Extracellular extracts of antagonistic fungi,Trichoderma longibrachiatum and Trichoderma viride, as larvicides against dengue vectors, Aedes aegypti and Aedes albopictus

Perera, Dinusha S.; Tharaka, W.G. Hiruni; Amarasinghe, L.D.; Wickramarachchi, Suranga R.

doi:10.1016/j.actatropica.2022.106747

Cited by 8 publications

(5 citation statements)

References 13 publications

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“…Similarly as the procedure of Divi and co-workers, [12] we synthesized 3 from ethyl nicotinate 1 and N-vinylpyrrolidone 2, and then myosmine (4) was obtained via the general method. Instead of using palladium catalysts, we chose cheaper and safer NaBH 4 to obtain nornicotine (5), which greatly improved safety and yield. Then nicotine (6) could be obtained from 5, and a series of nornicotine-typed compounds were easy to yield as general procedure (Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…Plant essential oils were found to show the essential effect as environmentally friendly larvicides in the control of Aedes species, [4] and the same as extracts from plants or microorganisms. [5] Among these natural extracts, tobacco extracts have larvicidal activity against pests, such as Aedes species because of nicotine and other derivatives. [6] Nicotine and other nornicotine-typed compounds are important alkaloids found in Solanaceae plants.…”

Section: Introductionmentioning

confidence: 99%

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Nornicotine‐Typed Insecticides: The Potential Insecticides with Strong Activity Against Aedes Albopictus

Cao,

Deng,

Zhang

et al. 2024

ChemistrySelect

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Aedes albopictus, the main vector of dengue, yellow fever, chikungunya, and Zika, has caused significant public health concerns, but there are still few effective insecticides. Nicotine and nornicotine‐typed compounds are well‐known for their potential as an insecticide, which has potential activity against Ae. albopictus. Here we report the effects of nornicotine‐typed insecticide against larvae of Ae. albopictus. We developed a novel synthetic strategy for nicotine and nornicotine‐typed compounds. Novel compounds A1‐A8 and B1‐B26 were synthesized by the synthesized nornicotine. And bioassays indicated that most of these compounds exhibited good effects against larvae of Ae. albopictus, and compounds A3, B4, B20, and B26 had excellent activity against Ae. albopictus, and they were not toxic to humans according to other reports. After considering the cost, compounds B4, B20, and B26 could be potential lead compounds against Ae. albopictus and other Aedes mosquitoes.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nornicotine‐Typed Insecticides: The Potential Insecticides with Strong Activity Against Aedes Albopictus

Cao,

Deng,

Zhang

et al. 2024

ChemistrySelect

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“…P-orlandin, a nontoxic metabolite from A. niger, can target mosquito FREP1, which is a critical protein for parasite infection in Anopheles gambiae and could block malaria transmission [83]. Several fungal cell culture filtrates have displayed mortality against mosquito [84]. Recent research on fungal metabolites in mosquito control is summarized in Supplementary Table S1.…”

Section: Combined With Microbial Metabolites or Microbial Organismsmentioning

confidence: 99%

“…Recent research of fungal metabolites 35 in mosquito control. References [46,48,49,70,71,79,[82][83][84][124][125][126][127][128][129] are cited in the supplementary materials.…”

Section: Supplementary Materialsmentioning

confidence: 99%

Recent Advancements in Pathogenic Mechanisms, Applications and Strategies for Entomopathogenic Fungi in Mosquito Biocontrol

Qin

Liu

Peng

et al. 2023

JoF

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Fungal diseases are widespread among insects and play a crucial role in naturally regulating insect populations. Mosquitoes, known as vectors for numerous infectious diseases, pose a significant threat to human health. Entomopathogenic fungi (EPF) have emerged as highly promising alternative agents to chemical mosquitocides for controlling mosquitoes at all stages of their life cycle due to their unique infection pathway through direct contact with the insect’s cuticle. In recent years, significant advancements have been made in understanding the infection pathways and pathogenic mechanisms of EPF against mosquitoes. Various strategies involving the use of EPF alone or combinations with other approaches have been employed to target mosquitoes at various developmental stages. Moreover, the application of genetic technologies in fungi has opened up new avenues for enhancing the mosquitocidal efficacy of EPF. This review presents a comprehensive summary of recent advancements in our understanding the pathogenic mechanisms of EPF, their applications in mosquito management, and the combination of EPF with other approaches and employment of transgenic technologies. The biosafety concerns associated with their use and the corresponding approaches are also discussed. The recent progress suggests that EPF have the potential to serve as a future biorational tool for controlling mosquito vectors.

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“…Moreover, T . viride has also been used as an effective larvicide against dengue mosquitoes (Perera et al 2023 ) and root-knot nematodes (Patil et al 2021 ). In addition to its biocontrol potential in plants, T .…”

Section: Introductionmentioning

confidence: 99%

Enhanced resistance to heat and fungal infection in transgenic Trichoderma via over-expressing the HSP70 gene

Huang,

Liu,

Huo

et al. 2024

AMB Expr

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Heat stress is one of the major abiotic stresses affecting the growth, sporulation, colonization and survival of Trichoderma viride. This study aimed to gain a better insight into the underlying mechanism governing the heat stress response of T. viride Tv-1511. We analysed the transcriptomic changes of Tv-1511 under normal and heat stress conditions using RNA sequencing. We observed that Tv-1511 regulates the biosynthesis of secondary metabolites through a complex network of signalling pathways. Additionally, it significantly activates the anti-oxidant defence system, heat shock proteins and stress-response-related transcription factors in response to heat stress. TvHSP70 was identified as a key gene, and transgenic Tv-1511 overexpressing TvHSP70 (TvHSP70-OE) was generated. We conducted an integrated morphological, physiological and molecular analyses of the TvHSP70-OE and wild-type strains. We observed that TvHSP70 over-expression significantly triggered the growth, anti-oxidant capacity, anti-fungal activity and growth-promoting ability of Tv-1511. Regarding anti-oxidant capacity, TvHSP70 primarily up-regulated genes involved in enzymatic and non-enzymatic anti-oxidant systems. In terms of anti-fungal activity, TvHSP70 primarily activated genes involved in the synthesis of enediyne, anti-fungal and aminoglycoside antibiotics. This study provides a comparative analysis of the functional significance and molecular mechanisms of HSP70 in Trichoderma. These findings provide a valuable foundation for further analyses.

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Extracellular extracts of antagonistic fungi,Trichoderma longibrachiatum and Trichoderma viride, as larvicides against dengue vectors, Aedes aegypti and Aedes albopictus

Cited by 8 publications

References 13 publications

Nornicotine‐Typed Insecticides: The Potential Insecticides with Strong Activity Against Aedes Albopictus

Nornicotine‐Typed Insecticides: The Potential Insecticides with Strong Activity Against Aedes Albopictus

Recent Advancements in Pathogenic Mechanisms, Applications and Strategies for Entomopathogenic Fungi in Mosquito Biocontrol

Enhanced resistance to heat and fungal infection in transgenic Trichoderma via over-expressing the HSP70 gene

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