Extracellular vesicles: A potential future strategy for dental and maxillofacial tissue repair and regeneration

Liu, Ziwei; Wang, Situo; Huo, Na; Yang, Shuo; Shi, Quan; Xu, Juan

doi:10.3389/fphys.2022.1012241

Cited by 3 publications

(1 citation statement)

References 107 publications

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“…The application of MSCs-EVs in dentistry is restricted to fundamental research, and its clinical use requires more rigorous evidence. There is still a long way to go before MSCs-EVs can be used as an effective and safe dental clinical treatment method ( 220 ).…”

Section: Mscs-derived Evs and Therapy Of Periodontitismentioning

confidence: 99%

The role of extracellular vesicles in periodontitis: pathogenesis, diagnosis, and therapy

et al. 2023

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Periodontitis is a prevalent disease and one of the leading causes of tooth loss. Biofilms are initiating factor of periodontitis, which can destroy periodontal tissue by producing virulence factors. The overactivated host immune response is the primary cause of periodontitis. The clinical examination of periodontal tissues and the patient’s medical history are the mainstays of periodontitis diagnosis. However, there is a lack of molecular biomarkers that can be used to identify and predict periodontitis activity precisely. Non-surgical and surgical treatments are currently available for periodontitis, although both have drawbacks. In clinical practice, achieving the ideal therapeutic effect remains a challenge. Studies have revealed that bacteria produce extracellular vesicles (EVs) to export virulence proteins to host cells. Meanwhile, periodontal tissue cells and immune cells produce EVs that have pro- or anti-inflammatory effects. Accordingly, EVs play a critical role in the pathogenesis of periodontitis. Recent studies have also presented that the content and composition of EVs in saliva and gingival crevicular fluid (GCF) can serve as possible periodontitis diagnostic indicators. In addition, studies have indicated that stem cell EVs may encourage periodontal regeneration. In this article, we mainly review the role of EVs in the pathogenesis of periodontitis and discuss their diagnostic and therapeutic potential.

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Section: Mscs-derived Evs and Therapy Of Periodontitismentioning

confidence: 99%

The role of extracellular vesicles in periodontitis: pathogenesis, diagnosis, and therapy

et al. 2023

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Mesenchymal Stem Cell-based Scaffolds in Regenerative Medicine of Dental Diseases

Kiarashi,

Bayat,

Shahrtash

et al. 2024

Stem Cell Rev and Rep

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Extracellular vesicles as therapeutic tools in regenerative dentistry

Xia,

Zou,

Zhao

et al. 2024

Stem Cell Res Ther

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Dental and maxillofacial diseases are always accompanied by complicated hard and soft tissue defects, involving bone, teeth, blood vessels and nerves, which are difficult to repair and severely affect the life quality of patients. Recently, extracellular vesicles (EVs) secreted by all types of cells and extracted from body fluids have gained more attention as potential solutions for tissue regeneration due to their special physiological characteristics and intrinsic signaling molecules. Compared to stem cells, EVs present lower immunogenicity and tumorigenicity, cause fewer ethical problems, and have higher stability. Thus, EV therapy may have a broad clinical application in regenerative dentistry. Herein, we reviewed the currently available literature regarding the functional roles of EVs in oral and maxillofacial tissue regeneration, including in maxilla and mandible bone, periodontal tissues, temporomandibular joint cartilage, dental hard tissues, peripheral nerves and soft tissues. We also summarized the underlying mechanisms of actions of EVs and their delivery strategies for dental tissue regeneration. This review would provide helpful guidelines and valuable insights into the emerging potential of EVs in future research and clinical applications in regenerative dentistry.

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Extracellular vesicles: A potential future strategy for dental and maxillofacial tissue repair and regeneration

Cited by 3 publications

References 107 publications

The role of extracellular vesicles in periodontitis: pathogenesis, diagnosis, and therapy

The role of extracellular vesicles in periodontitis: pathogenesis, diagnosis, and therapy

Mesenchymal Stem Cell-based Scaffolds in Regenerative Medicine of Dental Diseases

Extracellular vesicles as therapeutic tools in regenerative dentistry

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