2020
DOI: 10.3390/cancers12113455
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Extracellular MicroRNAs as Intercellular Mediators and Noninvasive Biomarkers of Cancer

Abstract: MicroRNAs (miRNAs) are released by different types of cells through highly regulated mechanisms under normal and pathological conditions. These extracellular miRNAs can be delivered into recipient cells for functional purposes, acting as cell-to-cell signaling mediators. It has been discovered that cancer cells release miRNAs into their surroundings, targeting normal cells or other cancer cells, presumably to promote tumor development and progression. These extracellular miRNAs are associated with oncogenic me… Show more

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Cited by 35 publications
(29 citation statements)
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References 235 publications
(293 reference statements)
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“…The clinical outcome of NSCLC remains unsatisfactory due to the high metastasis and recurrence rates ( 4 ). It is well-known that miRNAs play important roles in the progression and development of several diseases, including cancers ( 21 23 ). For example, miR4766-5p, miR-1915-3p and miR-615-3p are associated with tumor development in gastric cancer ( 24 26 ).…”
Section: Discussionmentioning
confidence: 99%
“…The clinical outcome of NSCLC remains unsatisfactory due to the high metastasis and recurrence rates ( 4 ). It is well-known that miRNAs play important roles in the progression and development of several diseases, including cancers ( 21 23 ). For example, miR4766-5p, miR-1915-3p and miR-615-3p are associated with tumor development in gastric cancer ( 24 26 ).…”
Section: Discussionmentioning
confidence: 99%
“…In 2007, miRNAs were reported to be released by cells into the extracellular space, and these cell-free miRNAs are transferable and functional in recipient cells [ 38 , 39 ]. Cell-free miRNAs can be released and uptaken by cells through vesicle trafficking and protein carrier mechanisms, and they are able to function as gene expression regulators in cell-to-cell communication mechanisms under normal and pathological conditions, such as cancer [ 10 , 14 , 38 , 39 , 40 ].…”
Section: Mirnasmentioning
confidence: 99%
“…Since these initial studies, levels of circulating miRNAs in the plasma and serum of healthy individuals were found to be constant [ 8 , 59 ], whereas the levels in cancer patients (including lung cancer) are altered. These altered miRNAs could be used to distinguish cancer patients from healthy individuals, prompting the search for miRNAs that may be used as non-invasive biomarkers for diagnosis and prognosis [ 8 , 9 , 10 , 14 ].…”
Section: Mirnasmentioning
confidence: 99%
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