivery [39,40], Scott et al [57] and Moison et al [58] have shown that concentrations of caeruloplasmin (hence the ferroxidase it contains) were lower in cord blood than in plasma from adults, and premature newborns also have lower plasma transferrin concentration. The significance of the interaction between transferrin, caeruloplasmin, ascorbic acid and iron in the pathogenesis of diseases such as respiratory distress syndrome and hypoxic/ischaemic encephalopathy in the newborn has already been extensively reviewed by Berger [59]. Briefly, high concentrations of ascorbic acid inhibit caeruloplasmin activity, favouring the existence of oxidative Fe 2' ion that acts as a catalyst for peroxidation.…”

Section: Antioxidant Defence In Extreme Prematuritymentioning

confidence: 99%

Influence of early postnatal nutritional management on oxidative stress and antioxidant defence in extreme prematurity

Yeung¹

2006

Acta Paediatrica

View full text Add to dashboard Cite

The increased survival of infants born at mid-gestation in the last decade is associated with significant oxygen free radical-mediated morbidities. Resuscitation with 100% oxygen, oxidant load from parenteral nutrition fluids, and oxidant stress inherent to the systemic inflammatory state subsequent to infection and tissue injury are all contributory.Conclusion: Improving early postnatal protein nutrition and the formulation of parenteral nutrition fluids would potentially reduce the oxidative stress and enhance the antioxidant defence of extremely premature newborns.

show abstract

Extracellular defence against oxidative stress in the newborn

Cited by 12 publications

References 49 publications

Oxidative Stress in the Newborn – A 30-Year Perspective

Oxidative Stress in the Newborn – A 30-Year Perspective

Early Inhaled Nitric Oxide Improves Oxidative Balance in Very Preterm Infants

Influence of early postnatal nutritional management on oxidative stress and antioxidant defence in extreme prematurity

Contact Info

Product

Resources

About