Extracellular vesicle-mediated crosstalk between pancreatic cancer and stromal cells in the tumor microenvironment

Liu, Ying; Zhao, Wei; Wang, Yanli; Wang, Haiyan; Liu, Shanglong

doi:10.1186/s12951-022-01382-0

Cited by 31 publications

(24 citation statements)

References 157 publications

(162 reference statements)

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“…The role of SEVs in intercellular communication, particularly during tumor development, has been extensively studied. SEVs deliver biologically active molecules such as proteins, mRNA, and miRNA to cells in the TME and thus, play an immunomodulatory role [67][68][69]. The role of SEVs in tumor immunity is double-edged, with both immunostimulatory and immunosuppressive effects; it acts mainly through regulating relevant immune cells in TME.…”

Section: The Roles Of Texs In Tmementioning

confidence: 99%

Tumor-derived small extracellular vesicles: potential roles and mechanism in glioma

2022

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Small extracellular vesicles (SEVs) are extracellular vesicles containing DNA, RNA, and proteins and are involved in intercellular communication and function, playing an essential role in the growth and metastasis of tumors. SEVs are present in various body fluids and can be isolated and extracted from blood, urine, and cerebrospinal fluid. Under both physiological and pathological conditions, SEVs can be released by some cells, such as immune, stem, and tumor cells, in a cytosolic manner. SEVs secreted by tumor cells are called tumor-derived exosomes (TEXs) because of their origin in the corresponding parent cells. Glioma is the most common intracranial tumor, accounting for approximately half of the primary intracranial tumors, and is characterized by insidious onset, high morbidity, and high mortality rate. Complete removal of tumor tissues by surgery is difficult. Chemotherapy can improve the survival quality of patients to a certain extent; however, gliomas are prone to chemoresistance, which seriously affects the prognosis of patients. In recent years, TEXs have played a vital role in the occurrence, development, associated immune response, chemotherapy resistance, radiation therapy resistance, and metastasis of glioma. This article reviews the role of TEXs in glioma progression, drug resistance, and clinical diagnosis.

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Section: The Roles Of Texs In Tmementioning

confidence: 99%

Tumor-derived small extracellular vesicles: potential roles and mechanism in glioma

2022

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“…First, extracellular vesicle-mediated signal transduction between pancreatic cancer cells and immune cells should be intensively studied. Extracellular vesicle can help facilitate an exchange of information within various cells in the TME ( 127 ). It has been found that extracellular vesicle-RNA and proteins are involved in the metastasis and chemotherapeutic resistance of pancreatic cancer ( 128 ).…”

Section: Areas Of Future Developmentmentioning

confidence: 99%

Neutrophils in pancreatic cancer: Potential therapeutic targets

Jiang

Xiang

et al. 2022

Front. Oncol.

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Pancreatic cancer is a digestive system malignancy and poses a high mortality worldwide. Traditionally, neutrophils have been thought to play a role in acute inflammation. In contrast, their importance during tumor diseases has been less well studied. Generally, neutrophils are recruited into the tumor microenvironment and exert inflammation and tumor-promoting effects. As an essential part of the tumor microenvironment, neutrophils play diverse roles in pancreatic cancer, such as angiogenesis, progression, metastasis and immunosuppression. Additionally, neutrophils can be a new potential therapeutic target in cancer. Inhibitors of cytokines, chemokines and neutrophil extracellular traps can exert antitumor effects. In this review, we describe the role of neutrophils in the development and progression of pancreatic cancer, discuss their potential as therapeutic targets, and aim to provide ideas for improving the prognosis of patients with this malignant tumor disease.

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“…Moreover, this ability was also found in circ-TFF1, which could induce epithelial-mesenchymal transition and therefore promote breast cancer tumor cells metastasis through the ceRNA mechanism ( 25 ). Exosomes were also drivers for tumor cells metastatic spread, circ_MMP2 was found to be driven by high metastatic tumor cells-secreted exosomes into normal hepatocellular cells and promoted tumorigenesis and metastasis in hepatocellular cancer via sponging miR-136-5p to enhance parental gene MMP2 (matrix metalloproteinases 2) expression ( 26 , 64 ). More notably, matrix metalloproteinases were important driving force for extracellular matrix and tissue destruction during tumor invasion and metastasis ( 65 ).…”

Section: The Role and Molecular Mechanisms Of Circrnas Regulating Par...mentioning

confidence: 99%

Circular RNAs regulate parental gene expression: A new direction for molecular oncology research

Wang

Gao

et al. 2022

Front. Oncol.

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CircRNAs have been the focus of research in recent years. They are differentially expressed in various human tumors and can regulate oncogenes and tumor suppressor genes expression through various mechanisms. The diversity, stability, evolutionary conservatism and cell- or tissue-specific expression patterns of circRNAs also endow them with important regulatory roles in promoting or inhibiting tumor cells malignant biological behaviors progression. More interestingly, emerging studies also found that circRNAs can regulate not only other genes expression, but also their parental gene expression and thus influence tumors development. Apart from some conventional features, circRNAs have a certain specificity in the regulation of parental gene expression, with a higher proportion affecting parental gene transcription and easier translation into protein to regulate parental gene expression. CircRNAs are generally thought to be unable to produce proteins and therefore the protein-coding ability exhibited by circRNAs in regulating parental gene expression is unique and indicates that the regulatory effects of parental gene expression by circRNAs are not only a competitive binding relationship, but also a more complex molecular relationship between circRNAs and parental gene, which deserves further study. This review summarizes the molecular mechanisms of circRNAs regulating parental gene expression and their biological roles in tumorigenesis and development, aiming to provide new ideas for the clinical application of circRNAs in tumor-targeted therapy.

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Extracellular vesicle-mediated crosstalk between pancreatic cancer and stromal cells in the tumor microenvironment

Cited by 31 publications

References 157 publications

Tumor-derived small extracellular vesicles: potential roles and mechanism in glioma

Tumor-derived small extracellular vesicles: potential roles and mechanism in glioma

Neutrophils in pancreatic cancer: Potential therapeutic targets

Circular RNAs regulate parental gene expression: A new direction for molecular oncology research

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