Extracellular Hyaline Material in Association with Other Cytologic Features in Aspirates from Collagenous Spherulosis and Adenoid Cystic Carcinoma of the Breast

Jain, Shyama; Gupta, Sanjay; Kumar, Neeta; Sodhani, Pushpa

doi:10.1159/000326537

Cited by 14 publications

(10 citation statements)

References 11 publications

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“…Adenoid cystic carcinoma-like growth pattern with characteristic hyaline globules have been reported in tumors other than adenoid cystic carcinoma of salivary gland, including breast, upper respiratory tract, esophagus, prostate, uterine cervix, synovial sarcoma, and collagenous spherulosis of the breast [4][5][6][7][8][9]. This pattern can be rarely seen in papillary and follicular carcinomas of the thyroid [10][11][12][13][14].…”

Section: Discussionmentioning

confidence: 99%

Unique Growth Pattern in Papillary Carcinoma of the Thyroid Gland Mimicking Adenoid Cystic Carcinoma

2011

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We report here three cases of papillary thyroid carcinoma (PTC) with hyaline globules as seen in adenoid cystic carcinoma of the salivary glands. This unique growth pattern was seen in two cases of columnar cell and one case of cribriform morular variant of PTC. Fine-needle aspiration was performed in two cases. By immunohistochemistry, all cases demonstrated expression of TTF-1 and thyroglobulin confirming follicular cell derivation. It is important to be aware of this unusual growth pattern in thyroid carcinomas; immunohistochemistry is warranted for rendering accurate cytopathologic and histopathologic diagnosis.

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Section: Discussionmentioning

confidence: 99%

Unique Growth Pattern in Papillary Carcinoma of the Thyroid Gland Mimicking Adenoid Cystic Carcinoma

2011

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“…However, 1 study pointed out the essential difficulty of the differential diagnosis of CS from ACC based on the cytologic characteristics. 20 Furthermore, 2 cases of ACC arising in AME have been reported. 21 Therefore, it is important to rule out ACC, and the recognition of AME as underlying pathology of CS cannot become sufficient evidence for differentiating CS from ACC.…”

Section: Discussionmentioning

confidence: 99%

Collagenous Spherulosis Associated with Adenomyoepithelioma of the Breast

Ohta¹,

Mori²,

Kawada³

et al. 2010

Acta Cytologica

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“…Cytologic features from FNA specimens are useful to suggest the presence of CS. [9][10][11][12][13][14] The spherules are round and stain pink with Diff-Quick and light green with PAP stain. The former stain may highlight their fibrillary appearance.…”

Section: Discussionmentioning

confidence: 99%

“…The recognition of isolated naked spherules (as were recorded in two of six cases from aspirates from CS and adenoid cystic carcinoma of the breast) is interesting. 14 Cytologically, the classical differential diagnosis in MS includes adenoid cystic carcinoma. In addition, our case showed small amounts of mucoid material (MS) that might induce to rule-out mucinous lesions such as mucocele-like tumor, mucinous carcinoma, mixed infiltrating ductal carcinoma with mucinous differentiation, intraductal signet-ring cell carcinoma, and myxoid fibroadenomas.…”

Section: Discussionmentioning

confidence: 99%

A case of mucinous spherulosis of the breast diagnosed retrospectively in FNA material

Laforga

2006

Diagnostic Cytopathology

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We describe for the first time the cytologic features of mucinous spherulosis (MS), a variant of collagenous spherulosis (CS) of the breast characterized by cribiform structures containing lightly basophilic material, embedded in a loosely mucinous acellular background. Histologically, the lesion was part of a complex hyperplasia containing foci of sclerosing adenosis, and foci of atypical ductal hyperplasia (ADH). Immunohistochemical study showed reactivity with smooth muscle actin and focally for cytokeratin 14. Cytologic features of MS were recognized retrospectively and consisted of intermediate to large round hyaline spherules, naked or surrounded by myoepithelial cells. A fibrillary radial appearance was observed with Diff-Quick stain. We draw attention to the importance of recognizing these features because they can easily pose problems either by being overlooked or overdiagnosed as mucinous carcinoma. Differential diagnosis is briefly discussed.

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Extracellular Hyaline Material in Association with Other Cytologic Features in Aspirates from Collagenous Spherulosis and Adenoid Cystic Carcinoma of the Breast

Cited by 14 publications

References 11 publications

Unique Growth Pattern in Papillary Carcinoma of the Thyroid Gland Mimicking Adenoid Cystic Carcinoma

Unique Growth Pattern in Papillary Carcinoma of the Thyroid Gland Mimicking Adenoid Cystic Carcinoma

Collagenous Spherulosis Associated with Adenomyoepithelioma of the Breast

A case of mucinous spherulosis of the breast diagnosed retrospectively in FNA material

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