“…Moreover, this tissue shows a high oxygen tension, which is ideal for islet engraftment. Some studies support the hypothesis that this site is one of the most suitable sites for islet transplantation (Stokes et al, ), but results regarding its efficacy are heterogeneous, highlighting the need to use additional strategies to improve islet engraftment and to reduce the fibrotic process (Fransson et al, ; Tsuchiya et al, ; Yoshimatsu et al, ). - The bone medullary cavity is a well vascularized and easily accessible space occupied by the bone marrow that offers sufficient space for multiple infusions with minimal trauma and spares the islets from IBMIR (Salazar‐Bañuelos, Wright, Sigalet, & Benítez‐Bribiesca, ). Islets survive and engraft successfully after intrabone marrow islet transplantation in both animal models (Cantarelli et al, ; Kover et al, ; K. C. Yang, Wu, et al, ) and humans (Maffi et al, ).
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