2015
DOI: 10.1371/journal.pone.0140910
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Extracellular Matrix and Growth Factors Improve the Efficacy of Intramuscular Islet Transplantation

Abstract: BackgroundThe efficacy of intramuscular islet transplantation is poor despite being technically simple, safe, and associated with reduced rates of severe complications. We evaluated the efficacy of combined treatment with extracellular matrix (ECM) and growth factors in intramuscular islet transplantation.MethodsMale BALB/C mice were used for the in vitro and transplantation studies. The following three groups were evaluated: islets without treatment (islets-only group), islets embedded in ECM with growth fact… Show more

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Cited by 29 publications
(23 citation statements)
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“…Moreover, this tissue shows a high oxygen tension, which is ideal for islet engraftment. Some studies support the hypothesis that this site is one of the most suitable sites for islet transplantation (Stokes et al, ), but results regarding its efficacy are heterogeneous, highlighting the need to use additional strategies to improve islet engraftment and to reduce the fibrotic process (Fransson et al, ; Tsuchiya et al, ; Yoshimatsu et al, ). The bone medullary cavity is a well vascularized and easily accessible space occupied by the bone marrow that offers sufficient space for multiple infusions with minimal trauma and spares the islets from IBMIR (Salazar‐Bañuelos, Wright, Sigalet, & Benítez‐Bribiesca, ). Islets survive and engraft successfully after intrabone marrow islet transplantation in both animal models (Cantarelli et al, ; Kover et al, ; K. C. Yang, Wu, et al, ) and humans (Maffi et al, ).…”
Section: The Liver As a Suboptimal Receptor Site For Islet Transplantmentioning
confidence: 99%
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“…Moreover, this tissue shows a high oxygen tension, which is ideal for islet engraftment. Some studies support the hypothesis that this site is one of the most suitable sites for islet transplantation (Stokes et al, ), but results regarding its efficacy are heterogeneous, highlighting the need to use additional strategies to improve islet engraftment and to reduce the fibrotic process (Fransson et al, ; Tsuchiya et al, ; Yoshimatsu et al, ). The bone medullary cavity is a well vascularized and easily accessible space occupied by the bone marrow that offers sufficient space for multiple infusions with minimal trauma and spares the islets from IBMIR (Salazar‐Bañuelos, Wright, Sigalet, & Benítez‐Bribiesca, ). Islets survive and engraft successfully after intrabone marrow islet transplantation in both animal models (Cantarelli et al, ; Kover et al, ; K. C. Yang, Wu, et al, ) and humans (Maffi et al, ).…”
Section: The Liver As a Suboptimal Receptor Site For Islet Transplantmentioning
confidence: 99%
“…Cellulose is also another polysaccharide that has been occasionally used in islet transplantation with successful results (Risbud, Bhargava, & Bhonde, ). Considering the influence of ECM on islet survival and function (Llacua et al, ; Tsuchiya et al, ; R. N. Wang & Rosenberg, ), the use of ECM‐derived proteins as a scaffold in these approaches is an obvious adaptation. Similarly, polypeptides, ECM‐derived proteins, or polymerizable proteins such as fibrin or silk have been used as scaffolds in islet transplantation.…”
Section: Tissue Engineering In Islet Transplantationmentioning
confidence: 99%
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