Extracellular vesicle-derived miRNA as a novel regulatory system for bi-directional communication in gut-brain-microbiota axis

Zhao, Liang; Ye, Yingze; Gu, Lijuan; Jian, Zhihong; Stary, Creed M.; Xiong, Xiaoxing

doi:10.1186/s12967-021-02861-y

Cited by 35 publications

(18 citation statements)

References 192 publications

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“…PAMP, consisting of outer membrane porin, flagellin, and peptidoglycan, is another carrier that can stimulate immunity (Bauman and Kuehn 2006 ; Renelli et al 2004 ). Microbial-derived OMVs transfer a wide range of materials, including bioactive proteins, lipids, nucleic acids, and virulence factors, to neighboring bacteria or host cells (epithelial cells, endothelial cells, immune cells) (Zhao et al 2021 ). This biological information transmission plays a vital role in both intracellular (bacterial-bacterial) interactions and inter-kingdom (bacterial-host) communication.…”

Section: Main Textmentioning

confidence: 99%

Functional Two-Way Crosstalk Between Brain and Lung: The Brain–Lung Axis

Chen

et al. 2022

Cell Mol Neurobiol

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The brain has many connections with various organs. Recent advances have demonstrated the existence of a bidirectional central nervous system (CNS) and intestinal tract, that is, the brain-gut axis. Although studies have suggested that the brain and lung can communicate with each other through many pathways, whether there is a brain–lung axis remains still unknown. Based on previous findings, we put forward a hypothesis: there is a cross-talk between the central nervous system and the lung via neuroanatomical pathway, endocrine pathway, immune pathway, metabolites and microorganism pathway, gas pathway, that is, the brain–lung axis. Beyond the regulation of the physiological state in the body, bi-directional communication between the lung and the brain is associated with a variety of disease states, including lung diseases and CNS diseases. Exploring the brain–lung axis not only helps us to understand the development of the disease from different aspects, but also provides an important target for treatment strategies.

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Section: Main Textmentioning

confidence: 99%

Functional Two-Way Crosstalk Between Brain and Lung: The Brain–Lung Axis

Chen

et al. 2022

Cell Mol Neurobiol

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“…To date, there is evidence showing that a microbial product of Bacteroides fragilis lipopolysaccharide can act as a neurotoxin via induction of a series of miRNAs targeting genes that regulate synaptic plasticity, amyloidogenesis, and inflammatory signaling in the brain ( Zhao et al, 2021 ). Also, other metabolites produced by the intestinal microbiota, such as tryptophan, butyrate, acetylcholine, norepinephrine, serotonin, dopamine can influence miRNA activity.…”

Section: The Role Of Microrna On Depression Anxiety and Microbiota Co...mentioning

confidence: 99%

The Role of MicroRNA and Microbiota in Depression and Anxiety

Rosa

Formolo

et al. 2022

Front. Behav. Neurosci.

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Depression and anxiety are devastating disorders. Understanding the mechanisms that underlie the development of depression and anxiety can provide new hints on novel treatments and preventive strategies. Here, we summarize the latest findings reporting the novel roles of gut microbiota and microRNAs (miRNAs) in the pathophysiology of depression and anxiety. The crosstalk between gut microbiota and the brain has been reported to contribute to these pathologies. It is currently known that some miRNAs can regulate bacterial growth and gene transcription while also modulate the gut microbiota composition, suggesting the importance of miRNAs in gut and brain health. Treatment and prevention strategies for neuropsychiatric diseases, such as physical exercise, diet, and probiotics, can modulate the gut microbiota composition and miRNAs expressions. Nonetheless, there are critical questions to be addressed to understand further the mechanisms involved in the interaction between the gut microbiota and miRNAs in the brain. This review summarizes the recent findings of the potential roles of microbiota and miRNA on the neuropathology of depression and anxiety, and its potential as treatment strategies.

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“…EVs represent an increasingly recognized and very important way of communication among different tissues in the organism. In this regard, this strategy is extremely efficient and is able to coordinate different organs including gut–brain [ 84 , 85 ], and pancreas–brain [ 86 ]. As was mentioned earlier, this communication is bidirectional, generating a higher level of complexity, playing an important role in both normal physiology as well as in disease [ 84 ].…”

Section: Gut Microbiota Shapes Pancreatic Beta-cellsmentioning

confidence: 99%

Multi-Organ Crosstalk with Endocrine Pancreas: A Focus on How Gut Microbiota Shapes Pancreatic Beta-Cells

Fernández-Millán

Guillén

2022

Biomolecules

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Type 2 diabetes (T2D) results from impaired beta-cell function and insufficient beta-cell mass compensation in the setting of insulin resistance. Current therapeutic strategies focus their efforts on promoting the maintenance of functional beta-cell mass to ensure appropriate glycemic control. Thus, understanding how beta-cells communicate with metabolic and non-metabolic tissues provides a novel area for investigation and implicates the importance of inter-organ communication in the pathology of metabolic diseases such as T2D. In this review, we provide an overview of secreted factors from diverse organs and tissues that have been shown to impact beta-cell biology. Specifically, we discuss experimental and clinical evidence in support for a role of gut to beta-cell crosstalk, paying particular attention to bacteria-derived factors including short-chain fatty acids, lipopolysaccharide, and factors contained within extracellular vesicles that influence the function and/or the survival of beta cells under normal or diabetogenic conditions.

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Extracellular vesicle-derived miRNA as a novel regulatory system for bi-directional communication in gut-brain-microbiota axis

Cited by 35 publications

References 192 publications

Functional Two-Way Crosstalk Between Brain and Lung: The Brain–Lung Axis

Functional Two-Way Crosstalk Between Brain and Lung: The Brain–Lung Axis

The Role of MicroRNA and Microbiota in Depression and Anxiety

Multi-Organ Crosstalk with Endocrine Pancreas: A Focus on How Gut Microbiota Shapes Pancreatic Beta-Cells

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